Show simple item record

dc.contributor.authorMundal, Siv Boon
dc.contributor.authorRakner, Johanne Johnsen
dc.contributor.authorSilva, Gabriela
dc.contributor.authorGierman, Lobke
dc.contributor.authorAustdal, Marie
dc.contributor.authorBasnet, Purusotam
dc.contributor.authorElschot, Mattijs
dc.contributor.authorBakke, Siril Skaret
dc.contributor.authorOstrop, Jenny
dc.contributor.authorThomsen, Liv Cecilie Vestrheim
dc.contributor.authorMoses, Eric
dc.contributor.authorAcharya, Ganesh
dc.contributor.authorBjørge, Line
dc.contributor.authorIversen, Ann-Charlotte
dc.date.accessioned2022-08-18T08:15:42Z
dc.date.available2022-08-18T08:15:42Z
dc.date.issued2022-02-10
dc.description.abstractUtero-placental development in pregnancy depends on direct maternal–fetal interaction in the uterine wall decidua. Abnormal uterine vascular remodeling preceding placental oxidative stress and placental dysfunction are associated with preeclampsia and fetal growth restriction (FGR). Oxidative stress is counteracted by antioxidants and oxidative repair mechanisms regulated by the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2). We aimed to determine the decidual regulation of the oxidative-stress response by NRF2 and its negative regulator Kelch-like ECH-associated protein 1 (KEAP1) in normal pregnancies and preeclamptic pregnancies with and without FGR. Decidual tissue from 145 pregnancies at delivery was assessed for oxidative stress, non-enzymatic antioxidant capacity, cellular NRF2- and KEAP1-protein expression, and NRF2-regulated transcriptional activation. Preeclampsia combined with FGR was associated with an increased oxidative-stress level and NRF2-regulated gene expression in the decidua, while decidual NRF2- and KEAP1-protein expression was unaffected. Although preeclampsia with normal fetal growth also showed increased decidual oxidative stress, NRF2-regulated gene expression was reduced, and KEAP1-protein expression was increased in areas of high trophoblast density. The trophoblast-dependent KEAP1-protein expression in preeclampsia with normal fetal growth indicates control of decidual oxidative stress by maternal–fetal interaction and underscores the importance of discriminating between preeclampsia with and without FGR.en_US
dc.identifier.citationMundal, Rakner, Silva, Gierman, Austdal, Basnet, Elschot, Bakke, Ostrop, Thomsen, Moses, Acharya, Bjørge, Iversen. Divergent Regulation of Decidual Oxidative-Stress Response by NRF2 and KEAP1 in Preeclampsia with and without Fetal Growth Restriction. International Journal of Molecular Sciences. 2022;23(4)en_US
dc.identifier.cristinIDFRIDAID 2019409
dc.identifier.doi10.3390/ijms23041966
dc.identifier.issn1661-6596
dc.identifier.issn1422-0067
dc.identifier.urihttps://hdl.handle.net/10037/26265
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalInternational Journal of Molecular Sciences
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleDivergent Regulation of Decidual Oxidative-Stress Response by NRF2 and KEAP1 in Preeclampsia with and without Fetal Growth Restrictionen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record