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dc.contributor.authorKyrø, Cecilie
dc.contributor.authorOlsen, Anja
dc.contributor.authorLandberg, Rikard
dc.contributor.authorSkeie, Guri
dc.contributor.authorLoft, Steffen
dc.contributor.authorÅman, Per
dc.contributor.authorLeenders, Max
dc.contributor.authorDik, Vincent K.
dc.contributor.authorSiersema, Peter D.
dc.contributor.authorPischon, Tobias
dc.contributor.authorChristensen, Jane
dc.contributor.authorOvervad, Kim
dc.contributor.authorBoutron-Ruault, Marie Christine
dc.contributor.authorFagherazzi, Guy
dc.contributor.authorCottet, Vanessa
dc.contributor.authorKühn, Tilman
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorBoeing, Heiner
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorBamia, Christina
dc.contributor.authorTrichopoulos, Dimitrios
dc.contributor.authorPalli, Domenico
dc.contributor.authorKrogh, Vittorio
dc.contributor.authorTumino, Rosario
dc.contributor.authorVineis, Paolo
dc.contributor.authorPanico, Salvatore
dc.contributor.authorPeeters, Petra H.
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorBakken, Toril
dc.contributor.authorÅsli, Lene Angell
dc.contributor.authorArguelles, Marcial
dc.contributor.authorJakszyn, Paula
dc.contributor.authorSánchez, Maria-Jose
dc.contributor.authorAmiano, Pilar
dc.contributor.authorHuerta, Jose Maria
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorLjuslinder, Ingrid
dc.contributor.authorPalmqvist, Richard
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorWareham, Nick
dc.contributor.authorKey, Timothy J
dc.contributor.authorTravis, Ruth C.
dc.contributor.authorFerrari, Pietro
dc.contributor.authorFreisling, Heinz
dc.contributor.authorJenab, Mazda
dc.contributor.authorGunter, Marc J
dc.contributor.authorMurphy, Neil
dc.contributor.authorRiboli, Elio
dc.contributor.authorTjønneland, Anne
dc.contributor.authorBueno-de-Mesquita, H. Bas
dc.date.accessioned2022-05-11T10:51:25Z
dc.date.available2022-05-11T10:51:25Z
dc.date.issued2013-12-07
dc.description.abstractBackground<p> <p>Few studies have investigated the association between whole-grain intake and colorectal cancer. Because whole-grain intake estimation might be prone to measurement errors, more objective measures (eg, biomarkers) could assist in investigating such associations.<p> <p>Methods <p>The association between alkylresorcinols, biomarkers of whole-grain rye and wheat intake, and colorectal cancer incidence were investigated using prediagnostic plasma samples from colorectal cancer case patients and matched control subjects nested within the European Prospective Investigation into Cancer and Nutrition. We included 1372 incident colorectal cancer case patients and 1372 individual matched control subjects and calculated the incidence rate ratios (IRRs) for overall and anatomical subsites of colorectal cancer using conditional logistic regression adjusted for potential confounders. Regional differences (Scandinavia, the Mediterranean, Central Europe) were also explored.<p> <p>Results <p>High plasma total alkylresorcinol concentration was associated with lower incidence of distal colon cancer; the adjusted incidence rate ratio of distal colon cancer for the highest vs lowest quartile of plasma total alkylresorcinols was 0.48 (95% confidence interval [CI] = 0.28 to 0.83). An inverse association between plasma total alkylresorcinol concentrations and colon cancer was found for Scandinavian participants (IRR per doubling = 0.83; 95% CI = 0.70 to 0.98). However, plasma total alkylresorcinol concentrations were not associated with overall colorectal cancer, proximal colon cancer, or rectal cancer. Plasma alkylresorcinols concentrations were associated with colon and distal colon cancer only in Central Europe and Scandinavia (ie, areas where alkylresorcinol levels were higher).<p> <p>Conclusions <p>High concentrations of plasma alkylresorcinols were associated with a lower incidence of distal colon cancer but not with overall colorectal cancer, proximal colon cancer, and rectal cancer.en_US
dc.identifier.citationKyrø C, Olsen A, Landberg R, Skeie G, Loft S, Åman P, Leenders M, Dik VK, Siersema PD, Pischon T, Christensen J, Overvad K, Boutron-Ruault MC, Fagherazzi G, Cottet V, Kühn T, Chang-Claude J, Boeing H, Trichopoulou A, Bamia C, Trichopoulos D, Palli D, Krogh V, Tumino R, Vineis P, Panico S, Peeters PH, Weiderpass E, Bakken T, Åsli la, Arguelles M, Jakszyn P, Sánchez M, Amiano P, Huerta JM, Barricarte A, Ljuslinder I, Palmqvist R, Khaw K, Wareham N, Key TJ, Travis RC, Ferrari P, Freisling H, Jenab M, Gunter MJ, Murphy N, Riboli E, Tjønneland A, Bueno-de-Mesquita HB. Plasma alkylresorcinols, biomarkers of whole-grain wheat and rye intake, and incidence of colorectal cancer. Journal of the National Cancer Institute. 2014;106(1)en_US
dc.identifier.cristinIDFRIDAID 1091429
dc.identifier.doi10.1093/jnci/djt352
dc.identifier.issn0027-8874
dc.identifier.issn1460-2105
dc.identifier.urihttps://hdl.handle.net/10037/25076
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.relation.journalJournal of the National Cancer Institute
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-IDEAS-ERC/232997/EU/TRANSCRIPTOMICS IN CANCER EPIDEMIOLOGY/TICE/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2013 The Author(s)en_US
dc.titlePlasma alkylresorcinols, biomarkers of whole-grain wheat and rye intake, and incidence of colorectal canceren_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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