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dc.contributor.authorLi, Fenglin
dc.contributor.authorZhang, Yiming
dc.contributor.authorZhong, Zhijian
dc.date.accessioned2012-03-12T14:03:22Z
dc.date.available2012-03-12T14:03:22Z
dc.date.issued2011
dc.description.abstractThe current study evaluated the glucose-lowering effect of ganoderma lucidum polysaccharides (Gl-PS) in streptozotocin (STZ)-induced diabetic mice. The diabetic mice were randomly divided into four groups (8 mice per group): diabetic control group, low-dose Gl-PS treated group (50 mg/kg, Gl-PS), high-dose Gl-PS treated group (150 mg/kg, Gl-PS) and positive drug control treated group (glibenclamide, 4 mg/kg), with normal mice used as the control group. Body weights, fasting blood glucose (FBG), serum insulin and blood lipid levels of mice were measured. After 28 days of treatment with Gl-PS, body weights and serum insulin levels of the Gl-PS treated groups was significantly higher than that of the diabetic control group , whereas FBG levels was significantly lower. Moreover, total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) levels of the Gl-PS treated groups had dropped, whereas the high density lipoprotein cholesterol (HDL-C) levels had increased. In addition, according to acute toxicity studies, Gl-PS did not cause behavioral changes and any death of mice. These data suggest that Gl-PS has an antihyperglycemic effect. Furthermore, considering the Gl-PS effects on lipid profile, it may be a potential hypolipidaemic agent, which will be a great advantage in treating diabetic conditions associated with atherosclerosis or hyperlipidemia.en
dc.identifier.citationInternational Journal of Molecular Sciences (2011), vol.12 nr. 9 s. 6135-6145en
dc.identifier.cristinIDFRIDAID 870304
dc.identifier.doidoi: 10.3390/ijms12096135
dc.identifier.issn1422-0067
dc.identifier.urihttps://hdl.handle.net/10037/3937
dc.identifier.urnURN:NBN:no-uit_munin_3659
dc.language.isoengen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Endocrinology: 774en
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774en
dc.titleAntihyperglycemic Effect of Ganoderma Lucidum Polysaccharides on Streptozotocin-Induced Diabetic Miceen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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