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Inadequate nutritional care for malnourished patients in four university hospitals – The QuaNuT study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-30)Background & Aims: Adequate nutritional care to malnourished patients is described as a human right, and recommendations from nutritional care guidelines are legally binding in Norway. The primary objective of this study was to investigate nutritional care in malnourished hospitalized patients. We also wanted to describe the association between malnutrition and length of stay (LOS), readmission, ... -
Generative artificial intelligence to produce high-fidelity blastocyst-stage embryo images
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-10)STUDY QUESTION - Can generative artificial intelligence (AI) models produce high-fidelity images of human blastocysts?<p> <p>SUMMARY ANSWER - Generative AI models exhibit the capability to generate high-fidelity human blastocyst images, thereby providing substantial training datasets crucial for the development of robust AI models.<p> <p>WHAT IS KNOWN ALREADY - The integration of AI into IVF ... -
Randomized controlled trial of nasogastric tube use after esophagectomy: Study protocol for the kinetic trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-16)Esophagectomy is a complex and complication laden procedure. Despite centralization, variations in perioparative strategies reflect a paucity of evidence regarding optimal routines. The use of nasogastric (NG) tubes post esophagectomy is typically associated with significant discomfort for the patients. We hypothesize that immediate postoperative removal of the NG tube is non-inferior to current ... -
Novel loss-of-function variants expand ABCC9-related intellectual disability and myopathy syndrome
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-13)Loss-of-function mutation of ABCC9, the gene encoding the SUR2 subunit of ATP sensitive-potassium (KATP) channels, was recently associated with autosomal recessive ABCC9-related intellectual disability and myopathy syndrome (AIMS). Here we identify nine additional subjects, from seven unrelated families, harbouring different homozygous loss-of-function variants in ABCC9 and presenting with a conserved ... -
Needs for community-based rehabilitation services and support 12 months after moderate and severe physical traumatic injuries: a brief report
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08)Patients with physical traumatic injuries frequently require long-term rehabilitation services. To strengthen rehabilitation services in the postacute phase, we need to assess characteristics of this population and their healthcare and rehabilitation needs in the community. This brief report summarizes the frequency of unmet rehabilitation needs in community-based rehabilitation during the first ... -
The outcomes of team-based learning versus small group interactive learning in the obstetrics and gynecology course for undergraduate students
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-17)Introduction - Team-based learning (TBL) is a well-established active teaching method which has been shown to have pedagogical advantages in some areas such as business education and preclinical disciplines in undergraduate medical education. Increasingly, it has been adapted to clinical disciplines. However, its superiority over conventional learning methods used in clinical years of medical school ... -
Joint effect of ischemic stroke and obesity on the risk of venous thromboembolism: the Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-27)Background: Patients with ischemic stroke have increased risk of venous thromboembolism (VTE). Obesity is prevalent in stroke patients and a well-established risk factor for VTE. Whether obesity further increases the VTE risk in patients with stroke remains unclear.<p> <p>Objectives: We investigated the joint effect of ischemic stroke and obesity on the risk of incident VTE in a population-based ... -
Major depression mistaken as frontotemporal dementia due to PET scan
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-02)Frontotemporal dementia (FTD) is associated with progressive degeneration of the frontal lobes and this leads to changes in language, motor symptoms, behavior and executive functions.1 In an early stage, patients with FTD usually have intact memory functions.2 40% of the cases of FTD are misdiagnosed,3 with delayed diagnosis compared to other dementias.4 Differentiating FTD from other psychiatric ... -
Appetite and dietary intake endpoints in cancer cachexia clinical trials: Systematic Review 2 of the cachexia endpoints series
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-11)There is no consensus on the optimal endpoint(s) in cancer cachexia trials. Endpoint variation is an obstacle when compar ing interventions and their clinical value. The aim of this systematic review was to summarize and evaluate endpoints used to assess appetite and dietary intake in cancer cachexia clinical trials. A search for studies published from 1 January 1990 until 2 June 2021 was conducted ... -
Exploring the dynamics of situational interest in team-based learning in undergraduate medical education
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-07-30)Background Team-based learning (TBL) is a widely recognized instructional approach in medical education blending direct instruction with active-cooperative learning in small groups. While TBL is known to enhance knowledge acquisition, its impact on student motivation, particularly through situational interest, remains underexplored. This study aimed to investigate the development of situational ... -
Cutaneous nerve biopsy in patients with symptoms of small fiber neuropathy: a retrospective study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-22)Objectives - We aimed to investigate to what extent small fiber tests were abnormal in an unselected retrospective patient material with symptoms suggesting that small fiber neuropathy (SFN) could be present, and to evaluate possible gender differences.<p> <p>Methods - Nerve conduction studies (NCS), skin biopsy for determination of intraepidermal nerve fiber density (IENFD) and quantitative ... -
Repeat expansions in AR, ATXN1, ATXN2 and HTT in Norwegian patients diagnosed with amyotrophic lateral sclerosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-14)Genetic repeat expansions cause neuronal degeneration in amyotrophic lateral sclerosis as well as other neurodegenerative disorders such as spinocerebellar ataxia, Huntington’s disease and Kennedy’s disease. Repeat expansions in the same gene can cause multiple clinical phenotypes. We aimed to characterize repeat expansions in a Norwegian amyotrophic lateral sclerosis cohort. Norwegian amyotrophic ... -
Age and healthy lifestyle behavior’s disparities and similarities on knowledge of myocardial infarction symptoms and risk factors among public and outpatients in a resource-limited setting, cross-sectional study in greater Gaborone, Botswana
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-04)Objectives In this cross-sectional study from Botswana, we investigated knowledge of myocardial infarction (MI) symptoms and risk factors among the general public and outpatients with MI risk factors based on age and lifestyle behaviors, in addition to assessing associations with sociodemographic and MI risk factors.<p> <p>Method Open-ended questionnaires about 8 MI symptoms and 10 risk factors, ... -
User satisfaction with child and adolescent mental health services: the association between user satisfaction and clinical outcomes
(Journal article; Tidsskriftartikkel, 2024-04-15)<p><i>Background - </i>This study aimed to examine the association between user satisfaction and clinical outcomes with child and adolescent mental health services (CAMHS) from the perspective of young people and their parents. The evidence bases for CAMHS user satisfaction measures are limited, with few studies investigating the link between user satisfaction and clinical outcomes. In particular, ... -
Brief Intervention as a Method to Reduce Z-Hypnotic Use by Older Adults: Feasibility Case Series
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-08)Background: Z-hypnotics or z-drugs are commonly prescribed for insomnia and sleep difficulties in older adults. These drugs are associated with adverse events and dependence and are not recommended for long-term use. Despite evidence of older adults being more sensitive to a wide array of adverse events and clinical guidelines advocating limiting use, inappropriate use in this population is still ... -
Cytokines in hepatitis C-infected patients with or without opioid maintenance therapy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-04)Objective: Both chronic hepatitis C virus (HCV) infection and opioids cause altered blood levels of cytokines. Previous studies have investigated levels of selected groups of cytokines in patients on opioid maintenance treatment. Little is known about the levels of multiple cytokines in patients with chronic HCV infection on opioid maintenance treatment. Our aim was to investigate the cytokine profile ... -
Metacognitive beliefs, mood symptoms, and fatigue four years after stroke: An explorative study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-25)Objective - This cross-sectional study investigated the relationship between metacognition and mood symptoms four years post-stroke and examined fatigue as a potential moderator for this relationship.<p> <p>Methods - A number of 143 participants completed a survey that included the Hospital Anxiety and Depression Scale (HADS), the Metacognition Questionnaire-30 (MCQ-30), the Fatigue Severity Scale ... -
Impact of physiotherapy access on health-related quality of life following hip fracture: an observational study on 30 752 hip fractures from the Norwegian Hip Fracture Register 2014–2018
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-06)Objectives - The main objective of this study was to investigate the characteristics of patients receiving private community physiotherapy (PT) the first year after a hip fracture. Second, to determine whether utilisation of PT could improve health-related quality of life (HRQoL).<p> <p>Methods - In an observational cohort study, 30 752 hip fractures from the Norwegian Hip Fracture Register were ... -
Challenges in Defining a Reference Set of Differentially Expressed lncRNAs in Ulcerative Colitis by Meta-Analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-05)The study aimed to identify common differentially expressed lncRNAs from manually curated ulcerative colitis (UC) gene expression omnibus (GEO) datasets. Nine UC transcriptomic datasets of clearly annotated human colonic biopsies were included in the study. The datasets were manually curated to select active UC samples and controls. R packages geneknitR, gprofiler, clusterProfiler were used for gene ... -
Real-time feedback on chest compression efficacy by hands-free carotid Doppler in a porcine model
(Journal article; Tidsskriftartikkel, 2024-02-20)Aim: Current guidelines for cardiopulmonary resuscitation (CPR) recommend a one-size-fits-all approach in relation to the positioning of chest compressions. We recently developed RescueDoppler, a hands-free Doppler ultrasound device for continuous monitoring of carotid blood flow velocity during CPR. The aim of the present study is to investigate whether RescueDoppler via real-time hemodynamic ...
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