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dc.contributor.authorPrezioso, Carla
dc.contributor.authorBrazzini, Gabriele
dc.contributor.authorPasserini, Sara
dc.contributor.authorDi Fabio, Carlotta
dc.contributor.authorCosio, Terenzio
dc.contributor.authorBernardini, Sergio
dc.contributor.authorCampione, Elena
dc.contributor.authorMoens, Ugo
dc.contributor.authorPietropaolo, Valeria
dc.contributor.authorCiotti, Marco
dc.date.accessioned2022-08-30T07:51:53Z
dc.date.available2022-08-30T07:51:53Z
dc.date.issued2022-02-18
dc.description.abstractTo date, 14 human polyomaviruses (HPyVs) have been identified using high-throughput technologies. Among them, MCPyV, HPyV6, HPyV7 and TSPyV present a skin tropism, but a causal role in skin diseases has been established only for MCPyV as a causative agent of Merkel cell carcinoma (MCC) and TSPyV as an etiological agent of Trichodysplasia Spinulosa (TS). In the search for a possible role for cutaneous HPyVs in the development of skin malignant lesions, we investigated the prevalence of MCPyV, HPyV6, HPyV7 and TSPyV in actinic keratosis (AK), a premalignant skin lesion that has the potential to progress towards a squamous cell carcinoma (SCC). One skin lesion and one non-lesion skin from nine affected individuals were analyzed by qualitative PCR. MCPyV was detected in 9 out of 9 lesion biopsies and 6 out of 8 non-lesion biopsies. HPyV6 was detected only in healthy skin, while HPyV7 and TSPyV were not detected in any skin sample. These findings argue against a possible role of cutaneous HPyVs in AK. However, considering the small sample size analyzed, a definitive conclusion cannot be drawn. Longitudinal studies on large cohorts are warranted.en_US
dc.identifier.citationPrezioso C, Brazzini G, Passerini S, Di Fabio, Cosio, Bernardini S, Campione, Moens u, Pietropaolo V, Ciotti M. Prevalence of MCPyV, HPyV6, HPyV7 and TSPyV in Actinic Keratosis Biopsy Specimens. Viruses. 2022;14(2)en_US
dc.identifier.cristinIDFRIDAID 2019078
dc.identifier.doi10.3390/v14020427
dc.identifier.issn1999-4915
dc.identifier.urihttps://hdl.handle.net/10037/26464
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalViruses
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titlePrevalence of MCPyV, HPyV6, HPyV7 and TSPyV in Actinic Keratosis Biopsy Specimensen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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