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    • Characterization of gut microbiota composition and functions in patients with chronic alcohol overconsumption 

      Bjørkhaug, Steinar Traae; Aanes, Håvard; Neupane, Sudan Prasad; Bramness, Jørgen Gustav; Malvik, Stine; Henriksen, Christine; Skar, Viggo Øystein; Medhus, Asle Wilhelm; Valeur, Jørgen (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-20)
      Excessive alcohol intake can alter the gut microbiota, which may underlie the pathophysiology of alcohol-related diseases. We examined gut microbiota composition and functions in patients with alcohol overconsumption for >10 years, compared to a control group of patients with a history of no or low alcohol intake. Faecal microbiota composition was assessed by 16S rRNA sequencing. Gut microbiota ...

    • Characterization of heavy users of skin care products among Norwegian women from 2003 to 2011 

      Aniansson, Boel Maria; Veierød, Marit Bragelien; Rylander, Charlotta; Lund, Eiliv; Sandanger, Torkjel M (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-16)
      Background: Several ingredients in personal care products (PCPs) have been classified as endocrine disruptors (EDs) and concern has been raised whether use of PCPs can affect human health. We aimed to characterize Norwegian female users of skin care products and compare life style characteristics between heavy users and non-users. <p>Methods: This cross-sectional study consisted of 114 202 women ...

    • Characterization of inhibition by vardenafil analogues of ATP-dependent transport of cGMP by the ABCC5 transporter. 

      Kuresh, Farzane (Master thesis; Mastergradsoppgave, 2015-05-27)
      Background: Clinical studies have reported overexpression of PDE5 and elevation of intracellular cyclic GMP in various types of cancer cells. ABCC5 transports intracellular cGMP out of the cells with high affinity, while PDE5 inhibitors prevent high affinity cGMP efflux by inhibiting ABCC5. Increasing intracellular cGMP levels through inhibition of PDE5 and PDE5 export activity is hypothesized ...

    • Characterization of Liposomes Using Quantitative Phase Microscopy (QPM) 

      Cauzzo, Jennifer; Jayakumar, Nikhil; Ahluwalia, Balpreet Singh; Ahmad, Azeem; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-21)
      The rapid development of nanomedicine and drug delivery systems calls for new and effective characterization techniques that can accurately characterize both the properties and the behavior of nanosystems. Standard methods such as dynamic light scattering (DLS) and fluorescent-based assays present challenges in terms of system’s instability, machine sensitivity, and loss of tracking ability, among ...

    • Characterization of mitochondrial mRNAs in codfish reveals unique features compared to mammals 

      Coucheron, Dag-Hugo; Nymark, Marianne; Breines, Ragna; Karlsen, Bård Ove; Andreassen, morten; Jørgensen, Tor Erik; Moum, Truls; Johansen, Steinar Daae (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Expression and processing of mitochondrial gene transcripts are fundamental to mitochondrial function, but information from early vertebrates like teleost fishes is essentially lacking. We have analyzed mitogenome sequences of ten codfishes (family Gadidae), and provide complete sequences from three new species (Saithe, Pollack and Blue whiting). Characterization of the mitochondrial mRNAs in Saithe ...

    • Characterization of Norwegian women eating wholegrain bread 

      Bakken, Toril; Braaten, Tonje; Olsen, Anja; Lund, Eiliv; Skeie, Guri (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-25)
      To investigate dietary and non-dietary characteristics of wholegrain bread eaters in the Norwegian Women and Cancer study.<br>Cross-sectional study using an FFQ.<br>Women were divided into two groups according to wholegrain bread consumption.<br>Adult women (n 69 471).<br>Median daily consumption of standardized slices of wholegrain bread was 2·5 in the low intake group and 4·5 in the high intake ...

    • Characterization of novel precursor miRNAs using next generation sequencing and prediction of miRNA targets in Atlantic halibut 

      Bizuayehu, Teshome; Fernandes, Jorge; Johansen, Steinar Daae; Babiak, Igor (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      microRNAs (miRNAs) are implicated in regulation of many cellular processes. miRNAs are processed to their mature functional form in a step-wise manner by multiple proteins and cofactors in the nucleus and cytoplasm. Many miRNAs are conserved across vertebrates. Mature miRNAs have recently been characterized in Atlantic halibut (Hippoglossus hippoglossus L.). The aim of this study was to identify and ...

    • Characterization of the Arabidopsis thaliana homologue of NBR1 

      Svenning, Steingrim (Master thesis; Mastergradsoppgave, 2009-05-15)
      It is now well established that p62 and NBR1 are selectively degraded by autophagy and can act as cargo receptors or adaptors for the autophagic degradation of ubiquitinated substrates. Research on autophagy in plants is also well under way, but the mechanism by which target substrates are sequestered for autophagic degradation has not been elucidated. The uncharacterized plant protein Q9SB64 shares ...

    • Characterization of the cell secretomes from undifferentiated and chondro-induced stem cells 

      Yonas Hambissa, Jerusalem (Master thesis; Mastergradsoppgave, 2015-05-20)
      Background: Articular cartilage is an essential part of the skeletal system. It provides a frictionless surface for smooth pain-free articulation and limits the load applied to subchondral bone during joint movement. Articular cartilage is an avascular and aneural tissue without lymphatic vessels. Due to this unique nature, articular cartilage has poor self-repair capacity. Therefore, minor cartilage ...

    • Characterization of the degree of food processing in the European Prospective Investigation into Cancer and Nutrition: Application of the Nova classification and validation using selected biomarkers of food processing 

      Huybrechts, Inge; Rauber, Fernanda; Nicolas, Geneviève; Casagrande, Corinne; Kliemann, Nathalie; Wedekind, Roland; Biessy, Carine; Scalbert, Augustin; Touvier, Mathilde; Aleksandrova, Krasimira; Jakszyn, Paula; Skeie, Guri; Bajracharya, Rashmita; Boer, Jolanda M. A.; Borné, Yan; Chajes, Veronique; Dahm, Christina C.; Dansero, Lucia; Guevara, Marcela; Heath, Alicia K.; Ibsen, Daniel B.; Papier, Keren; Katzke, Verena; Kyrø, Cecilie; Masala, Giovanna; Molina-Montes, Esther; Robinson, Oliver J. K.; Santiuste de Pablos, Carmen; Schulze, Matthias B.; Simeon, Vittorio; Sonestedt, Emily; Tjønneland, Anne; Tumino, Rosario; van der Schouw, Yvonne T.; Verschuren, W. M. Monique; Vozar, Beatrice; Winkvist, Anna; Gunter, Marc J.; Monteiro, Carlos A.; Millett, Christopher; Levy, Renata Bertazzi (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-16)
      Background: Epidemiological studies have demonstrated an association between the degree of food processing in our diet and the risk of various chronic diseases. Much of this evidence is based on the international Nova classification system, which classifies food into four groups based on the type of processing: (1) Unprocessed and minimally processed foods, (2) Processed culinary ingredients, ...

    • Characterization of the Ion Exchange Reaction Between Propranolol-H+ or K+ with Amberlite IRP 69 Resin by Both, Isothermal Titration Calorimetry and (Flame) Photometric Equilibrium Analysis 

      Wagner, Marita; Zeiss, Daniel Horst; Bauer-Brandl, Annette (Journal article; Tidsskriftartikkel; Peer reviewed, 2009)

    • Characterization of vasskveite (water halibut) syndrome for automated detection 

      Ortega, Samuel; Ofstad, Ragni; Syed, Shaheen; Kranz, Mathias; Heia, Karsten; Anderssen, Kathryn Elizabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-23)
      In recent years, cases of vasskveite (water halibut) syndrome in halibut have been increasing. At the moment, there exists no way to screen for the syndrome immediately after capture, which is problematic for both exporters and purchasers. In this article, we compared good quality halibut and halibut exhibiting the syndrome using a variety of techniques. Hyperspectral imaging was used to quantify ...

    • Charcot-Marie-Tooth disease (CMT): statistical analysis and revision of molecular genetic diagnostics in a patient population and identification of the disease locus in a large Norwegian family with CMT. 

      Østern, Rune André Helland (Doctoral thesis; Doktorgradsavhandling, 2014-09-19)
      CMT is a common inherited disease of the peripheral nerves that may be caused by mutations in multiple genes, most are rare. Our aim was to describe the spectrum of mutations and genes in Norwegian CMT patients, identify factors associated with diagnostic findings, revise the testprotocol, and evaluate the assessments of genetic variants of uncertain clinical significance. Furthermore, we searched ...

    • CHEK2 Mutations Affecting Kinase Activity Together With Mutations in TP53 Indicate a Functional Pathway Associated with Resistance to Epirubicin in Primary Breast Cancer 

      Chrisanthar, Ranjan; Knappskog, Stian; Løkkevik, Erik; Anker, Gun; Østenstad, Bjørn; Lundgren, Steinar; Berge, Elisabet O.; Risberg, Terje; Mjaaland, Ingvil; Mæhle, Lovise; Engebretsen, Lars Fredrik; Lillehaug, Johan Richard; Lønning, Per Eystein (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-08-26)
      Background Chemoresistance is the main obstacle to cure in most malignant diseases. Anthracyclines are among the main drugs used for breast cancer therapy and in many other malignant conditions. Single parameter analysis or global gene expression profiles have failed to identify mechanisms causing in vivo resistance to anthracyclines. While we previously found TP53 mutations in the L2/L3 domains to ...

    • Chemical and Enzyme-Assisted Extraction of Fucoidan from two Species of Brown Macroalgae (Ascophyllum nodosum and Saccharina latissima) 

      Maribu, Ingrid; Arnesen, Jan-Arne; Elvevold, Kjetil; Haug, Tor (Conference object; Konferansebidrag, 2022)
      Macroalgae are vital species and are known to produce a wide range of bioactive compounds including polysaccharides, such as fucoidan. Traditionally, these compounds are extracted using hazardous solvents that leads to environmental pollution and waste. Considering this, more sustainable technologies are being investigated as greener alternatives.<p> <p>The main goal of this study was to ...

    • The chemotherapeutic drug methotrexate selects for antibiotic resistance 

      Gudmundsdottir, Jonina; Fredheim, Elizabeth G. Aarag; Koumans, Catharina I.M.; Hegstad, Joachim; Tang, Po-Cheng; Andersson, Dan I.; Samuelsen, Ørjan; Johnsen, Pål Jarle (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-11)
      Background: Understanding drivers of antibiotic resistance evolution is fundamental for designing optimal treatment strategies and interventions to reduce the spread of antibiotic resistance. Various cytotoxic drugs used in cancer chemotherapy have antibacterial properties, but how bacterial populations are affected by these selective pressures is unknown. Here we test the hypothesis that the widely ...

    • Chemsex blant menn – en spørreundersøkelse 

      Haugstvedt, Åse; Amundsen, Eirik; Berg, Rigmor (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-03)
      <i>BAKGRUNN</i> - Formålet med undersøkelsen var å kartlegge forekomsten av rusmiddelbruk under sex (chemsex) blant et utvalg av mannlige pasienter ved Olafiaklinikken i Oslo, en poliklinikk for seksuelt overførbare infeksjoner. Vi ønsket også å se hvilke variabler innen psykisk helse, seksuelt overførbare infeksjoner og seksualatferd som var assosiert med chemsex for menn som har sex med menn og ...

    • Chertbruddet i Melsvik. Undersøkelse av chertbrudd, utvinningsteknologi og bosetningsspor fra tidlig eldre steinalder i Melsvik, Alta k., Finnmark f. 

      Niemi, Anja Roth; Cerbing, Mikael; Nergaard, Ragnhild Holten; Oppvang, Janne; Storemyr, Per (Research report; Forskningsrapport, 2019)
      I 2012-2013 ble et chertbrudd fra steinalderen undersøkt utenfor Alta i Finnmark. Undersøkelsen omfattet 1000 m2 av steinbruddet, og 3500 m2 av bosetingsområdene som lå like ved. I tillegg til utgravning ble det gjort eksperimenter med utvinning av chert i bruddet. Resultatene viser at bruddet ble brukt allerede 8400 f.Kr., og at fyrsetting var den viktigste metoden for å bryte chert fra berget. ...

    • Child maltreatment, psychopathological symptoms, and onset of diabetes mellitus, hypothyroidism and COPD in adulthood 

      Sheikh, Mashhood Ahmed (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-01)
      <p><I>Background</I>: The aim of this study was to assess the associations between child maltreatment (CM), psychopathological symptoms, and onset of diabetes mellitus, hypothyroidism (i.e., low metabolism), and chronic bronchitis/emphysema/COPD in adulthood.</p> <p><I>Methods</I>: The present analysis used cross-sectional data collected in 2007–2008 within the Tromsø Study, Norway (N = 12,981). ...

    • Child Mental Health in Nepal. An epidemiological study of emotional and behavioral problems (EBP) among Nepali schoolchildren reported by parents and teachers 

      Ma, Jasmine (Doctoral thesis; Doktorgradsavhandling, 2023-01-20)
      <p><i>Background -</i> There is a substantial gap in our knowledge about the prevalence, magnitude, and correlates of child emotional and behavioral problems (EBPs) in Nepal. Little is known about the agreement between parent and teacher reports on EBP among Nepali children. Therefore, a large-scale survey in the general population was undertaken to fill this gap. <p><i>Methods -</i> This is a ...