dc.contributor.author | Seternes, Tore | |
dc.contributor.author | Poppe, Trygve T | |
dc.contributor.author | Bøgwald, Jarl | |
dc.contributor.author | Lynghammar, Arve | |
dc.contributor.author | Dalmo, Roy Ambli | |
dc.date.accessioned | 2023-12-20T12:09:14Z | |
dc.date.available | 2023-12-20T12:09:14Z | |
dc.date.issued | 2023-11-28 | |
dc.description.abstract | The scavenger endothelial cells (SECs) of vertebrates are an important class of endocytic cells responsible for
clearance of foreign and physiological waste macromolecules, partitioning in the immune system, functioning as
a cellular powerplant by producing high energy metabolites like lactate and acetate. All animal phyla possess
SECs, but the tissue localization of SECs has only been investigated in a limited number of species. By using a
specific ligand for scavenger receptors (formalin treated bovine serum albumin), the study revealed that in all
tetrapod species (amphibia, reptiles, birds and mammals) the SECs were found lining the sinusoids of the liver.
No SECs were found in the liver of any of the bony fishes (Osteichthyes) investigated. Interestingly, we found the
SECs not only to be located in the heart of marine species but also in some freshwater species such as Lota lota,
Percichthys trucha and Perca fluviatilis. In some fish species, the SECs were found both in the heart and/or kidney
in a number of marine and freshwater fishes, whereas in some marine, diadromous and freshwater fishes the
SECs were confined only to the kidney tissue. However, from these results it can be suggested that there is neither
a clear phylogenetic trend when it came to anatomical localization of SECs nor any pattern in terms of habitat
(salinity preferences). | en_US |
dc.identifier.citation | Seternes, Poppe, Bøgwald, Lynghammar, Dalmo. Anatomical distribution of scavenger endothelial cells in bony fishes (Osteichthyes). Fish and Shellfish Immunology. 2023 | en_US |
dc.identifier.cristinID | FRIDAID 2213891 | |
dc.identifier.doi | 10.1016/j.fsi.2023.109250 | |
dc.identifier.issn | 1050-4648 | |
dc.identifier.issn | 1095-9947 | |
dc.identifier.uri | https://hdl.handle.net/10037/32176 | |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.journal | Fish and Shellfish Immunology | |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | Copyright 2023 The Author(s) | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | en_US |
dc.rights | Attribution 4.0 International (CC BY 4.0) | en_US |
dc.title | Anatomical distribution of scavenger endothelial cells in bony fishes (Osteichthyes) | en_US |
dc.type.version | publishedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |