Show simple item record

dc.contributor.authorWerner, Maren Caroline Frogner
dc.contributor.authorWirgenes, Katrine Verena
dc.contributor.authorShadrin, Alexey
dc.contributor.authorLunding, Synve Hoffart
dc.contributor.authorRødevand, Linn
dc.contributor.authorHjell, Gabriela
dc.contributor.authorOrmerod, Monica
dc.contributor.authorHaram, Marit
dc.contributor.authorAgartz, Ingrid
dc.contributor.authorDjurovic, Srdjan
dc.contributor.authorMelle, Ingrid
dc.contributor.authorAukrust, Pål
dc.contributor.authorUeland, Thor
dc.contributor.authorAndreassen, Ole
dc.contributor.authorSteen, Nils Eiel
dc.date.accessioned2022-08-16T08:08:08Z
dc.date.available2022-08-16T08:08:08Z
dc.date.issued2022-01-19
dc.description.abstractBackground: Low-grade inflammation may be part of the underlying mechanism of schizophrenia and bipolar disorder. We investigated if genetic susceptibility, infections or autoimmunity could explain the immune activation.<p> <p<Methods: Seven immune markers were selected based on indicated associations to severe mental disorders (IL1Ra, sIL-2R, IL-18, sgp130, sTNFR-1, APRIL, ICAM-1) and measured in plasma of patients with schizophrenia (SCZ, N = 732) and bipolar spectrum disorders (BD, N = 460) and healthy controls (HC, N = 938). Information on rate of infections and autoimmune diseases were obtained from Norwegian national health registries for a twelve-year period. Polygenic risk scores (PRS) of SCZ and BD were calculated from genome-wide association studies. Analysis of covariance were used to test effects of infection rate, autoimmune disease and PRS on differences in immune markers between patients and HC. <p>Results: Infection rate differed between all groups (BD > HC > SCZ, all p < 0.001) whereas autoimmune disease was more frequent in BD compared to SCZ (p = 0.004) and HC (p = 0.003). sIL-2R was positively associated with autoimmune disease (p = 0.001) and negatively associated with PRS of SCZ (p = 0.006) across SCZ and HC; however, associations represented only small changes in the difference of sIL-2R levels between SCZ and HC. <p>Conclusion: There were few significant associations between rate of infections, autoimmune disease or PRS and altered immune markers in SCZ and BD, and the detected associations represented only small changes in the immune aberrations. The findings suggest that most of the low-grade inflammation in SCZ and BD is explained by other factors than the underlying PRS, autoimmunity and infection rates.en_US
dc.identifier.citationWerner, Wirgenes, Shadrin, Lunding, Rødevand, Hjell, Ormerod, Haram, Agartz, Djurovic, Melle, Aukrust, Ueland, Andreassen, Steen. Limited association between infections, autoimmune disease and genetic risk and immune activation in severe mental disorders. Progress in Neuro-psychopharmacology and Biological Psychiatry. 2022;116en_US
dc.identifier.cristinIDFRIDAID 2019714
dc.identifier.doi10.1016/j.pnpbp.2022.110511
dc.identifier.issn0278-5846
dc.identifier.issn1878-4216
dc.identifier.urihttps://hdl.handle.net/10037/26205
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalProgress in Neuro-psychopharmacology and Biological Psychiatry
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleLimited association between infections, autoimmune disease and genetic risk and immune activation in severe mental disordersen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record