MyD88 interacts with interferon regulatory factor (IRF) 3 and IRF7 in Atlantic salmon (Salmo salar): transgenic SsMyD88 modulates the IRF-induced type I interferon response and accumulates in aggresomes

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https://hdl.handle.net/10037/26792
DOI
https://doi.org/10.1074/jbc.M111.293969
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Date
2011-10-11
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Iliev, Dimitar Borisov; Sobhkhez, Mehrdad; Fremmerlid, Kjersti Kongsgården; Jørgensen, Jorunn B
Abstract
Background: MyD88 directly interacts and affects IRF activation in mammals, but no information has been available about lower vertebrates.

Results: Transgenic MyD88 interacts with IRF3 and IRF7A/B and modulates the IRF-induced IFN response and accumulates in aggresomes in Atlantic salmon.

Conclusion: MyD88 is involved in the regulation of the IRF-induced IFN response in Atlantic salmon. Significance: The results shed light on the evolution of the innate immune response in vertebrates.

Publisher
Elsevier
Citation
Iliev DB, Sobhkhez M, Fremmerlid KK, Jørgensen JB. MyD88 interacts with interferon regulatory factor (IRF) 3 and IRF7 in Atlantic salmon (Salmo salar): transgenic SsMyD88 modulates the IRF-induced type I interferon response and accumulates in aggresomes. Journal of Biological Chemistry. 2011;286(49):42715-42724
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Copyright 2011 American Society for Biochemistry and Molecular Biology