Signals of Death - Post-Diagnostic Single Gene Expression Trajectories in Breast Cancer - A Proof of Concept

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https://hdl.handle.net/10037/31235
DOI
https://doi.org/10.18261/9788215041193-2020-09
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Date
2020-12-08
Type
Chapter
Bokkapittel

Author
Lund, Eiliv; Holden, Marit; Thalabard, Jean-Christophe; Rasmussen Busund, Lill-Tove; Snapkov, Igor; Holden, Lars
Abstract
Using the time-dependent dynamics of gene expression from immune cells in blood, we aimed to explore single gene expression trajectories as biomarkers for death after a diagnosis of breast cancer introducing a new statistical method denoted Difference in Time Development Statistics (DTDS). This shows as proof of principle that the gene expression profiles from immune cells in blood differed in the postdiagnostic period are dependent on later vital status.
Publisher
Universitetsforlaget
Citation
Lund e, Holden M, Thalabard J, Rasmussen Busund LTRB, Snapkov IS, Holden L: Signals of Death - Post-Diagnostic Single Gene Expression Trajectories in Breast Cancer - A Proof of Concept. In: Lund e. Advancing Systems Epidemiology in Cancer - Exploring Trajectories of Gene Expression, 2020. Universitetsforlaget p. 141-162
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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)