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dc.contributor.authorZeyen Øyås, Lisa
dc.contributor.authorSeternes, Ole Morten
dc.contributor.authorMikkola, Ingvild
dc.date.accessioned2022-05-13T06:40:03Z
dc.date.available2022-05-13T06:40:03Z
dc.date.issued2022-03-19
dc.description.abstractThe p38 MAPK is a signaling pathway important for cells to respond to environmental and intracellular stress. Upon activation, the p38 kinase phosphorylates downstream effectors, which control the inflammatory response and coordinate fundamental cellular processes such as proliferation, apoptosis, and differentiation. Dysregulation of this signaling pathway has been linked to inflammatory diseases and cancer. Secretion of glucocorticoids (GCs) is a classical endocrine response to stress. The glucocorticoid receptor (GR) is the primary effector of GCs and plays an important role in the regulation of cell metabolism and immune response by influencing gene expression in response to hormone-dependent activation. Its ligands, the GCs or steroids, in natural or synthetic variation, are used as standard therapy for anti-inflammatory treatment, severe asthma, autoimmune diseases, and several types of cancer. Several years ago, the GR was identified as one of the downstream targets of p38, and, at the same time, it was shown that glucocorticoids could influence p38 signaling. In this review, we discuss the role of the crosstalk between the p38 and GR in the regulation of gene expression in response to steroid.en_US
dc.identifier.citationZeyen Øyås, Seternes, Mikkola. Crosstalk between p38 MAPK and GR Signaling. International Journal of Molecular Sciences. 2022;23(6)en_US
dc.identifier.cristinIDFRIDAID 2015746
dc.identifier.doi10.3390/ijms23063322
dc.identifier.issn1661-6596
dc.identifier.issn1422-0067
dc.identifier.urihttps://hdl.handle.net/10037/25107
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalInternational Journal of Molecular Sciences
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.subjectVDP::Medisinske fag: 700en_US
dc.subjectVDP::Midical sciences: 700en_US
dc.subjectInflammasjon / Inflammationen_US
dc.subjectKreft / Canceren_US
dc.titleCrosstalk between p38 MAPK and GR Signalingen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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