English
norskLiver regeneration : the impact of altered portal hemodynamics on gene expression and growth of the porcine liver
Permanent link
https://hdl.handle.net/10037/2893
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Mortensen KE, Revhaug A.: 'Liver regeneration in surgical animal models – a historical perspective and clinical implications' (manuscript, reprinted with permission). Published version: European Surgical Research 2011;46:1-18, available at http://dx.doi.org/10.1159/000321361 (PDF)
Mortensen KE, Conley LN, Nygaard I, Sorenesen P, Mortensen E, Bendixen C, Revhaug A.: 'Increased sinusoidal flow is not the primary stimulus to liver regeneration', Comparative Hepatology 2010 Jan 20; 9:2, published Open Access with CC-license. (PDF)
Thesis introduction (PDF)
Date
2010-12-10Type
Doctoral thesisDoktorgradsavhandling
Abstract
Previous research on liver regeneration has focused on the volume and composition of the blood perfusing the liver remnant and their relative importance in initiating the cascade of liver regeneration after partial hepatectomy. Newer studies around year 2000 indicated nitric oxide was of paramount importance due to the increased shear stress in liver sinusoids. On the basis of experimental liver surgery on pigs, this thesis suggests that it is the composition of the portal blood and not the flow itself which is the most important stimulus to initiate and uphold liver regeneration. The thesis also contains a paper outlining a historical review of liver regeneration research in mainly large animal models and a new statistical method to analyse real-time measurements of hemodynamic variables in time series.
Description
Papers number 1 and 2 of the thesis are not available in Munin due to publisher's restrictions:
1. Mortensen KE, Godtliebsen F, Revhaug A.: 'Scale-space analysis of time series in circulatory research', American journal of physiology. Heart and circulatory physiology 2006. Dec; 291(6): H3012-22 (American Physiological Society). Available at http://dx.doi.org/10.1152/ajpheart.00168.2006
2. Mortensen KE, Conley LN, Hedegaard J, Kalstad T, Sorensen P, Bendixen C, Revhaug A.: 'Regenerative response in the pig liver remnant varies with the degree of resection and rise in portal pressure', American journal of physiology. Gastrointestinal and liver physiology 2008 Mar; 294(3): G819-30 (American Physiological Society). Available at http://dx.doi.org/10.1152/ajpgi.00179.2007
1. Mortensen KE, Godtliebsen F, Revhaug A.: 'Scale-space analysis of time series in circulatory research', American journal of physiology. Heart and circulatory physiology 2006. Dec; 291(6): H3012-22 (American Physiological Society). Available at http://dx.doi.org/10.1152/ajpheart.00168.2006
2. Mortensen KE, Conley LN, Hedegaard J, Kalstad T, Sorensen P, Bendixen C, Revhaug A.: 'Regenerative response in the pig liver remnant varies with the degree of resection and rise in portal pressure', American journal of physiology. Gastrointestinal and liver physiology 2008 Mar; 294(3): G819-30 (American Physiological Society). Available at http://dx.doi.org/10.1152/ajpgi.00179.2007
Publisher
Universitetet i TromsøUniversity of Tromsø
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