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dc.contributor.authorAl-ani, Salwan Tariq
dc.contributor.authorSpigt, Marcus
dc.contributor.authorHofset, Per
dc.contributor.authorMelbye, Hasse
dc.date.accessioned2022-06-28T07:22:12Z
dc.date.available2022-06-28T07:22:12Z
dc.date.issued2013-10-10
dc.description.abstractAims. To investigate the incidence of asthma and chronic obstructive pulmonary disease (COPD) exacerbations in primary care during one year and to identify risk factors for such events.<p> <p>Methods. The study was carried out at seven general practice offices in Norway. Patients aged 40 years or more registered with a diagnosis of asthma and/or COPD the previous 5 years were included. After a baseline examination, the participants consulted their GP during exacerbations for the following 12 months. A questionnaire on exacerbations during the follow-up year was distributed to all. Univariable and multivariable logistic regression was performed to determine predictors of future exacerbations. <p>Results. Three hundred and eighty patients attended the baseline examination and complete follow-up data were retrieved from 340 patients. COPD as defined by forced expiratory volume in the first second of expiration/forced vital capacity (FEV1 /FVC) < 0.7, was found in 132 (38.8%) patients. One hundred and fifty-nine patients (46.8%) experienced one exacerbation or more and 101 (29.7%) two exacerbations or more. Patients who had an exacerbation treated with antibiotics or systemic corticosteroids or leading to hospitalization the year before baseline (N = 88) had the highest risk of getting an exacerbation during the subsequent year (odds ratio 9.2), whether the FEV<sub>1</sub> /FVC was below 0.7 or not. Increased risk of future exacerbations was also related to age ≥ 65 years and limitations in social activities, but not to the FEV<sub>1</sub> . <p>Conclusions. The study confirms that previous exacerbations strongly predict future exacerbations in patients with COPD or asthma. Identification and a closer follow-up of patients at risk of such events could promote earlier treatment when necessary and prevent a rapid deterioration of their condition.en_US
dc.identifier.citationAl-ani ST, Spigt M, Hofset, Melbye H. Predictors of exacerbations of asthma and COPD during one year in primary care. Family Practice. 2013;30(6):621-628en_US
dc.identifier.cristinIDFRIDAID 1071503
dc.identifier.doi10.1093/fampra/cmt055
dc.identifier.issn0263-2136
dc.identifier.issn1460-2229
dc.identifier.urihttps://hdl.handle.net/10037/25609
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.relation.journalFamily Practice
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2013 The Author(s)en_US
dc.titlePredictors of exacerbations of asthma and COPD during one year in primary careen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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