Antimicrobial activity and mode of action - Examples from natural products, peptides, and peptidomimetics

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https://hdl.handle.net/10037/25912
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Date
2022-08-12
Type
Doctoral thesis
Doktorgradsavhandling

Author
Juskewitz, Eric
Abstract
Infections caused by bacteria are the third leading cause of death worldwide. Antimicrobials are used to treat and prevent those infections and enabled the development of the modern healthcare system as we know it. However, those achievements are threatened by the global emergence of antimicrobial-resistant bacteria. There is an obvious need for developing new antimicrobials. Natural environments, like the Arctic Ocean, offer largely underexplored biodiversity with promising natural antimicrobial products. This thesis investigates marine and marine-inspired molecules for their antibacterial properties and potential applications.
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Paper I: Jenssen, M., Rainsford, P., Juskewitz, E., Andersen, J.H., Hansen, E.H., Isaksson, J., Rämä, T. & Hansen, K.Ø. (2021). Lulworthinone, a new dimeric naphthopyrone from a marine fungus in the family Lulworthiaceae with antibacterial activity against clinical methicillin-resistant Staphylococcus aureus isolates. Frontiers in Microbiology, 12, 2862. Also available in Munin at https://hdl.handle.net/10037/22945.

Paper II: Juskewitz, E., Mishchenko, E., Dubey, V.K., Jenssen, M., Jakubec, M., Rainsford, P., … Ericson, J.U. (2022). Lulworthinone: In vitro mode of action investigation of an antibacterial dimeric, naphthopyrone isolated from a marine fungus. Marine Drugs, 20(5), 277. Also available in Munin at https://hdl.handle.net/10037/25925.

Paper III: Paulsen, M.H., Engqvist, M., Ausbacher, D., Anderssen, T., Langer, M.K., Haug, T., Morello, G.R., Liikanen, L.E., Blencke, H.M., Isaksson, J., Juskewitz, E., Bayer, A. & Strøm, M.B. (2021). Amphipathic barbiturates as mimics of antimicrobial peptides and the marine natural products eusynstyelamides with activity against multi-resistant clinical isolates. Journal of Medicinal Chemistry, 64(15), 11395–11417. Also available in Munin at https://hdl.handle.net/10037/22150.

Paper IV: Karlsen, E.A., Stensen, W., Juskewitz, E., Svenson, J., Berglin, M. & Svendsen, J.S.M. (2021). Anti-colonisation effect of Au surfaces with self-assembled molecular monolayers functionalised with antimicrobial peptides on S. Epidermidis. Antibiotics, 10(12), 1516. Also available in Munin at https://hdl.handle.net/10037/23420.

Related research data
Juskewitz, E. (2022). Replication Data for: "Lulworthinone: In vitro mode of action investigation of an antibacterial dimeric naphthopyrone isolated from a marine fungus." DataverseNO, V1, https://doi.org/10.18710/6Z0VJX.
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UiT The Arctic University of Norway
UiT Norges arktiske universitet
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