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dc.contributor.authorBouziotis, Jason
dc.contributor.authorArvanitakis, Marianna
dc.contributor.authorPreiser, Jean-Charles
dc.contributor.authorAbbas, Ali
dc.contributor.authorAbdukahil, Sheryl Ann
dc.contributor.authorAbdulkadir, Nurul Najmee
dc.contributor.authorAbe, Ryuzo
dc.contributor.authorAbel, Laurent
dc.contributor.authorAbsil, Lara
dc.contributor.authorAcharya, Subhash
dc.contributor.authorAcker, Andrew
dc.contributor.authorAdachi, Shingo
dc.contributor.authorAdam, Elisabeth
dc.contributor.authorAdrião, Diana
dc.contributor.authorAl Ageel, Saleh
dc.contributor.authorAhmed, Shakeel
dc.contributor.authorAin, Quratul
dc.contributor.authorAinscough, Kate
dc.contributor.authorAisa, Tharwat
dc.contributor.authorBerdal, Jan-Erik
dc.contributor.authorDudman, Susanne Gjeruldsen
dc.contributor.authorDyrhol-Riise, Anne Ma
dc.contributor.authorSkeie, Linda Gail
dc.contributor.authorHeggelund, Lars
dc.contributor.authorHesstvedt, Liv
dc.contributor.authorHolter, Jan Cato
dc.contributor.authorJenum, Synne
dc.contributor.authorJohal, Simreen Kaur
dc.contributor.authorKildal, Anders Benjamin
dc.contributor.authorBekken, Gry Klouman
dc.contributor.authorLind, Andreas
dc.contributor.authorMüller, Fredrik
dc.contributor.authorMuller, Karl Erik
dc.contributor.authorPettersen, Frank O.
dc.contributor.authorPaulsen, Else Quist
dc.contributor.authorReikvam, Dag Henrik
dc.contributor.authorHolten, Aleksander Rygh
dc.contributor.authorSkogen, Vegard
dc.contributor.authorStiksrud, Birgitte
dc.contributor.authorTonby, Kristian
dc.date.accessioned2022-08-18T09:03:10Z
dc.date.available2022-08-18T09:03:10Z
dc.date.issued2022-01-29
dc.description.abstractBackground: Patients with extreme body mass indices (BMI) could have an increased risk of death while hospitalized for COVID-19.<p> <p>Methods: The database of the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) was used to assess the time to in-hospital death with competing-risks regression by sex and between the categories of BMI. <p>Results: Data from 12,137 patients (age 60.0 ± 16.2 years, 59% males, BMI 29.4 ± 6.9 kg/m<sup>2</sup> ) of 48 countries were available. By univariate analysis, underweight patients had a higher risk of mortality than the other patients (sub-hazard ratio (SHR) 1.75 [1.44e2.14]). Mortality was lower in normal (SHR 0.69 [0.58e0.85]), overweight (SHR 0.53 [0.43e0.65]) and obese (SHR 0.55 [0.44e0.67]) than in underweight patients. Multivariable analysis (adjusted for age, chronic pulmonary disease, malignant neoplasia, type 2 diabetes) confirmed that in-hospital mortality of underweight patients was higher than overweight patients (females: SHR 0.63 [0.45e0.88] and males: 0.69 [0.51e0.94]). <p>Conclusion: Even though these findings do not imply changes in the medical care of hospitalized patients, they support the use of BMI category for the stratification of patients enrolled in interventional studies where mortality is recorded as an outcome.en_US
dc.identifier.citationBouziotis, Arvanitakis M, Preiser J, Abbas A, Abdukahil SA, Abdulkadir NN, Abe R, Abel L, Absil L, Acharya S, Acker A, Adachi S, Adam E, Adrião D, Al Ageel S, Ahmed S, Ain, Ainscough K, Aisa, Berdal JE, Dudman SG, Dyrhol-Riise AM, Skeie Lg, Heggelund L, Hesstvedt L, Holter JC, Jenum S, Johal SK, Kildal AB, Bekken GK, Lind AL, Müller F, Muller KE, Pettersen FO, Paulsen EL, Reikvam DH, Holten AR, Skogen V, Stiksrud B, Tonby K. Association of body mass index with COVID-19 related in-hospital death. Clinical Nutrition. 2022en_US
dc.identifier.cristinIDFRIDAID 2037259
dc.identifier.doi10.1016/j.clnu.2022.01.017
dc.identifier.issn0261-5614
dc.identifier.issn1532-1983
dc.identifier.urihttps://hdl.handle.net/10037/26273
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalClinical Nutrition
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleAssociation of body mass index with COVID-19 related in-hospital deathen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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