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dc.contributor.authorHeitmann, Kim Arne
dc.contributor.authorWelde, Boye
dc.contributor.authorLøchen, Maja-Lisa
dc.contributor.authorStylidis, Michael
dc.contributor.authorSchirmer, Henrik
dc.contributor.authorMorseth, Bente
dc.date.accessioned2022-09-07T07:55:44Z
dc.date.available2022-09-07T07:55:44Z
dc.date.issued2022-05-12
dc.description.abstractBackground: Current knowledge about the relationship between physical activity (PA) and cardiac remodeling is mainly derived from cross-sectional studies of athletes, and there is a knowledge gap of this association in the general adult and elderly population. Therefore, we aimed to explore the longitudinal association between cumulative PA and change in cardiac structure and function in a general adult and elderly population.<p> <p>Methods: This longitudinal study includes 594 participants from the sixth (Tromsø6, 2007–08) and seventh (Tromsø7, 2015–16) survey of the Tromsø Study. Cardiac structure and function were assessed by echocardiography at two time points, and PA was self-reported by questionnaire at both time points. PA volume was expressed as cumulative PA (Low, Moderate, and Hard) and the association with left atrial (LA) and left ventricular (LV) structure and function was assessed using ANCOVA. <p>Results: Overall, LA diameter index (LADi) increased significantly more in Hard compared to Moderate PA (+0.08 cm/m<sup>2</sup> , 95% CI 0.01–0.15, p = 0.020) from Tromsø6 to Tromsø7. When stratified by sex or age, higher levels of cumulative PA were associated with increased LADi in males and in participants <65 years only. Indexed LV mass (LVMi) increased significantly more in Moderate than in Low PA (+3.9 g/m<sup>2.7</sup>, 95% CI 0.23– 7.57, p = 0.037). When stratified by sex or age, these changes in LVMi and indexed LV diameter (LVDi) were only significant in females. No significant associations were observed between cumulative PA and change in relative wall thickness, E/e’ ratio, e’ velocity, LV ejection fraction, and LADi/LVDi ratio. <p>Conclusion: Higher levels of cumulative PA were associated with increased LADi in males and participants <65 years, and with increased LVMi and LVDi in females. Despite cardiac chamber enlargement, the pump function of the heart did not change with higher levels of PA, and the atrioventricular ratio was unchanged. Our results indicate that cardiac chamber enlargement is a physiological response to PA.en_US
dc.identifier.citationHeitmann KA, Welde B, Løchen M, Stylidis S, Schirmer H, Morseth B. Longitudinal Associations Between Cumulative Physical Activity and Change in Structure and Function of the Left Side of the Heart: The Tromsø Study 2007–2016. Frontiers in Cardiovascular Medicine. 2022;9:1-12en_US
dc.identifier.cristinIDFRIDAID 2023814
dc.identifier.doi10.3389/fcvm.2022.882077
dc.identifier.issn2297-055X
dc.identifier.urihttps://hdl.handle.net/10037/26702
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.ispartofHeitmann, K.A. (2023). Physical activity and the structure and function of the left side of the heart. (Doctoral thesis). <a href=https://hdl.handle.net/10037/28634>https://hdl.handle.net/10037/28634</a>.
dc.relation.journalFrontiers in Cardiovascular Medicine
dc.relation.urihttps://www.frontiersin.org/articles/10.3389/fcvm.2022.882077/full
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.subjectVDP::Medisinske fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803en_US
dc.subjectVDP::Midical sciences: 700::Health sciences: 800::Epidemiology, medical and dental statistics: 803en_US
dc.subjectVDP::Medisinske fag: 700::Idrettsmedisinske fag: 850en_US
dc.subjectVDP::Midical sciences: 700::Sports medicine: 850en_US
dc.subjectVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771en_US
dc.subjectVDP::Midical sciences: 700::Clinical medical sciences: 750::Cardiology: 771en_US
dc.titleLongitudinal Associations Between Cumulative Physical Activity and Change in Structure and Function of the Left Side of the Heart: The Tromsø Study 2007–2016en_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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