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dc.contributor.authorRomieu, Isabelle
dc.contributor.authorScoccianti, Chiara
dc.contributor.authorChajès, Véronique
dc.contributor.authorDe Batlle, Jordi
dc.contributor.authorBiessy, Carine
dc.contributor.authorDossus, Laure
dc.contributor.authorBaglietto, Laura
dc.contributor.authorClavel-Chapelon, Françoise
dc.contributor.authorOvervad, Kim
dc.contributor.authorOlsen, Anja
dc.contributor.authorTjønneland, Anne
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorLukanova, Annekatrin
dc.contributor.authorBoeing, Heiner
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorLagiou, Pagona
dc.contributor.authorTrichopoulos, Dimitrios
dc.contributor.authorPalli, Domenico
dc.contributor.authorSieri, Sabina
dc.contributor.authorTumino, Rosario
dc.contributor.authorVineis, Paolo
dc.contributor.authorPanico, Salvatore
dc.contributor.authorBueno-de-Mesquita, H. Bas
dc.contributor.authorvan Gils, Carla H.
dc.contributor.authorPeeters, Petra H.
dc.contributor.authorLund, Eiliv
dc.contributor.authorSkeie, Guri
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorGarcía, José Ramón Quirós
dc.contributor.authorChirlaque, Maria-Dolores
dc.contributor.authorArdanaz, Eva
dc.contributor.authorSánchez, María-José
dc.contributor.authorDuell, Eric J.
dc.contributor.authorAmiano, Pilar
dc.contributor.authorBorgquist, Signe
dc.contributor.authorWirfält, Elisabet
dc.contributor.authorHallmans, Göran
dc.contributor.authorJohansson, Ingegerd
dc.contributor.authorNilsson, Lena Maria
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorWareham, Nick
dc.contributor.authorKey, Timothy J.
dc.contributor.authorTravis, Ruth C.
dc.contributor.authorMurphy, Neil
dc.contributor.authorWark, Petra A.
dc.contributor.authorFerrari, Pietro
dc.contributor.authorRiboli, Elio
dc.date.accessioned2022-05-19T12:13:08Z
dc.date.available2022-05-19T12:13:08Z
dc.date.issued2015-02-09
dc.description.abstractAlcohol intake has been associated to breast cancer in pre and postmenopausal women; however results are inconclusive regarding tumor hormonal receptor status, and potential modifying factors like age at start drinking. Therefore, we investigated the relation between alcohol intake and the risk of breast cancer using prospective observational data from the European Prospective Investigation into Cancer and Nutrition (EPIC). Up to 334,850 women, aged 35–70 years at baseline, were recruited in ten European countries and followed up an average of 11 years. Alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. The study outcomes were the Hazard ratios (HR) of developing breast cancer according to hormonal receptor status. During 3,670,439 person-years, 11,576 incident breast cancer cases were diagnosed. Alcohol intake was significantly related to breast cancer risk, for each 10 g/day increase in alcohol intake the HR increased by 4.2% (95% CI: 2.7–5.8%). Taking 0 to 5 g/day as reference, alcohol intake of >5 to 15 g/day was related to a 5.9% increase in breast cancer risk (95% CI: 1–11%). Significant increasing trends were observed between alcohol intake and ER1/ PR1, ER2/PR2, HER22 and ER2/PR2HER22 tumors. Breast cancer risk was stronger among women who started drinking prior to first full-time pregnancy. Overall, our results confirm the association between alcohol intake and both hormone receptor positive and hormone receptor negative breast tumors, suggesting that timing of exposure to alcohol drinking may affect the risk. Therefore, women should be advised to control their alcohol consumption.<p> <p>What’s new? <p>Although it is now established that alcohol consumption increases breast cancer risk, many questions remain. Using a prospective study design with 11,576 incident breast cancer cases across 10 European countries, the authors confirmed the increased risk of alcohol on breast cancer development. They further show that women who started drinking before their first full-term pregnancy have a higher risk than women who started afterwards. These effects were observed in hormone-receptor positive and –negative tumors pointing to non-hormonal pathways that need to be further investigated.en_US
dc.identifier.citationRomieu I, Scoccianti, Chajès V, De Batlle, Biessy C, Dossus L, Baglietto L, Clavel-Chapelon F, Overvad K, Olsen A, Tjønneland A, Kaaks R, Lukanova A, Boeing H, Trichopoulou A, Lagiou P, Trichopoulos D, Palli D, Sieri S, Tumino R, Vineis P, Panico S, Bueno-de-Mesquita HB, van Gils CH, Peeters PH, Lund e, Skeie G, Weiderpass E, García, Chirlaque M, Ardanaz E, Sánchez M, Duell EJ, Amiano P, Borgquist S, Wirfält E, Hallmans G, Johansson I, Nilsson LM, Khaw K, Wareham N, Key TJ, Travis RC, Murphy N, Wark PA, Ferrari P, Riboli E. Alcohol intake and breast cancer in the European prospective investigation into cancer and nutrition. International Journal of Cancer. 2015;137(8):1921-1930en_US
dc.identifier.cristinIDFRIDAID 1277827
dc.identifier.doi10.1002/ijc.29469
dc.identifier.issn0020-7136
dc.identifier.issn1097-0215
dc.identifier.urihttps://hdl.handle.net/10037/25227
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalInternational Journal of Cancer
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-IDEAS-ERC/232997/EU/TRANSCRIPTOMICS IN CANCER EPIDEMIOLOGY/TICE/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2015 The Author(s)en_US
dc.titleAlcohol intake and breast cancer in the European prospective investigation into cancer and nutritionen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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