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    • Cutoff criteria for the placebo response: a cluster and machine learning analysis of placebo analgesia. 

      Aslaksen, Per M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-28)
      Computations of placebo effects are essential in randomized controlled trials (RCTs) for separating the specific effects of treatments from unspecific effects associated with the therapeutic intervention. Thus, the identification of placebo responders is important for testing the efficacy of treatments and drugs. The present study uses data from an experimental study on placebo analgesia to suggest ...

    • Cyanobacterial ribosomal RNA genes with multiple, endonuclease-encoding group I introns 

      Bhattacharya, Debashish; Haugen, Peik; Palmer, Jeffrey D.; Turner, Seán; Lewis, Louise A.; Pryer, Kathleen M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2007-09-08)
      Background: Group I introns are one of the four major classes of introns as defined by their distinct splicing mechanisms. Because they catalyze their own removal from precursor transcripts, group I introns are referred to as autocatalytic introns. Group I introns are common in fungal and protist nuclear ribosomal RNA genes and in organellar genomes. In contrast, they are rare in all other ...

    • Cyberbullying status and mental health in Norwegian adolescents 

      Kaiser, Sabine; Kyrrestad, Henriette; Fossum, Sturla (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-26)
      The aim of the present study was to examine how the cyberbullying status (not involved, cyber‐victim only, cyberbully only, cyber‐victim and bully) is related to the mental health of the adolescents when controlled for traditional bullying experience. We also examined the potential moderator sex on the relationship between cyberbullying status and mental health. Univariate analyses of variance were ...

    • Cyclic nucleotide dependent ATPase activity in inside out vesicles from human erythrocytes 

      Rafiq, Sarah (Master thesis; Mastergradsoppgave, 2015-01-27)
      The transport of cyclic nucleotides out of the cell is energy requiring, dependent on ATP- hydrolysis. The ability to stimulate this ATPase is a hallmark of substrates for ABC-transporters e.g. ABCC5, ABCC4. It is believed that ABCC5 transporter has selective high affinity for cGMP. Previous studies support the idea that ABCC5 contribute to cGMP transport by human erythrocytes. Human erythrocyte ...

    • Cyclooxygenase-2 blockade can improve efficacy of VEGF-targeting drugs 

      Ben-Batalla, Isabel; Cubas-Cordova, Miguel; Udonta, Florian; Wroblewski, Mark; Waizenegger, Jonas S.; Janning, Melanie; Sawall, Stefanie; Gensch, Victoria; Zhao, Lin; Martinez, Inigo Zubiavrre; Riecken, Kristoffer; Fehse, Boris; Pantel, Klaus; Bokemeyer, Carsten; Loges, Sonja (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-31)
      Anti-angiogenic therapies were approved for different cancers. However, significant primary and secondary resistance hampers efficacy in several tumor types including breast cancer. Thus, we need to develop clinically applicable strategies to enhance efficacy of anti-angiogenic drugs. We report that anti-angiogenic therapies can induce upregulation of cyclooxygenase-2 (Cox-2) and of its product ...

    • Cyclophosphamide effect on immunoglobulins levels in AAV patients treated with long-term pre-emptive rituximab maintenance. 

      Besada, Emilio; Koldingsnes, Wenche; Nossent, Johannes C (Conference object; Konferansebidrag, 2013)

    • Cystatin C and cardiovascular disease: a Mendelian randomization study 

      van der Laan, Sander W; Fall, Tove; Sourmare, Aicha; Teumer, Alexander; Sedaghat, Sanaz; Baumert, Jens; Zahaneh, Delilah; van Setten, Jessica; Isgum, Ivana; Galesloot, Tessel E.; Arpegård, Johannes; Amouyel, Philippe; Trompet, Stella; Waldenberger, Melanie; Dörr, Marcus; Magnusson, Patrik K.; Giedraitis, Vilmantas; Larsson, Anders; Morris, Andrew P.; Felix, Janine F.; Morrison, Alanna C.; Franceschini, Nora; Bis, Joshua C.; Kavousi, Maryam; O'Donnell, Christopher J.; Drenos, Fotios; Tragante, Vinicius; Munroe, Patricia B.; Malik, Rainer; Dichgans, Martin; Worrall, Bradford B.; Erdmann, Jeanette; Nelson, Christopher P.; Samani, Nilesh J.; Schunkert, Heribert; Marchini, Jonathan; Patel, Riyaz S.; Hingorani, Aroon D.; Lind, Lars; Pedersen, Nancy L.; de Graaf, Jacqueline; Kiemeney, Lambertus A.L.M.; Baumeister, Sebastian E.; Franco, Oscar H.; Hofman, Albert; Uitterlinden, André G.; Koenig, Wolfgang; Meisinger, Christa; Peters, Annette; Thorand, Barbara; Jukema, J.Wouter; Eriksen, Bjørn Odvar; Toft, Ingrid; Wilsgaard, Tom; Onland-Moret, N. Charlotte; van der Schouw, Yvonne T.; Debette, Stéphanie; Kumari, Meena; Svensson, Per; van der Harst, Pim; Kivimäki, Mika; Keating, Brendan J.; Sattar, Naveed; Dehghan, Abbas; Reiner, Alex P.; Ingelsson, Erik; Den Ruijter, Hester M.; de Bakker, Paul I.W.; Pasterkamp, Gerard; Ärnlöv, Johan; Holmes, Michael V.; Asselbergs, Folkert W. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-30)
      BACKGROUND<br> Epidemiological studies show that high circulating cystatin C is associated with risk of cardiovascular disease (CVD), independent of creatinine-based renal function measurements. It is unclear whether this relationship is causal, arises from residual confounding, and/or is a consequence of reverse causation.<br> OBJECTIVES<br>The aim of this study was to use Mendelian randomization ...

    • Cystatin C is associated with risk of venous thromboembolism in subjects with normal kidney function - the Tromso study 

      Brodin, Ellen Elisabeth; Brækkan, Sigrid Kufaas; Vik, Anders; Brox, Jan; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Background Previous studies have shown an association between impaired kidney function, assessed by cystatin C-based estimated glomerular filtration rate, and venous thromboembolism. The aim of this study was to investigate whether serum cystatin C was associated with a risk of venous thromboembolism among subjects with normal kidney function in a prospective population-based study. Design and ...

    • Cystatin C-Based Equation to Estimate GFR without the Inclusion of Race and Sex 

      Pottel, Hans; Björk, Jonas; Rule, Andrew D.; Ebert, Natalie; Eriksen, Bjørn Odvar; Dubourg, Laurence; Vidal-Petiot, Emmanuelle; Grubb, Anders; Hansson, Magnus; Lamb, Edmund J.; Littmann, Karin; Mariat, Christophe; Melsom, Toralf; Schaeffner, Elke; Sundin, Per-Ola; Åkesson, Anna; Larsson, Anders; Cavalier, Etienne; Bukabau, Justine B.; Sumaili, Ernest K.; Yayo, Eric; Monnet, Dagui; Flamant, Martin; Nyman, Ulf; Delanaye, Pierre (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-26)
      BACKGROUND - The accuracy of estimation of kidney function with the use of routine metabolic tests, such as measurement of the serum creatinine level, has been controversial. The European Kidney Function Consortium (EKFC) developed a creatinine-based equation (EKFC eGFRcr) to estimate the glomerular filtration rate (GFR) with a rescaled serum creatinine level (i.e., the serum creatinine level is ...

    • Cytokine concentrations are related to level of mental distress in inpatients not using anti-inflammatory drugs 

      Toft, Helge Prytz; Lien, Lars; Neupane, Sudan Prasad; Abebe, Dawit Shawel; Tilden, Terje; Wampold, Bruce E.; Bramness, Jørgen G. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-02)
      <p><i>Objective - </i>Cross-sectional data show elevated levels of circulating cytokines in psychiatric patients. The literature is divided concerning anti-inflammatory drugs’ ability to relieve symptoms, questioning a causal link between inflammatory pathways and psychiatric conditions. We hypothesised that the development of circulating cytokine levels is related to mental distress, and that this ...

    • Cytokine network in adults with falciparum malaria and HIV-1: increased IL-8 and IP-10 levels are associated with disease severity 

      Berg, Åse; Patel, Sam; Gonca, Miguel; Catarina, David; Otterdal, Kari; Ueland, Thor; Dalen, Ingvild; Kvaløy, Jan Terje; Mollnes, Tom Eirik; Aukrust, Pål; Langeland, Nina (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Cytokine profiles and diagnoses in elderly, hospitalised psychiatric patients 

      Bugge, Erlend; Wynn, Rolf; Mollnes, Tom Eirik; Reitan, Solveig Merete Klæbo; Grønli, Ole Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-27)
      <p><i>Background:</i> There is a paucity of studies on inflammatory markers in elderly psychiatric patients. Hence, our study was undertaken to investigate cytokines as biomarkers in diagnostically unselected elderly patients admitted to a psychiatric hospital. <p><i>Methods:</i> Demographic data, clinical data and blood samples, including 27 cytokines, were collected from 98 patients above 60 ...

    • Cytokine profiling and post-transfusion haemoglobin increment in patients with haematological diseases 

      Wendelbo, Øystein; Opheim, Elin Netland; Hervig, Tor; Lunde, Turid Helen Felli; Bruserud, Øystein; Mollnes, Tom Eirik; Reikvam, Håkon (Journal article; Tidsskriftartikkel, 2018-08-29)
      <p><i>Background and Objectives</i>: In a previous pilot study, we demonstrated significantly lower haemoglobin (Hb) increment after red‐blood‐cell (RBC) transfusions in febrile patients compared to patients without fever. The aim of this study was to examine associations between inflammatory mediators and post‐transfusion haemoglobin increment in patients with haematological diseases.</p> <p>< ...

    • Cytokine responses, microbial aetiology and short-term outcome in community-acquired pneumonia 

      Siljan, William Ward; Holter, Jan Cato; Nymo, Ståle Haugset; Husebye, Einar; Ueland, Thor; Aukrust, Pål; Mollnes, Tom Eirik; Heggelund, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-24)
      Background:<br> The inflammatory response to community-acquired pneumonia (CAP) is orchestrated through activation of cytokine networks and the complement system. We examined the association of multiple cytokines and the terminal complement complex (TCC) with microbial aetiology, disease severity and shortterm outcome.<br> Materials and methods: <br>Plasma levels of 27 cytokines and TCC were ...

    • Cytologi av spyttkjertler. En kvalitetssikringsstudie 

      Ellefsrud, Fredrik (Master thesis; Mastergradsoppgave, 2015-06-01)
      Bakgrunn: Punksjonscytologi er et viktig ledd i diagnostikken av tumor i spyttkjertler. Flere studier har blitt gjort på testegenskaper, og diagnostisk sensitivitet for cytologi av maligne tumorer er blitt beskrevet mellom 55-88%. Vi ønsket med denne oppgaven å undersøke diagnostisk sensitivitet for punksjonscytologi av spyttkjerteltumorer utført ved Universitetssykehuset i Nord-Norge. Materiale ...

    • The cytolytic amphipathic β(2,2)-amino acid LTX-401 induces DAMP release in melanoma cells and causes complete regression of B16 melanoma 

      Eike, Liv-Marie; Mauseth, Brynjar; Camilio, Ketil Andre; Rekdal, Øystein; Sveinbjørnsson, Baldur (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      In the present study we examined the ability of the amino acid derivative LTX-401 to induce cell death in cancer cell lines, as well as the capacity to induce regression in a murine melanoma model. Mode of action studies in vitro revealed lytic cell death and release of danger-associated molecular pattern molecules, preceded by massive cytoplasmic vacuolization and compromised lysosomes in treated ...

    • Cytomegalovirus infection and dexamethasone effects in liver sinusoidal endothelial cells 

      Kyrrestad, Ingelin (Doctoral thesis; Doktorgradsavhandling, 2024-03-15)
      The liver is a major organ in the body's defense against blood-borne pathogens. It acts as a filter for the blood and is a central site for immune responses, and a central hub for various metabolic processes. Within the liver, an extensive network of small blood vessels, the hepatic sinusoids, are key sites for the exchange of nutrients and waste products between the blood circulation and the liver ...

    • Cytomegalovirus-SpecificImmunoglobulin G is associated with chronic lung disease in children and adolescents from sub-Saharan Africa with perinatal HIV infection 

      Bowen, Dan Hameiri; Sovershaeva, Evgeniya; Charlton, Bethany; Schive, Cecilie; Odland, Jon Øyvind; McHugh, Grace; Bandason, Tsitsi; Mayin, Justin; Ferrand, Rashida A.; Yindom, Louis-Marie; Rowland-Jones, Sara L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-26)
      In a cross-sectional study of 296 children and adolescents from Zimbabwe living with perinatal human immunodeficiency virus, individuals with the top tertile of cytomegalovirus-specific immunoglobulin G titer had an increased odds of chronic lung disease (odds ratio, 3.33; 95% confidence interval, 1.37–8.85; P = .010).

    • Cytoplasmic BRMS1 expression in malignant melanoma is associated with increased disease-free survival 

      Slipicevic, Ana; Holm, Ruth; Emilsen, Elisabeth; Rosnes, Anne Katrine Ree; Welch, Danny R.; Mælandsmo, Gunhild; Flørenes, Vivi Ann (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Breast cancer metastasis suppressor 1 (BRMS1) blocks metastasis in melanoma xenografts; however, its usefulness as a biomarker in human melanomas has not been widely studied. The goal was to measure BRMS1 expression in benign nevi, primary and metastatic melanomas and evaluate its impact on disease progression and prognosis. Paraffin-embedded tissue from 155 primary melanomas, 69 metastases and 15 ...

    • Cøliaki og dermatitis herpetiformis. Alene eller sammen - forskjeller i klassifisering og behandling? 

      Hansen, Ingunn Benedicte; Davidsen, Anne (Master thesis; Mastergradsoppgave, 2013-05-07)
      Cøliaki er en autoimmun sykdom som i ubehandlet tilstand medfører redusert næringsopptak fra tynntarmen. Utbredelse av sykdom kan graderes ved en Marsh scoring ved mikroskopering av biopsier fra tarmen. Dermatitis herpetiformis er en hudsykdom som også er autoimmun og gir blemmedannelse i huden. Det er en sterk assosiasjon mellom DH og cøliaki, men DH kan forekomme uten at det er påvist cøliaki. ...