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dc.contributor.authorBlix, Egil Støre
dc.contributor.authorKildal, Anders Benjamin
dc.contributor.authorBertelsen, Eirin Listau
dc.contributor.authorWaage, Anders
dc.contributor.authorMyklebust, June
dc.contributor.authorKolstad, Arne
dc.contributor.authorHusebekk, Anne
dc.date.accessioned2022-06-08T08:14:32Z
dc.date.available2022-06-08T08:14:32Z
dc.date.issued2015-02-14
dc.description.abstractMultiple myeloma (MM) is considered an incurable B cell malignancy, although many patients can benefit from high-dose therapy with autologous stem cell transplantation (ASCT) as a first-line treatment. In nonHodgkin lymphoma (NHL), ASCT is usually performed after relapse with curative intent. Disease progression is often associated with increased angiogenesis, in which endothelial progenitor cells (EPC) may have a central role. Here, we investigated the clinical impact of EPC levels in peripheral blood stem cell (PBSC) autografts for MM and NHL patients who received ASCT. EPC were identified by flow cytometry as aldehyde dehydrogenase<sup>hi</sup> CD34<sup>+</sup> vascular endothelial growth factor receptor 2<sup>+</sup> CD133<sup>+</sup> cells in both MM and NHL autografts. In MM, there was a positive correlation between EPC percentage and serum (s)-b<sub>2</sub>-microglobulin levels (r <sup>2</sup> = .371, P = .002). Unlike for NHL patients, MM patients with high numbers of infused EPC (EPC cells per kilogram) during ASCT had significant shorter progression-free survival (PFS) (P = .035), overall survival (P = .044) and time to next treatment (P = .009). In multivariate analysis, EPC cells per kilogram was a significant independent negative prognostic indicator of PFS (P = .03). In conclusion, the presence of high number of EPC in PBSC grafts is associated with adverse prognosis after ASCT in MM.en_US
dc.identifier.citationBlix ES, Kildal AB, Bertelsen el, Waage A, Myklebust J, Kolstad A, Husebekk A. Content of endothelial progenitor cells in autologous stem cellgrafts predict survival after transplantation for multiplemyeloma. Biology of Blood and Marrow Transplantation. 2015;21(5):840-847en_US
dc.identifier.cristinIDFRIDAID 1236459
dc.identifier.doi10.1016/j.bbmt.2014.12.027
dc.identifier.issn1083-8791
dc.identifier.issn1523-6536
dc.identifier.urihttps://hdl.handle.net/10037/25395
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalBiology of Blood and Marrow Transplantation
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2015 American Society for Blood and Marrow Transplantationen_US
dc.titleContent of endothelial progenitor cells in autologous stem cellgrafts predict survival after transplantation for multiplemyelomaen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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