Show simple item record

dc.contributor.authorSkalko-Basnet, Natasa
dc.date.accessioned2022-05-05T09:05:01Z
dc.date.available2022-05-05T09:05:01Z
dc.date.issued2014-03-19
dc.description.abstractThe beginning of the 21st century saw numerous protein and peptide therapeuticals both on the market and entering the final stages of clinical studies. They represent a new category of biologically originated drugs termed biologics or biologicals. Their main advantages over conventional drugs can be summarized by their high selectivity and potent therapeutic efficacy coupled with limited side effects. In addition, they exhibit more predictable behavior under in vivo conditions. However, up to now most of the formulations of biologics are designed and destined for the parenteral route of administration. As a consequence, many suffer from short plasma half-lives, resulting in their frequent administration and ultimately poor patient compliance. This review represents an attempt to address some of the challenges and promises in the product development of biologics both for parenteral and noninvasive administration. Some of the products currently in the pipeline of pharmaceutical development and corresponding perspectives are discussed in more detail.en_US
dc.identifier.citationSkalko-Basnet N. Biologics: the role of delivery systems in improved therapy. Biologics: Targets and Therapy. 2014;8:107-114en_US
dc.identifier.cristinIDFRIDAID 1123457
dc.identifier.doihttps://doi.org/10.2147/BTT.S38387
dc.identifier.issn1177-5475
dc.identifier.issn1177-5491
dc.identifier.urihttps://hdl.handle.net/10037/25017
dc.language.isoengen_US
dc.publisherDovepressen_US
dc.relation.journalBiologics: Targets and Therapy
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2014 The Author(s)en_US
dc.titleBiologics: the role of delivery systems in improved therapyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record