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dc.contributor.authorTveit, Sjur Hansen
dc.contributor.authorMyhre, Peder Langeland
dc.contributor.authorHanssen, Tove Aminda
dc.contributor.authorForsdahl, Signe Helene
dc.contributor.authorIqbal, Amjid
dc.contributor.authorOmland, Torbjørn
dc.contributor.authorSchirmer, Henrik
dc.date.accessioned2022-05-12T07:51:04Z
dc.date.available2022-05-12T07:51:04Z
dc.date.issued2022-01-18
dc.description.abstractTo compare the performance of high-sensitivity cardiac troponin I and T (hs-cTnI; hs-cTnT) in diagnosing obstructive coronary artery disease (CAD<sub>50</sub>) in patients with suspected chronic coronary syndrome (CCS). A total of 706 patients with suspected CCS, referred for Coronary Computed Tomography Angiography, were included. cTn concentrations were measured using the Singulex hs-cTnI (limit of detection [LoD] 0.08 ng/L) and Roche hs-cTnT (LoD 3 ng/L) assays. Obstructive coronary artery disease (CAD<sub>50</sub>) was defned as ≥ 50% coronary stenosis. Cardiovascular risk was determined by the NORRISK2-score. Median age of the patients was 65 (range 28–87) years, 35% were women. All patients had hs-cTnI concentrations above the LoD (median 1.9 [Q1-3 1.2–3.6] ng/L), 72% had hs-cTnT above the LoD (median 5 [Q1-3 2–11] ng/L). There was a graded relationship between hs-cTn concentrations and coronary artery calcium. Only hs-cTnI remained associated with CAD<sub>50</sub> in adjusted analyses (OR 1.20 95% Confdence Interval [1.05–1.38]), p = 0.009). The C-statistics for hs-cTnI and hs-cTnT were 0.65 (95% CI [0.60–0.69]) and 0.60 (0.56–0.64). The highest specifcity and negative predictive values for CAD<sub>50</sub> were in the lowest NORRISK2-tertile. hs-cTn concentrations provide diagnostic information in patients with suspected CCS, with superior performance of hs-cTnI compared to hs-cTnT in regard to CAD<sub>50</sub>. The diagnostic performance appeared best in those with low cardiovascular risk.en_US
dc.identifier.citationTveit SH, Myhre PL, Hanssen TA, Forsdahl SH, Iqbal A, Omland T, Schirmer H. Cardiac troponin I and T for ruling out coronary artery disease in suspected chronic coronary syndrome. Scientific Reports. 2022;12:945en_US
dc.identifier.cristinIDFRIDAID 1989924
dc.identifier.doi10.1038/s41598-022-04850-7
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/25097
dc.language.isoengen_US
dc.publisherNatureen_US
dc.relation.journalScientific Reports
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleCardiac troponin I and T for ruling out coronary artery disease in suspected chronic coronary syndromeen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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