<p><i>Background - </i>Ageing of the general population, declining incidence of myocardial infarction (MI) and improvements in medical treatment have resulted in an increase in heart failure (HF) prevalence. At the same time, number of studies linked to all-cause mortality and HF, co-existing HF and chronic obstructive pulmonary disease (COPD) are scarce. <p><i>Objective - </i>To study long-term ...

Due to the large number of patients with severe coronavirus disease 2019 (COVID-19), many were treated outside the traditional walls of the intensive care unit (ICU), and in many cases, by personnel who were not trained in critical care. The clinical characteristics and the relative impact of caring for severe COVID-19 patients outside the ICU is unknown. This was a multinational, multicentre, ...

There are an increasing number of educational programs to improve clinical competence and skills to treat mental disorders. For complex disorders there is also a focus on improving the quality of interprofessional work. This paper reports on interprofessional outputs of an educational program on eating disorders. A total of 207 professionals who completed the program were requested to describe up ...

Great advances in molecular biology, genetics and imaging serve to enhance the desire to develop multi-level and multi-scale models for "personalized medicine" but they remain very challenging for high prevalence, high impact childhood onset neuropsychiatric disorders. We currently have the capacity to develop innovative, effective and efficient clinical decision support models, while also creating ...

<i>Background</i> - Randomised trials on antibiotic treatment for patients with chronic low back pain and vertebral endplate changes visible on MRI (Modic changes) have shown mixed results. A possible explanation might be a real treatment effect in subgroups of the study populations. The purpose of the present study was to explore potential clinical effect modifiers of 3-months oral amoxicillin ...

<i>Introduction</i> - Diarrhea-predominant irritable bowel syndrome (IBS-D) is a gastrointestinal disease with a high incidence and no effective drugs available. Compound Glutamine Entersoluble Capsules (CGEC) is a compound preparation integrating Sijunzi Decoction and L-Glutamine. The aim of this systematic review was to evaluate the clinical effects and safety of CGEC for IBS-D.<p> <p><i>Methods</i> ...

Systemisk Lupus Erythematosus (SLE) er en kronisk sykdom der immunforsvaret produserer antistoffer som kan angripe kroppens egne organer. I 1997 ble klassifikasjonskriteriene for å stille diagnosen endret slik at flere typer autoantistoffer ble inkludert. For å undersøke mulige endringer etter innføring av de nye 1997 klassifikasjonskriteriene for SLE, delte vi inn pasientene i to grupper. En ...

Introduction: Identifying predictors of bacterial and viral pathogens in sputum from patients with acute exacerbations of chronic obstructive pulmonary disease (COPD) may help direct management.<p> <p>Methods: We used data from a trial evaluating a C-reactive protein (CRP) point of care guided approach to managing COPD exacerbations in primary care. We used regression analyses to identify ...

Object - Although many patients report clinical improvement after surgery due to degenerative cervical myelopathy, the aim of intervention is to stop progression of spinal cord dysfunction. We wanted to provide estimates and assess achievement rates of Minimal Clinically Important Difference (MCID) at 3- and 12-month follow-up for Neck Disability Index (NDI), Numeric Rating Scale for arm pain (NRS-AP) ...

Vitamin D is vital for calcium homeostasis and skeletal health, has immunomodulatory effects and is involved in the regulation of differentiation and proliferation of many different cell types. Adipose tissue is an important metabolic organ and a major organ for vitamin D storage. Though, the role of vitamin D and its function in adipose tissue is not fully explored. This thesis applies a solvent ...