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dc.contributor.authorZolotarov, Grygoriy
dc.contributor.authorFromm, Bastian
dc.contributor.authorLegnini, Ivano
dc.contributor.authorAyoub, Salah
dc.contributor.authorPolese, Gianluca
dc.contributor.authorMaselli, Valeria
dc.contributor.authorChabot, Peter J.
dc.contributor.authorVinther, Jakob
dc.contributor.authorStyfhals, Ruth
dc.contributor.authorSeuntjens, Eve
dc.contributor.authorDi Cosmo, Anna
dc.contributor.authorPeterson, Kevin J.
dc.contributor.authorRajewsky, Nikolaus
dc.date.accessioned2023-01-10T12:07:34Z
dc.date.available2023-01-10T12:07:34Z
dc.date.issued2022-11-25
dc.description.abstractSoft-bodied cephalopods such as octopuses are exceptionally intelligent invertebrates with a highly complex nervous system that evolved independently from vertebrates. Because of elevated RNA editing in their nervous tissues, we hypothesized that RNA regulation may play a major role in the cognitive success of this group. We thus profiled messenger RNAs and small RNAs in three cephalopod species including 18 tissues of the Octopus vulgaris. We show that the major RNA innovation of soft-bodied cephalopods is an expansion of the microRNA (miRNA) gene repertoire. These evolutionarily novel miRNAs were primarily expressed in adult neuronal tissues and during the development and had conserved and thus likely functional target sites. The only comparable miRNA expansions happened, notably, in vertebrates. Thus, we propose that miRNAs are intimately linked to the evolution of complex animal brains.en_US
dc.identifier.citationZolotarov, Fromm, Legnini, Ayoub, Polese, Maselli, Chabot, Vinther, Styfhals, Seuntjens, Di Cosmo, Peterson, Rajewsky. MicroRNAs are deeply linked to the emergence of the complex octopus brain. Science Advances. 2022;8(47)en_US
dc.identifier.cristinIDFRIDAID 2094244
dc.identifier.doi10.1126/sciadv.add9938
dc.identifier.issn2375-2548
dc.identifier.urihttps://hdl.handle.net/10037/28117
dc.language.isoengen_US
dc.publisherAmerican Association for the Advancement of Scienceen_US
dc.relation.journalScience Advances
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleMicroRNAs are deeply linked to the emergence of the complex octopus brainen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)