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dc.contributor.authorJoseph, Josepha Elizabeth
dc.contributor.authorSvartberg, Johan
dc.contributor.authorNjølstad, Inger
dc.contributor.authorSchirmer, Henrik
dc.date.accessioned2022-07-01T11:52:18Z
dc.date.available2022-07-01T11:52:18Z
dc.date.issued2010-12-28
dc.description.abstractMany incident cases of type 2 diabetes do not fulfil the metabolic syndrome, which accordingly has been questioned both as a research and clinical tool. The aim of this study was to determine differences in risk factors for type 2 diabetes between groups with high or low metabolic score. The study population were 26,093 men and women attending the Tromsø Study in 1994, followed through 2005, and who did not have diabetes when entering the study. A total of 492 incident cases of type 2 diabetes were registered. A metabolic score was defined according to a modified version of the National Cholesterol Education Program Adult Treatment Panel III. For those fulfilling C 3 metabolic score criteria, increasing age, body mass index (BMI), triglycerides and a family history of diabetes were independent predictors. Age, BMI, and triglycerides predicted type 2 diabetes more strongly in subjects with low metabolic score, whereas high HDL cholesterol was not protective in this low risk group. The risk associated with a positive family history was unaffected by level of metabolic score. In addition smoking, low education and in men also physical inactivity were independent risk factors only in those with low metabolic score. Adding these nonmetabolic risk factors increased correct classification from an ROC area of 77.2 to 87.1% (P value \0.0001). One half of the incident cases of type 2 diabetes were missed by using high metabolic score for risk prediction.en_US
dc.identifier.citationJoseph EJ, Svartberg J, Njølstad i, Schirmer H. Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome: a 10-year follow-up of The Tromso Study. European Journal of Epidemiology (EJE). 2011;26(2):117-124en_US
dc.identifier.cristinIDFRIDAID 802099
dc.identifier.doi10.1007/s10654-010-9540-7
dc.identifier.issn0393-2990
dc.identifier.issn1573-7284
dc.identifier.urihttps://hdl.handle.net/10037/25722
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.journalEuropean Journal of Epidemiology (EJE)
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2010 The Author(s)en_US
dc.titleRisk factors for type 2 diabetes in groups stratified according to metabolic syndrome: a 10-year follow-up of The Tromso Studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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