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dc.contributor.authorSlettemeås, Jannice Schau
dc.contributor.authorSekse, Camilla
dc.contributor.authorSunde, Marianne
dc.contributor.authorNorström, Madelaine
dc.contributor.authorWester, Astrid Louise
dc.contributor.authorNaseer, Mohammed Umaer
dc.contributor.authorSimonsen, Gunnar Skov
dc.contributor.authorUlstad, Charlotte Rosenberg
dc.contributor.authorUrdahl, Anne Margrete
dc.contributor.authorLagesen, Karin
dc.date.accessioned2024-10-10T07:37:39Z
dc.date.available2024-10-10T07:37:39Z
dc.date.issued2024-07-06
dc.description.abstractBackground The usage of fluoroquinolones in Norwegian livestock production is very low, including in broiler production. Historically, quinolone-resistant Escherichia coli (QREC) isolated from Norwegian production animals rarely occur. However, with the introduction of a selective screening method for QREC in the Norwegian monitoring programme for antimicrobial resistance in the veterinary sector in 2014; 89.5% of broiler caecal samples and 70.7% of broiler meat samples were positive. This triggered the concern if there could be possible links between broiler and human reservoirs of QREC. We are addressing this by characterizing genomes of QREC from humans (healthy carriers and patients) and broiler isolates (meat and caecum). <p><p>Results The most frequent mechanism for quinolone resistance in both broiler and human E. coli isolates were mutations in the chromosomally located gyrA and parC genes, although plasmid mediated quinolone resistance (PMQR) was also identified. There was some relatedness of the isolates within human and broiler groups, but little between these two groups. Further, some overlap was seen for isolates with the same sequence type isolated from broiler and humans, but overall, the SNP distance was high. <p>Conclusion Based on data from this study, QREC from broiler makes a limited contribution to the incidence of QREC in humans in Norway.en_US
dc.identifier.citationSlettemeås JS, Sekse C, Sunde M, Norström M, Wester AL, Naseer MU, Simonsen GS, Ulstad CR, Urdahl AM, Lagesen K. Comparative genomics of quinolone-resistant Escherichia coli from broilers and humans in Norway. BMC Microbiology. 2024en_US
dc.identifier.cristinIDFRIDAID 2285865
dc.identifier.doi10.1186/s12866-024-03412-3
dc.identifier.issn1471-2180
dc.identifier.urihttps://hdl.handle.net/10037/35165
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.journalBMC Microbiology
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11227169/
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleComparative genomics of quinolone-resistant Escherichia coli from broilers and humans in Norwayen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)