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dc.contributor.authorPage, Christian Magnus
dc.contributor.authorNøst, Therese Haugdahl
dc.contributor.authorDjordjilović, Vera
dc.contributor.authorThoresen, Magne
dc.contributor.authorFrigessi, Arnoldo
dc.contributor.authorSandanger, Torkjel M
dc.contributor.authorVeierød, Marit Bragelien
dc.date.accessioned2022-11-30T14:54:27Z
dc.date.available2022-11-30T14:54:27Z
dc.date.issued2022-08-20
dc.description.abstractThe prognosis of cutaneous melanoma depends on early detection, and good biomarkers for melanoma risk may provide a valuable tool to detect melanoma development at a pre-clinical stage. By studying the epigenetic profile in pre-diagnostic blood samples of melanoma cases and cancer free controls, we aimed to identify DNA methylation sites conferring melanoma risk. DNA methylation was measured at 775,528 CpG sites using the Illumina EPIC array in whole blood in incident melanoma cases (n = 183) and matched cancer-free controls (n = 183) in the Norwegian Women and Cancer cohort. Phenotypic information and ultraviolet radiation exposure were obtained from questionnaires. Epigenome wide association (EWAS) was analyzed in future melanoma cases and controls with conditional logistic regression, with correction for multiple testing using the false discovery rate (FDR). We extended the analysis by including a public data set on melanoma (GSE120878), and combining these different data sets using a version of covariate modulated FDR (AdaPT). The analysis on future melanoma cases and controls did not identify any genome wide significant CpG sites (0.85 ≤ padj ≤ 0.99). In the restricted AdaPT analysis, 7 CpG sites were suggestive at the FDR level of 0.15. These CpG sites may potentially be used as pre-diagnostic biomarkers of melanoma risk.en_US
dc.identifier.citationPage, Nøst, Djordjilović, Thoresen, Frigessi, Sandanger, Veierød. Pre-diagnostic DNA methylation in blood leucocytes in cutaneous melanoma; a nested case–control study within the Norwegian Women and Cancer cohort. Scientific Reports. 2022;12(1)en_US
dc.identifier.cristinIDFRIDAID 2054092
dc.identifier.doi10.1038/s41598-022-18585-y
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/27622
dc.language.isoengen_US
dc.publisherBMJ Publishing Groupen_US
dc.relation.journalScientific Reports
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titlePre-diagnostic DNA methylation in blood leucocytes in cutaneous melanoma; a nested case–control study within the Norwegian Women and Cancer cohorten_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)