dc.contributor.author | Nieder, Carsten | |
dc.contributor.author | Haukland, Ellinor Christin | |
dc.contributor.author | Mannsåker, Bård | |
dc.date.accessioned | 2023-01-18T08:30:37Z | |
dc.date.available | 2023-01-18T08:30:37Z | |
dc.date.issued | 2022-01-25 | |
dc.description.abstract | Introduction
Palliative radiotherapy (PRT) during the last month of life (PRT30) should be avoided because relevant
clinical benefits are unlikely to occur. While traditional short-course fractionation regimens are suitable for
most patients, a minority may derive gains from higher doses of PRT. Compared to older regimens such as 13
fractions of 3 Gy, more hypofractionated, non-ablative concepts with reduced overall treatment time are not
well studied.<p>
<p>Methods
Retrospective analysis (2017-2020) of 107 patients treated to metastatic lesions (one or two target volumes
per patient) with traditional >2 weeks regimens or newer ≤2 weeks regimens, e.g. seven fractions of 5 Gy or
five fractions of 6 Gy.
<p>Results
Failure to complete radiotherapy was registered in 8% of patients (traditional fractionation) and 1%,
respectively (p=0.12). Moderate rates of PRT30 were observed (11% and 6%, respectively, p=0.44). PRT30 was
more likely in patients irradiated for brain or lymph node metastases. Utilization of newer ≤2 weeks
regimens was highest in 2020, presumably as a result of the coronavirus disease 2019 (COVID-19) pandemic.
<p>Conclusion
The implementation of newer fractionation regimens for selected patients has resulted in acceptable rates of
non-completion and PRT30. Optimal selection criteria remain to be determined. Established, guidelineendorsed short-course regimens such as five fractions of 4 Gy and 8-Gy single fractions continue to
represent important PRT approaches. | en_US |
dc.identifier.citation | Nieder C, Haukland E C, Mannsåker B (January 25, 2022) Shortened Palliative Radiotherapy Results in a Lower Rate of Treatment During the Last
Month of Life . Cureus 14(1) | en_US |
dc.identifier.cristinID | FRIDAID 2107646 | |
dc.identifier.doi | 10.7759/cureus.21617 | |
dc.identifier.issn | 2168-8184 | |
dc.identifier.uri | https://hdl.handle.net/10037/28289 | |
dc.language.iso | eng | en_US |
dc.publisher | Springer Nature | en_US |
dc.relation.journal | Radiation Oncology | |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | Copyright 2022 The Author(s) | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | en_US |
dc.rights | Attribution 4.0 International (CC BY 4.0) | en_US |
dc.title | Shortened Palliative Radiotherapy Results in a Lower Rate of Treatment During the Last Month of Life | en_US |
dc.type.version | publishedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |