Considerations on brain age predictions from repeatedly sampled data across time
Permanent link
https://hdl.handle.net/10037/30870Date
2023-08-16Type
Journal articleTidsskriftartikkel
Peer reviewed
Author
Korbmacher, Max; Wang, Mengyun; Eikeland, Rune; Buchert, Ralph; Andreassen, Ole; Espeseth, Thomas; Leonardsen, Esten Høyland; Westlye, Lars Tjelta; Maximov, Ivan; Specht, KarstenAbstract
Methods - We used densely sampled T1-weighted MRI data from four individuals (from two densely sampled datasets) to observe how brain age corresponds to age and is influenced by acquisition and quality parameters. For validation, we used two cross-sectional datasets. Brain age was predicted by a pretrained deep learning model.
Results - We found small within-subject correlations between age and brain age. We also found evidence for the influence of field strength on brain age which replicated in the cross-sectional validation data and inconclusive effects of scan quality.
Conclusion - The absence of maturation effects for the age range in the presented sample, brain age model bias (including training age distribution and field strength), and model error are potential reasons for small relationships between age and brain age in densely sampled longitudinal data. Clinical applications of brain age models should consider of the possibility of apparent biases caused by variation in the data acquisition process.