Background:<br> The inflammatory response to community-acquired pneumonia (CAP) is orchestrated through activation of cytokine networks and the complement system. We examined the association of multiple cytokines and the terminal complement complex (TCC) with microbial aetiology, disease severity and shortterm outcome.<br> Materials and methods: <br>Plasma levels of 27 cytokines and TCC were ...

In the present study we examined the ability of the amino acid derivative LTX-401 to induce cell death in cancer cell lines, as well as the capacity to induce regression in a murine melanoma model. Mode of action studies in vitro revealed lytic cell death and release of danger-associated molecular pattern molecules, preceded by massive cytoplasmic vacuolization and compromised lysosomes in treated ...

In a cross-sectional study of 296 children and adolescents from Zimbabwe living with perinatal human immunodeficiency virus, individuals with the top tertile of cytomegalovirus-specific immunoglobulin G titer had an increased odds of chronic lung disease (odds ratio, 3.33; 95% confidence interval, 1.37–8.85; P = .010).

Cøliaki er en autoimmun sykdom som i ubehandlet tilstand medfører redusert næringsopptak fra tynntarmen. Utbredelse av sykdom kan graderes ved en Marsh scoring ved mikroskopering av biopsier fra tarmen. Dermatitis herpetiformis er en hudsykdom som også er autoimmun og gir blemmedannelse i huden. Det er en sterk assosiasjon mellom DH og cøliaki, men DH kan forekomme uten at det er påvist cøliaki. ...

Background - Current guidelines recommend the use of clinical decision rules, such as Wells score, in combination with D-dimer to assess the need for objective imaging to rule out deep vein thrombosis (DVT). However, the clinical decision rule has limitations, and use of D-dimer as a stand-alone test has been suggested.<p> <p>Objective - We aimed to assess the safety and efficiency of D-dimer as ...

Identification of patients at risk of major bleeding is pivotal for optimal management of anticoagulant therapy in venous thromboembolism (VTE). Studies have suggested that D-dimer may predict major bleeding during anticoagulation; however, this is scarcely investigated in VTE patients. We aimed to investigate the role of D-dimer, measured at VTE diagnosis, as a predictive biomarker of major bleeding. ...

Det så mørkt ut for Solveig Flatebøs doktorgradsarbeid da Norge erklærte unntakstilstand i mars i fjor. Så fikk hun en idé som gjorde forskningen mye lettere å gjennomføre.

Bakgrunn: Dagbøker har innvirkning på tidligere intensivpasienters opplevelser av psykiske symptomer. Det er vist reduksjon i forekomst av PTSD, angst og depresjon hos intensivpasienter som mottok dagbok etter intensivbehandling. Intensivsykepleiere er klar over effektene dagbøker har på pasientenes rehabiliteringsprosess, men likevel er ikke virksomheten alltid en førsteprioritet under intensivbehandling. ...

Patients with chronic pain commonly report sleep problems, and the evidence for a relationship between sleep disturbance and pain seems robust. The day‐to‐day associations between these constructs are less well studied, particularly with objective sleep measures such as actigraphy. Moreover, the concurrent presence of negative affective symptoms, as well as seasonality effects at extreme latitudes ...

People are increasingly able to generate their own health data through new technologies such as wearables and online symptom checkers. However, generating data is one thing, interpreting them another. General practitioners (GPs) are likely to be the first to help with interpretations. Policymakers in the European Union are investing heavily in infrastructures to provide GPs access to patient ...