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dc.contributor.authorStojanovic, Aleksandar
dc.contributor.authorChen, Xiangjun
dc.contributor.authorJin, Nan
dc.contributor.authorZhang, Ting
dc.contributor.authorStojanovic, Filip
dc.contributor.authorRæder, Sten
dc.contributor.authorUtheim, Tor Paaske
dc.date.accessioned2022-06-27T10:10:30Z
dc.date.available2022-06-27T10:10:30Z
dc.date.issued2012-07-30
dc.description.abstractPurpose. To evaluate the efficacy and safety of epithelium-on corneal collagen cross-linking (CXL) using a multifactorial approach to achieve proper stromal riboflavin saturation. Methods. This non-randomized retrospective study comprised 61 eyes with progressive keratoconus treated with epithelium-on CXL. Chemical epithelial penetration enhancement (benzalkonium chloride-containing local medication and hypotonic riboflavin solution), mechanical disruption of the superficial epithelium, and prolongation of the riboflavin-induction time until verification of stromal saturation were used before the UVA irradiation. Uncorrected and corrected distance visual acuity (UDVA, CDVA), refraction, corneal topography, and aberrometry were evaluated at baseline and at 1, 3, 6, and 12 months postoperative. Results. At 12-month, UDVA and CDVA improved significantly. None of the eyes lost lines of CDVA, while 27.4% of the eyes gained 2 or more lines. Mean spherical equivalent decreased by 0.74 D, and mean cylindrical reduction was 1.15 D. Irregularity index and asymmetry from Scheimpflug-based topography and Max-K at the location of cone from Placido-based topography showed a significant decrease. Higher-order-aberration data demonstrated a slight reduction in odd-order aberrations S 3, 5,7 (P = 0.04). Postoperative pain without other complications was recorded. Conclusion. Epithelium-on CXL with our novel protocol appeared to be safe and effective in the treatment of progressive keratoconus.en_US
dc.identifier.citationStojanovic A, Chen X, Jin, Zhang, Stojanovic F, Ræder S, Utheim TP. Safety and efficacy of epithelium-on corneal collagen cross-linking using a multifactorial approach to achieve proper stromal riboflavin saturation. Journal of ophthalmology. 2012en_US
dc.identifier.cristinIDFRIDAID 952573
dc.identifier.doi10.1155/2012/498435
dc.identifier.issn2090-004X
dc.identifier.issn2090-0058
dc.identifier.urihttps://hdl.handle.net/10037/25574
dc.language.isoengen_US
dc.publisherHindawien_US
dc.relation.journalJournal of ophthalmology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2012 The Author(s)en_US
dc.subjectVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Oftalmologi: 754en_US
dc.subjectVDP::Midical sciences: 700::Clinical medical sciences: 750::Ophthalmology: 754en_US
dc.titleSafety and efficacy of epithelium-on corneal collagen cross-linking using a multifactorial approach to achieve proper stromal riboflavin saturationen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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