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dc.contributor.authorWeli, Simon Chioma
dc.contributor.authorTryland, Morten
dc.date.accessioned2012-03-12T09:40:06Z
dc.date.available2012-03-12T09:40:06Z
dc.date.issued2011
dc.description.abstractAvipoxviruses (APVs) belong to the Chordopoxvirinae subfamily of the Poxviridae family. APVs are distributed worldwide and cause disease in domestic, pet and wild birds of many species. APVs are transmitted by aerosols and biting insects, particularly mosquitoes and arthropods and are usually named after the bird species from which they were originally isolated. The virus species Fowlpox virus (FWPV) causes disease in poultry and associated mortality is usually low, but in flocks under stress (other diseases, high production) mortality can reach up to 50%. APVs are also major players in viral vaccine vector development for diseases in human and veterinary medicine. Abortive infection in mammalian cells (no production of progeny viruses) and their ability to accommodate multiple gene inserts are some of the characteristics that make APVs promising vaccine vectors. Although abortive infection in mammalian cells conceivably represents a major vaccine bio-safety advantage, molecular mechanisms restricting APVs to certain hosts are not yet fully understood. This review summarizes the current knowledge relating to APVs, including classification, morphogenesis, host-virus interactions, diagnostics and disease, and also highlights the use of APVs as recombinant vaccine vectors.en
dc.identifier.citationVirology Journal (2011), 8:49en
dc.identifier.cristinIDFRIDAID 805208
dc.identifier.doidoi: 10.1186/1743-422X-8-49
dc.identifier.issn1743-422X
dc.identifier.urihttps://hdl.handle.net/10037/3922
dc.identifier.urnURN:NBN:no-uit_munin_3644
dc.language.isoengen
dc.publisherBioMed Centralen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical microbiology: 715en
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk mikrobiologi: 715en
dc.titleAvipoxviruses : infection biology and their use as vaccine vectorsen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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