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dc.contributor.authorIvanova, Lada
dc.contributor.authorRangel-Huerta, Oscar Daniel
dc.contributor.authorTartor, Haitham
dc.contributor.authorGjessing, Mona Cecilie
dc.contributor.authorDahle, Maria
dc.contributor.authorUhlig, Silvio
dc.date.accessioned2022-05-11T06:58:54Z
dc.date.available2022-05-11T06:58:54Z
dc.date.issued2021-12-31
dc.description.abstractMucous membranes such as the gill and skin mucosa in fish protect them against a multitude of environmental factors. At the same time, changes in the molecular composition of mucus may provide valuable information about the interaction of the fish with their environment, as well as their health and welfare. In this study, the metabolite profiles of the plasma, skin and gill mucus of freshwater Atlantic salmon (Salmo salar) were compared using liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS). Several normalization procedures aimed to reduce unwanted variation in the untargeted data were tested. In addition, the basal metabolism of skin and gills, and the impact of the anesthetic benzocaine for euthanisation were studied. For targeted metabolomics, the commercial AbsoluteIDQ p400 HR kit was used to evaluate the potential differences in metabolic composition in epidermal mucus as compared to the plasma. The targeted metabolomics data showed a high level of correlation between different types of biological fluids from the same individual, indicating that mucus metabolite composition could be used for fish health monitoring and research.en_US
dc.identifier.citationIvanova L, Rangel-Huerta OD, Tartor HM, Gjessing MCG, Dahle MK, Uhlig S. Fish Skin and Gill Mucus: A Source of Metabolites for Non-Invasive Health Monitoring and Research . Metabolites. 2022;12(1)en_US
dc.identifier.cristinIDFRIDAID 1974630
dc.identifier.doi10.3390/metabo12010028
dc.identifier.issn2218-1989
dc.identifier.urihttps://hdl.handle.net/10037/25063
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalMetabolites
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.titleFish Skin and Gill Mucus: A Source of Metabolites for Non-Invasive Health Monitoring and Researchen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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