Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome: a 10-year follow-up of The Tromso Study
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https://hdl.handle.net/10037/25722Dato
2010-12-28Type
Journal articleTidsskriftartikkel
Peer reviewed
Sammendrag
Many incident cases of type 2 diabetes do not
fulfil the metabolic syndrome, which accordingly has been
questioned both as a research and clinical tool. The aim of
this study was to determine differences in risk factors for
type 2 diabetes between groups with high or low metabolic
score. The study population were 26,093 men and women
attending the Tromsø Study in 1994, followed through
2005, and who did not have diabetes when entering the
study. A total of 492 incident cases of type 2 diabetes were
registered. A metabolic score was defined according to a
modified version of the National Cholesterol Education
Program Adult Treatment Panel III. For those fulfilling C 3 metabolic score criteria, increasing age, body mass
index (BMI), triglycerides and a family history of diabetes
were independent predictors. Age, BMI, and triglycerides
predicted type 2 diabetes more strongly in subjects with
low metabolic score, whereas high HDL cholesterol was
not protective in this low risk group. The risk associated
with a positive family history was unaffected by level of
metabolic score. In addition smoking, low education and in
men also physical inactivity were independent risk factors
only in those with low metabolic score. Adding these nonmetabolic risk factors increased correct classification from
an ROC area of 77.2 to 87.1% (P value \0.0001). One
half of the incident cases of type 2 diabetes were missed by
using high metabolic score for risk prediction.
Forlag
SpringerSitering
Joseph EJ, Svartberg J, Njølstad i, Schirmer H. Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome: a 10-year follow-up of The Tromso Study. European Journal of Epidemiology (EJE). 2011;26(2):117-124Metadata
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