Introduction - Breast cancer is the most common cancer worldwide and the leading cause of cancer related deaths among women. The high incidence and mortality of breast cancer calls for improved prevention, diagnostics, and treatment, including identification of new prognostic and predictive biomarkers for use in precision medicine.<p> <p>Material and methods - With the aim of compiling a cohort ...

The Tromsø Study was initiated in 1974 in an attempt to help combat the high mortality of cardiovascular diseases in Norway, that was particularly pronounced among middle-aged men. In the mid-1970s, Norwegian men had a 20% risk of dying of myocardial infarction (MI) before the age of 75 years. The situation in Northern Norway was even worse.1 The primary aim of the Tromsø Study was to determine ...

The main objective of this thesis was to examine the importance of interprofessional collaboration and teamwork between different health care professionals on outcomes that are relevant for the professionals themselves but also for the organizations, and indirectly also for the users of the different services. Interprofessional collaboration and teamwork are an integral part of the work health and ...

<i>Background</i>: Autologous matrix-induced chondrogenesis (AMIC) is a single-stage alternative to autologous chondrocyte implantation for treatment of localized cartilage defects of the knee. To our knowledge, no randomized controlled trial exists comparing the 2 methods.<p><p> <i>Purpose</i>: To evaluate any difference in the outcome of AMIC as compared with collagen-covered autologous chondrocyte ...

The continuous increase in resistance development towards antimicrobial agents is a well-known problem, however, insecurities exist about how frequently the emergence of resistance in microbes, at the same time, leads to an increased sensitivity to other antimicrobial agents. This phenomenon is called “collateral sensitivity”. We evolved resistance in clinical E. coli strains towards three antimicrobial ...

The increase in antimicrobial resistance in bacteria is a serious problem in public heath limiting the efficacy of available antimicrobials for treatment of infections. E. coli is the most frequent cause of uncomplicated urinary tract infections. Ciprofloxacin is an important antimicrobial for treatment of uncomplicated urinary tract infections. Unfortunately, resistance to ciprofloxacin is commonly ...

The escalating emergence of AMR is a growing public health concern, and a result of the use and misuse of antibiotics since its introduction. To prevent the development of resistance and preserve the efficacy of antimicrobial agents, new treatment strategies is of utmost importance. One possible approach may be to take advantage of collateral sensitivity, a phenomenon where bacteria acquiring ...

<p><i>Objective</i>: Many researchers view retrospective reports with skepticism. Indeed, the observed association between retrospectively-reported childhood disadvantage (CD) and morbidity in adulthood has been criticized as an artefactual correlation driven by the psychological state of the respondent at the time of reporting (current psychological state). The aim of this study was to assess the ...

PURPOSE:To evaluate the influence of coma on manifest refractive cylinder (MRC) in eyes with coma-dominated corneal optics and suggest alternative guidelines for surgical planning of astigmatism correction in topography-guided ablation and toric intraocular lens (IOL) exchange surgery.<p> <p>METHODS:Twelve eyes with coma-dominant corneal optics and low lenticular astigmatism were selected. The ...

Background - Shoulder arthroplasty is associated with significant post-operative pain. Interscalene plexus block is the gold standard for pain management in patients undergoing this surgery, however, alternatives are currently being developed. We hypothesized that a combination of anterior suprascapular nerve block and lateral sagittal infraclavicular block would provide effective post-operative ...