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dc.contributor.authorStikbakke, Einar
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorHaugnes, Hege Sagstuen
dc.contributor.authorPedersen, Mona Irene
dc.contributor.authorKnutsen, Tore
dc.contributor.authorStøyten, Martin
dc.contributor.authorGiovannucci, Edward
dc.contributor.authorEggen, Anne Elise
dc.contributor.authorThune, Inger
dc.contributor.authorRichardsen, Elin
dc.date.accessioned2022-08-17T12:12:22Z
dc.date.available2022-08-17T12:12:22Z
dc.date.issued2022-02-23
dc.description.abstractThe role of miR-24-1-5p and its prognostic implications associated with prostate cancer are mainly unknown. In a population-based cohort, the Prostate Cancer Study throughout life (PROCA-life), all men had a general health examination at study entry and were followed between 1994 and 2016. Patients with available tissue samples after a prostatectomy with curative intent were identified (n = 189). The tissue expression of miR-24-1-5p in prostate cancer was examined by in situ hybridization (ISH) in tissue microarray (TMA) blocks by semi-quantitative scoring by two independent investigators. Multivariable Cox regression models were used to study the associations between miR-24-1-5p expression and prostate cancer recurrence. The prostate cancer patients had a median age of 65.0 years (range 47–75 years). The Cancer of the Prostate Risk Assessment Postsurgical Score, International Society of Urological Pathology grade group, and European Association of Urology Risk group were all significant prognostic factors for five-year recurrence-free survival (p < 0.001). Prostate cancer patients with a high miR-24-1-5p expression (≥1.57) in the tissue had a doubled risk of recurrence compared to patients with low expression (HR 1.99, 95% CI 1.13–3.51). Our study suggests that a high expression of miR-24-1-5p is associated with an increased risk of recurrence of prostate cancer after radical prostatectomy, which points to the potential diagnostic and therapeutic value of detecting miR-24-1-5p in prostate cancer cases.en_US
dc.identifier.citationStikbakke, Wilsgaard, Haugnes, Pedersen, Knutsen, Støyten, Giovannucci, Eggen, Thune, Richardsen. Expression of miR-24-1-5p in Tumor Tissue Influences Prostate Cancer Recurrence: The PROCA-life Study. Cancers. 2022;14(5)en_US
dc.identifier.cristinIDFRIDAID 2026967
dc.identifier.doi10.3390/cancers14051142
dc.identifier.issn2072-6694
dc.identifier.urihttps://hdl.handle.net/10037/26248
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalCancers
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleExpression of miR-24-1-5p in Tumor Tissue Influences Prostate Cancer Recurrence: The PROCA-life Studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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