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dc.contributor.advisorLund-Blix, Nicolai Andre
dc.contributor.authorØien, Marit Zachariassen
dc.date.accessioned2023-05-15T06:09:46Z
dc.date.available2023-05-15T06:09:46Z
dc.date.issued2022-05-15en
dc.description.abstractBackground and aim: Vitamin A have been shown to influence immunity, and animal studies have shown that maternal vitamin A intake could have immunomodulatory effects that may influence offspring type 1 diabetes (T1D) development. There are few human studies that have investigated the association between vitamin A consumption and T1D. This study aimed to examine the association between maternal vitamin A intake during pregnancy and the risk of childhood T1D in the Norwegian, Mother, Father and Child Cohort study (MoBa). Methods: This study includes 82,605 children born between 2000 and 2009. Children were followed to April 15, 2018. T1D diagnosis was obtained from the Norwegian Childhood Diabetes Registry (NCDR). Maternal vitamin A intake was estimated through a semi-quantitative food frequency questionnaire (FFQ) and divided into quintiles and as well as modeled as a continuous exposure measure (per 100 retinol equivalents, RE/day). Hazard ratios (HR) were estimated using Cox proportional hazard regression, with adjustment for the maternal factors: T1D, pre-pregnant body mass index, smoking, vitamin D intake, education level, and age at delivery. Further analysis was performed to examine if vitamin A from supplements and food sources separately, as well as vitamin A intake below or above the Nordic Nutrition Recommendations (NNRs), was associated with risk of offspring T1D. Results: During a mean follow-up time of 12.2 years, 345 children developed T1D. The mean intake was 1,665 RE/day. Compared to the mid-quantile, the lowest fifth of total vitamin A intake (HR=1.17, 95% Cl: 0.83, 1.67) and highest fifth (HR=1.11, 95% Cl: 0.78, 1.59) was not statistically significant associated with the risk of offspring T1D. Total vitamin A was not log-linearly associated with T1D (HR per 100 RE/day: 1.00, 95% Cl: 0.99, 1.01). Intake below (HR=1.17, 95% Cl: 0.84, 1.62) or above (HR=1.11, 95% Cl: 0.73, 1.68) the NNRs daily recommended intake (DRI) was not associated with offspring T1D. Conclusion: Results in this large prospective cohort suggests no overall association between vitamin A consumption in pregnancy and the risk of offspring T1D.en_US
dc.identifier.urihttps://hdl.handle.net/10037/29204
dc.language.isoengen_US
dc.publisherUiT Norges arktiske universitetno
dc.publisherUiT The Arctic University of Norwayen
dc.rights.holderCopyright 2022 The Author(s)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0en_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)en_US
dc.subject.courseIDERN-3900
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Ernæring: 811en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Nutrition: 811en_US
dc.subjectvitamin Aen_US
dc.subjectretinoidsen_US
dc.subjectretinolen_US
dc.subjectbeta-caroteneen_US
dc.subjectMoBaen_US
dc.subjectpregnancy cohorten_US
dc.subjecttype 1 diabetesen_US
dc.subjectinsulin dependenten_US
dc.subjectautoimmuneen_US
dc.titleVitamin A consumption in pregnancy and risk of offspring type 1 diabetesen_US
dc.typeMastergradsoppgaveno
dc.typeMaster thesisen


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Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
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