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dc.contributor.authorMukama, Trasias
dc.contributor.authorFortner, Renée Turzanski
dc.contributor.authorKatzke, Verena
dc.contributor.authorHynes, Lucas Cory
dc.contributor.authorPetrera, Agnese
dc.contributor.authorHauck, Stefanie M.
dc.contributor.authorJohnson, Theron
dc.contributor.authorSchulze, Matthias
dc.contributor.authorSchiborn, Catarina
dc.contributor.authorRostgaard-Hansen, Agnetha Linn
dc.contributor.authorTjønneland, Anne
dc.contributor.authorOvervad, Kim
dc.contributor.authorPérez, María José Sánchez
dc.contributor.authorCrous-Bou, Marta
dc.contributor.authorChirlaque, María-Dolores
dc.contributor.authorAmiano, Pilar
dc.contributor.authorArdanaz, Eva
dc.contributor.authorWatts, Eleanor L.
dc.contributor.authorTravis, Ruth C.
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorGrioni, Sara
dc.contributor.authorMasala, Giovanna
dc.contributor.authorSignoriello, Simona
dc.contributor.authorTumino, Rosario
dc.contributor.authorGram, Inger Torhild
dc.contributor.authorSandanger, Torkjel M
dc.contributor.authorSartor, Hanna
dc.contributor.authorLundin, Eva
dc.contributor.authorIdahl, Annika
dc.contributor.authorHeath, Alicia K.
dc.contributor.authorDossus, Laure
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorKaaks, Rudolf
dc.date.accessioned2022-08-24T10:15:18Z
dc.date.available2022-08-24T10:15:18Z
dc.date.issued2022-01-14
dc.description.abstractBACKGROUND: CA125 is the best available yet insufficiently sensitive biomarker for early detection of ovarian cancer. There is a need to identify novel biomarkers, which individually or in combination with CA125 can achieve adequate sensitivity and specificity for the detection of earlier-stage ovarian cancer.<p> <p>METHODS: In the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we measured serum levels of 92 preselected proteins for 91 women who had blood sampled ≤18 months prior to ovarian cancer diagnosis, and 182 matched controls. We evaluated the discriminatory performance of the proteins as potential early diagnostic biomarkers of ovarian cancer. <p>RESULTS: Nine of the 92 markers; CA125, HE4, FOLR1, KLK11, WISP1, MDK, CXCL13, MSLN and ADAM8 showed an area under the ROC curve (AUC) of ≥0.70 for discriminating between women diagnosed with ovarian cancer and women who remained cancerfree. All, except ADAM8, had shown at least equal discrimination in previous case-control comparisons. The discrimination of the biomarkers, however, was low for the lag-time of >9–18 months and paired combinations of CA125 with any of the 8 markers did not improve discrimination compared to CA125 alone. <p>CONCLUSION: Using pre-diagnostic serum samples, this study identified markers with good discrimination for the lag-time of 0–9 months. However, the discrimination was low in blood samples collected more than 9 months prior to diagnosis, and none of the markers showed major improvement in discrimination when added to CA125.en_US
dc.identifier.citationMukama, Fortner, Katzke, Hynes, Petrera, Hauck, Johnson, Schulze, Schiborn, Rostgaard-Hansen, Tjønneland, Overvad, Pérez, Crous-Bou, Chirlaque, Amiano, Ardanaz, Watts, Travis, Sacerdote, Grioni, Masala, Signoriello, Tumino, Gram, Sandanger, Sartor, Lundin, Idahl, Heath, Dossus, Weiderpass, Kaaks. Prospective evaluation of 92 serum protein biomarkers for early detection of ovarian cancer. British Journal of Cancer. 2022;126(9):1301-1309en_US
dc.identifier.cristinIDFRIDAID 2023600
dc.identifier.doi10.1038/s41416-021-01697-z
dc.identifier.issn0007-0920
dc.identifier.issn1532-1827
dc.identifier.urihttps://hdl.handle.net/10037/26372
dc.language.isoengen_US
dc.publisherNatureen_US
dc.relation.journalBritish Journal of Cancer
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleProspective evaluation of 92 serum protein biomarkers for early detection of ovarian canceren_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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