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dc.contributor.authorFang, Jui
dc.contributor.authorLai, Ming-Wei
dc.contributor.authorCheng, Hao-Tsai
dc.contributor.authorCristea, Anca
dc.contributor.authorZhou, Zhuhuang
dc.contributor.authorTsui, Po-Hsiang
dc.date.accessioned2022-09-08T10:47:07Z
dc.date.available2022-09-08T10:47:07Z
dc.date.issued2022-03-29
dc.description.abstractHepatic steatosis causes nonalcoholic fatty liver disease. Whole-body vibration (WBV) has been recommended to allow patients who have difficulty engaging in exercise to improve the grade of hepatic steatosis. This study proposed using ultrasound parametric imaging of the homodyned K (HK) distribution to evaluate the effectiveness of WBV treatments in alleviating hepatic steatosis. Sixty mice were assigned to control (n = 6), sedentary (n = 18), WBV (n = 18), and exercise (swimming) (n = 18) groups. Mice were fed a high-fat diet to induce hepatic steatosis and underwent the intervention for 4, 8, and 16 weeks. Ultrasound scanning was performed in vivo on each mouse after the interventions for ultrasound HK imaging using the parameter μ (the scatterer clustering parameter). Histopathological examinations and the intraperitoneal glucose tolerance test were carried out for comparisons with ultrasound findings. At the 16th week, WBV and exercise groups demonstrated lower body weights, glucose concentrations, histopathological scores (steatosis and steatohepatitis), and μ parameters than the control group (p < 0.05). The steatosis grade was significantly lower in the WBV group (mild) than in the exercise group (moderate) (p < 0.05), corresponding to a reduction in the μ parameter. A further analysis revealed that the correlation between the steatosis grade and the μ parameter was 0.84 (p < 0.05). From this animal study we conclude that WBV may be more effective than exercise in reducing the progression of hepatic steatosis, and ultrasound HK parametric imaging is an appropriate method for evaluating WBV’s effect on hepatic steatosis.en_US
dc.identifier.citationFang, Lai, Cheng, Cristea, Zhou, Tsui. Imaging the Effects of Whole-Body Vibration on the Progression of Hepatic Steatosis by Quantitative Ultrasound Based on Backscatter Envelope Statistics. Pharmaceutics. 2022;14(4)en_US
dc.identifier.cristinIDFRIDAID 2029771
dc.identifier.doi10.3390/pharmaceutics14040741
dc.identifier.issn1999-4923
dc.identifier.urihttps://hdl.handle.net/10037/26724
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalPharmaceutics
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleImaging the Effects of Whole-Body Vibration on the Progression of Hepatic Steatosis by Quantitative Ultrasound Based on Backscatter Envelope Statisticsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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