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dc.contributor.authorMartiniussen, Marit Almenning
dc.contributor.authorSagstad, Silje
dc.contributor.authorLarsen, Marthe
dc.contributor.authorLarsen, Anne Sofie Frøyshov
dc.contributor.authorHovda, Tone
dc.contributor.authorLee, Christoph I.
dc.contributor.authorHofvind, Solveig Sand-Hanssen
dc.date.accessioned2022-08-04T12:04:24Z
dc.date.available2022-08-04T12:04:24Z
dc.date.issued2022-04-02
dc.description.abstractObjectives - To analyze rates, odds ratios (OR), and characteristics of screen-detected and interval cancers after concordant and discordant initial interpretations and consensus in a population-based screening program.<p> <p>Methods - Data were extracted from the Cancer Registry of Norway for 487,118 women who participated in BreastScreen Norway, 2006–2017, with 2 years of follow-up. All mammograms were independently interpreted by two radiologists, using a score from 1 (negative) to 5 (high suspicion of cancer). A score of 2+ by one of the two radiologists was defined as discordant and 2+ by both radiologists as concordant positive. Consensus was performed on all discordant and concordant positive, with decisions of recall for further assessment or dismiss. OR was estimated with logistic regression with 95% confidence interval (CI), and histopathological tumor characteristics were analyzed for screen-detected and interval cancer.<p> <p>Results - Among screen-detected cancers, 23.0% (697/3024) had discordant scores, while 12.8% (117/911) of the interval cancers were dismissed at index screening. Adjusted OR was 2.4 (95% CI: 1.9–2.9) for interval cancer and 2.8 (95% CI: 2.5–3.2) for subsequent screen-detected cancer for women dismissed at consensus compared to women with concordant negative scores. We found 3.4% (4/117) of the interval cancers diagnosed after being dismissed to be DCIS, compared to 20.3% (12/59) of those with false-positive result after index screening.<p> <p>Conclusion - Twenty-three percent of the screen-detected cancers was scored negative by one of the two radiologists. A higher odds of interval and subsequent screen-detected cancer was observed among women dismissed at consensus compared to concordant negative scores. Our findings indicate a benefit of personalized follow-up.en_US
dc.identifier.citationMartiniussen, Sagstad, Larsen, Larsen, Hovda, Lee, Hofvind. Screen-detected and interval breast cancer after concordant and discordant interpretations in a population based screening program using independent double reading. European Radiology. 2022en_US
dc.identifier.cristinIDFRIDAID 2017713
dc.identifier.doi10.1007/s00330-022-08711-9
dc.identifier.issn0938-7994
dc.identifier.issn1432-1084
dc.identifier.urihttps://hdl.handle.net/10037/25959
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.journalEuropean Radiology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleScreen-detected and interval breast cancer after concordant and discordant interpretations in a population based screening program using independent double readingen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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