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dc.contributor.authorHagen, Amalie Nilsen
dc.contributor.authorAriansen, Inger Kristine Holtermann
dc.contributor.authorHanssen, Tove Aminda
dc.contributor.authorLappegård, Knut Tore
dc.contributor.authorEggen, Anne Elise
dc.contributor.authorLøchen, Maja-Lisa
dc.contributor.authorNjølstad, Inger
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorHopstock, Laila Arnesdatter
dc.date.accessioned2023-01-30T11:08:51Z
dc.date.available2023-01-30T11:08:51Z
dc.date.issued2022-09-22
dc.description.abstractAims To study change over 8 years in cardiovascular risk, achievement of national guideline-based treatment targets of lipids, blood pressure (BP) and smoking in primary prevention of cardiovascular disease (CVD), medication use, and characteristics associated with target achievement among individuals with high CVD risk in a general population.<p> <p>Methods and results We followed 2524 women and men aged 40–79 years with high risk of CVD attending the population-based Tromsø study in 2007–08 (Tromsø6) to their participation in the next survey in 2015–16 (Tromsø7). We used descriptive statistics and regression models to study change in CVD risk and medication use, and characteristics associated with treatment target achievement. In total, 71.4% reported use of BP- and/or lipid-lowering medication at second screening. Overall, CVD risk decreased during follow-up, with a larger decrease among medication users compared with non-users. Treatment target achievement was 31.0% for total cholesterol <5 mmol/L, 27.3% for LDL cholesterol <3 mmol/L, 43.4% for BP <140/90 (<135/85 if diabetes) mmHg, and 85.4% for non-smoking. A total of 9.8% reached all treatment targets combined. Baseline risk factor levels and current medication use had the strongest associations with treatment target achievement. <p>Conclusion We found an overall improvement in CVD risk factors among high-risk individuals over 8 years. However, guideline-based treatment target achievement was relatively low for all risk factors except smoking. Medication use was the strongest characteristic associated with achieving treatment targets. This study has demonstrated that primary prevention of CVD continues to remain a major challenge.en_US
dc.identifier.citationHagen A, Ariansen I, Hanssen TA, Lappegård KT, Eggen AE, Løchen M, Njølstad i, Wilsgaard T, Hopstock LA. Achievements of primary prevention targets in individuals with high risk of cardiovascular disease: an 8-year follow-up of the Tromsø study. European Heart Journal Open (EHJ Open). 2022;2(5)en_US
dc.identifier.cristinIDFRIDAID 2116788
dc.identifier.doi10.1093/ehjopen/oeac061
dc.identifier.issn2752-4191
dc.identifier.urihttps://hdl.handle.net/10037/28414
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofHagen, A.N. (2023). Cardiovascular disease: risk assessment, total risk, and primary prevention in the general population. Insights from the Tromsø Study. (Doctoral thesis). <a href=https://hdl.handle.net/10037/28493>https://hdl.handle.net/10037/28493</a>.
dc.relation.journalEuropean Heart Journal Open (EHJ Open)
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0en_US
dc.rightsAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)en_US
dc.titleAchievements of primary prevention targets in individuals with high risk of cardiovascular disease: an 8-year follow-up of the Tromsø studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
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