Show simple item record

dc.contributor.authorYstrøm, Eivind
dc.contributor.authorDegerud, Eirik Magnus Meek
dc.contributor.authorTesli, Martin Steen
dc.contributor.authorHøye, Anne
dc.contributor.authorReichborn-Kjennerud, Ted
dc.contributor.authorNæss, Øyvind Erik
dc.date.accessioned2022-06-28T06:14:24Z
dc.date.available2022-06-28T06:14:24Z
dc.date.issued2022-04-20
dc.description.abstractBackground. A moderate to high alcohol consumption is associated with a lower risk of cardiovascular disease (CVD) mortality in comparison with low consumption. The mechanisms underlying this association are not clear and have been suggested to be caused by residual confounding. The main objective of this study was to separate the familial and individual risk for CVD mortality and all-cause mortality related to alcohol consumption. This will be done by estimating the risk for CVD mortality and all-cause mortality in twin pairs discordant for alcohol consumption.<p> <p>Methods. Alcohol consumption was assessed at two time points using self-report questionnaires in the Norwegian Twin Registry. Data on CVD mortality was obtained from the Norwegian Cause of Death Registry. Exposure–outcome associations for all-cause mortality and mortality due to other causes than CVD were estimated for comparison. <p>Results. Coming from a family with moderate to high alcohol consumption was protective against cardiovascular death (HR = 0.54, 95% CI 0.65–0.83). Moderate and high alcohol consumption levels were associated with a slightly increased risk of CVD mortality at the individual level (HR = 1.33, 95% CI 1.02–1.73). There was no association between alcohol consumption and all-cause mortality both at the familial nor at the individual level. <p>Conclusions. The protective association of moderate to high alcohol consumption with a lower risk of CVD mortality was accounted for by familial factors in this study of twins. Early life genetic and environmental familial factors may mask an absence of health effect of moderate to high alcohol consumption on cardiovascular mortality.en_US
dc.identifier.citationYstrøm E, Degerud EM, Tesli MS, Høye A, Reichborn-Kjennerud T, Næss Ø. Alcohol consumption and lower risk of cardiovascular and all-cause mortality: the impact of accounting for familial factors in twins. Psychological Medicine. 2022en_US
dc.identifier.cristinIDFRIDAID 2035370
dc.identifier.doi10.1017/S0033291722000812
dc.identifier.issn0033-2917
dc.identifier.issn1469-8978
dc.identifier.urihttps://hdl.handle.net/10037/25605
dc.language.isoengen_US
dc.publisherCambridge University Pressen_US
dc.relation.journalPsychological Medicine
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleAlcohol consumption and lower risk of cardiovascular and all-cause mortality: the impact of accounting for familial factors in twinsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record