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dc.contributor.authorJørgensen, Helle
dc.contributor.authorHorváth-Puhó, Erzsébet
dc.contributor.authorLaugesen, Kristina
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.contributor.authorHansen, John Bjarne
dc.contributor.authorSørensen, Henrik Toft
dc.date.accessioned2022-09-08T11:04:24Z
dc.date.available2022-09-08T11:04:24Z
dc.date.issued2022-04-14
dc.description.abstractBackground: Venous thromboembolism (VTE) is associated with increased risk of disability pension. How socioeconomic status (SES) impacts the risk of disability pension after a VTE is unknown. The aim of this nationwide population based cohort study to investigate the interaction between SES and incident VTE on the risk of subsequent disability pension.<p> <p>Methods: Using Danish national medical and administrative databases, we established a nationwide cohort of 41,781 individuals aged 25– 65 years with incident VTE during 1995– 2016 and a comparison cohort (n=208,905) from the general population matched on year of birth, sex, and calendar year of VTE. We computed incidence rates (IRs) as the number of disability pension events per 1000 person-years at risk and measured the interaction between VTE and levels of SES (high, medium, low) on an additive scale by calculating interaction contrasts (difference in IR difference).<p> <p>Results: Among individuals with high SES, the disability pension IR per 1000 person-years was 5.4 (95% CI: 4.8– 6.1) in the VTE cohort and 1.6 (95% CI: 1.5– 1.7) in the comparison cohort (IR difference 3.8). The corresponding disability pension IR in individuals with low SES was 55.1 (95% CI: 52.1– 58.1) in the VTE cohort and 26.1 (95% CI: 25.1– 27.1) in the comparison cohort (IR difference 24.0). An interaction contrast of 25.1 indicated that interaction accounted for 45.6% (25.1/55.1) of the disability pension IR in individuals with VTE and low SES.<p> <p>Conclusion: SES and VTE interact to increase the risk of disability pension after VTE beyond their independent effects.en_US
dc.identifier.citationJørgensen, Horváth-Puhó, Laugesen, Brækkan, Hansen, Sørensen. The Interaction Between Venous Thromboembolism and Socioeconomic Status on the Risk of Disability Pension. Clinical Epidemiology. 2022;14:489-500en_US
dc.identifier.cristinIDFRIDAID 2024599
dc.identifier.doi10.2147/CLEP.S361840
dc.identifier.issn1179-1349
dc.identifier.urihttps://hdl.handle.net/10037/26729
dc.language.isoengen_US
dc.publisherDove Pressen_US
dc.relation.ispartofJørgensen, H. (2022). The impact of socioeconomic status on the risk and prognosis of venous thromboembolism. (Doctoral thesis). <a href=https://hdl.handle.net/10037/27047>https://hdl.handle.net/10037/27047</a>.
dc.relation.journalClinical Epidemiology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleThe Interaction Between Venous Thromboembolism and Socioeconomic Status on the Risk of Disability Pensionen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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