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    • Is smoking associated with patient reported surgical-site infection after fusion surgery in the lumbar spine? 

      Isaksen, Victoria (Master thesis; Mastergradsoppgave, 2018-05-26)
      Introduction: Surgical site infection (SSI) is one of the most common complications in patients undergoing spine surgery. Associations between smoking and SSI have been found in previous studies, but with ambiguous results. This study was designed to compare the postoperative rate of SSI among smokers and non-smokers after fusion surgery in the lumbar spine and evaluate risk factors for SSI. Methods ...

    • Is the Disease Burden from COPD in Norway Falling off? A Study of Time Trends in Three Different Data Sources 

      Melbye, Hasse; Helgeland, Jon; Karlstad, Øystein; Ariansen, Inger; Langhammer, Arnulf; Wisløff, Torbjørn; Nafstad, Per; Nystad, Wenche (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-12)
      <i>Background</i>: Less smoking should lead to fewer COPD cases. We aimed at estimating time trends in the prevalence and burden of COPD in Norway from 2001 to 2017.<p><p> <i>Methods</i>: We used pre-bronchodilator spirometry and other health data from persons aged 40– 84 years in three surveys of the Tromsø Study, 2001– 2002, 2007– 2008 and 2015– 2016. We applied spirometry lower limits of normal ...

    • Is the ongoing obesity epidemic partly explained by concurrent decline in cigarette smoking? Insights from a longitudinal population study. The Tromsø Study 1994–2016 

      Løvsletten, Ola; Njølstad, Inger; Wilsgaard, Tom; Hopstock, Laila Arnesdatter; Jacobsen, Bjarne K.; Bønaa, Kaare Harald; Eggen, Anne Elise; Løchen, Maja-Lisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-23)
      <p>The increase of obesity coincides with a substantial decrease in cigarette smoking. We assessed post-cessation weight change and its contribution to the obesity epidemic in a general population in Norway. A total of 14,453 participants (52.6% women), aged 25–54 years in 1994, who attended at least two of four surveys in the Tromsø Study between 1994 and 2016, were included in the analysis. Hereof ...

    • Is the operative delivery rate in low-risk women dependent on the level of birth care? : a randomised controlled trial 

      Bernitz, Stine; Rolland, Rune; Blix, Ellen; Jacobsen, Morten; Sjøborg, Katrine Dønvold; Øian, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Objective: To investigate possible differences in operative delivery rate among low-risk women, randomised to an alongside midwifery-led unit or to standard obstetric units within the same hospital. Design: Randomised controlled trial. Setting: Department of Obstetrics and Gynaecology, Østfold Hospital Trust, Tromsø, Norway. Population: A total of 1111 women assessed to be at low risk at onset ...

    • Is the presence of foraminal stenosis associated with outcome in lumbar spinal stenosis patients treated with posterior microsurgical decompression 

      Aaen, Jørn Ståle; BANITALEBI, HASAN; Austevoll, Ivar Magne; Hellum, Christian; Storheim, Kjersti; Myklebust, Tor Åge; Anvar, Masoud D; Weber, Clemens; Solberg, Tore; Grundnes, Oliver; Brisby, Helena; Indrekvam, Kari; Hermansen, Erland (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-05)
      Background We aim to investigate associations between preoperative radiological findings of lumbar foraminal stenosis with clinical outcomes after posterior microsurgical decompression in patients with predominantly central lumbar spinal stenosis (LSS).<p> <p>Methods The study was an additional analysis in the NORDSTEN Spinal Stenosis Trial. In total, 230 men and 207 women (mean age 66.8 (SD ...

    • Is there a different effect of excess body weight on cancer risk in type 1 and type 2 endometrial cancer? 

      Sollberger, Tanja Lise (Master thesis; Mastergradsoppgave, 2019-03-12)
      Background: Endometrial cancer (EC) is the fifth most common type of cancer in women worldwide being responsible for 4.8% of all cancers in women. From large cohort studies there is consistent evidence for a positive association between excess body weight and different cancer types. Women with excess body weight stands out as having a particularly high relative risk for EC. Excess body weight is an ...

    • Is there a negative impact of winter on mental distress and sleeping problems in the sub-arctic? 

      Johnsen, May Trude; Wynn, Rolf; Bratlid, trond (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)

    • Is there a seasonal variation of survival after systemic chemotherapy for metastatic castration-resistant prostate cancer in a rural part of North Norway? 

      Nieder, Carsten; Dalhaug, Astrid; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-19)
      The winter darkness or polar night induces endocrine and metabolic mechanisms, which might reduce the efficacy of cancer treatment and thus contribute to shorter survival. Moreover, season-and weather-related treatment delays and irregularities might also cause reduced efficacy of anti-cancer drugs. Therefore, this study evaluated the prognostic impact of timing of chemotherapy (start during winter ...

    • Is there a weekly pattern for health information searching and is the pattern unique to health topics? 

      Gabarron, Elia; Lau, Annie YS; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12)
      Background: Online health information–seeking behaviors have been reported to be more common at the beginning of the workweek. This behavior pattern has been interpreted as a kind of “healthy new start” or “fresh start” due to regrets or attempts to compensate for unhealthy behavior or poor choices made during the weekend. However, the observations regarding the most common health information–seeking ...

    • Is traditional Chinese medicine recommended in Western medicine clinical practice guidelines in China? A systematic analysis 

      Ren, Jun; Li, Xun; Sun, Jin; Han, Mei; Yang, Guo-Yan; Li, Wen-Yuan; Robinson, Nicola; Lewith, George; Liu, Jianping (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-03)
      Background: Evidence-based medicine promotes and relies on the use of evidence in developing clinical practice guidelines (CPGs). The Chinese healthcare system includes both traditional Chinese medicine (TCM) and Western medicine, which are expected to be equally reflected in Chinese CPGs. <p>Objective: To evaluate the inclusion of TCM-related information in Western medicine CPGs developed ...

    • Is working in a cold environment associated with musculoskeletal complaints 7–8 years later? A longitudinal analysis from the Tromsø Study 

      Farbu, Erlend Hoftun; Höper, Anje Christina; Brenn, Tormod; Skandfer, Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-23)
      <i>Objective</i> - Exposure to a cold environment at work is associated with a higher prevalence of musculoskeletal pain and chronic pain in cross-sectional studies. This study aims to determine the association between working in a cold environment ≥ 25% of the time and musculoskeletal complaints (MSC) 7–8 years later.<p> <p><i>Methods</i> - We followed participants from the sixth survey (Tromsø ...

    • Iscenesettelse av kulturelt demokrati: sett i lys av omsorgsregimer 

      Gjærum, Rikke Gürgens (Chapter; Bokkapittel, 2017)
      Dette kapittelet utforsker hvordan det kulturelle demokratiet iscenesettes i omsorgstjenester for mennesker med demens, for borgere på flukt og for psykiatriske pasienter i dagens Velferds-Norge. Kunstens potensial til å fremstå som et alternativt omsorgsregime diskuteres i lys av kunstdidaktikk, marginalisering og det Eichmannske problem. Kapittelet bygger på en studie bestående av tre analyser ...

    • Ischemic stroke and risk of venous thromboembolism in the general population. The Tromsø study 

      Rinde, Ludvig Balteskard (Master thesis; Mastergradsoppgave, 2017-10-21)
      Background: Even though clinical data support a relation between ischemic stroke and venous thromboembolism (VTE), the strength and time dependence of the association remain to be settled at the population level. We therefore aimed to investigate the association between ischemic stroke and VTE in a prospective population-based cohort. Methods and Results: Participants (n=30 002) were recruited from ...

    • Ischemic Stroke and Risk of Venous Thromboembolism in the General Population: The Tromsø Study 

      Balteskard Rinde, Ludvig; Småbrekke, Birgit; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa; Njølstad, Inger; Mathiesen Hald, Erin; Wilsgaard, Tom; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-07)
      <i>Background</i> - Even though clinical data support a relation between ischemic stroke and venous thromboembolism (VTE), the strength and time dependence of the association remain to be settled at the population level. We therefore aimed to investigate the association between ischemic stroke and VTE in a prospective population-based cohort.<p> <p><i>Methods and Results</i> - Participants (n=30 ...

    • Ischemic stroke in a general population: Time trends in incidence, case fatality and the impact of risk factors. 

      Vangen-Lønne, Anne Merete (Doctoral thesis; Doktorgradsavhandling, 2017-10-13)
      About 80-85% of all strokes are due to reduced blood flow to the brain (ischemic strokes). Lack of knowledge regarding time trends in incidence and case fatality of ischemic stroke in Norway represented a main motivation for this study. Data from the Tromsø Study, following >40,000 attendees from six surveys through 2012, provided an excellent opportunity to reveal time trends of ischemic stroke and ...

    • Isjiaslignende smerter med utgangspunkt i hofta. En litteraturgjennomgang av piriformissyndrom og presentasjon av en studie av det nylig beskrevne obturatorius internussyndrom. 

      Moen, Åshild (Master thesis; Mastergradsoppgave, 2004)

    • Isocaloric substitution of carbohydrates with protein: The association with weight change and mortality among patients with type 2 diabetes 

      Campmans-Kuijpers, Marjo J.E.; Sluijs, Ivonne; Nöthlings, Ute; Freisling, Heinz; Overvad, Kim; Weiderpass, Elisabete; Fagherazzi, Guy; Kühn, Tilman; Katzke, Verena A.; Mattiello, Amalia; Sonestedt, Emily; Masala, Giovanna; Agnoli, Claudia; Tumino, Rosario; Spijkerman, Annemieke M.W.; Barricarte, Aurelio; Ricceri, Fulvio; Chamosa, Saioa; Johansson, Ingegerd; Winkvist, Anna; Tjønneland, Anne; Sluik, Diewertje; Boeing, Heiner; Beulens, Joline W.J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-18)
      Background: The health impact of dietary replacement of carbohydrates with protein for patients with type 2 diabetes is still debated. This study aimed to investigate the association between dietary substitution of carbohydrates with (animal and plant) protein and 5-year weight change, and all-cause and cardiovascular (CVD) mortality risk in patients with type 2 diabetes. <p>Methods: The study ...

    • Isoflurane increases tolerance to renal ischemia reperfusion injury compared to propofol: An experimental study in pigs 

      Roaldsen, Marius Håke; Ciosek, Timothy Allan; Richardsen, Elin; Al-Saad, Samer; Patel, Hitendra R.H.; Aarsæther, Erling Johan (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-09)
      <i>Purpose</i>: To compare two clinically relevant anesthetic agents, i.e., isoflurane versus propofol with respect to protection of the kidney in a porcine renal ischemia reperfusion model. <p> <p><i>Materials and Methods</i>: 14 hybrid pigs were randomized to anesthesia with either isoflurane or propofol prior to laparoscopic surgery. Following anesthesia, the left kidney hilum was clamped for ...

    • The isolated perfused human skin flap model: A missing link in skin penetration studies? 

      Ternullo, Selenia; de Weerd, Louis; Flaten, Gøril Eide; Holsæter, Ann Mari; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-05)
      Development of effective (trans)dermal drug delivery systems requires reliable skinmodels to evaluate skin drug penetration. The isolated perfused human skin flap remainsmetabolically active tissue for up to 6 h during in vitro perfusion. We introduce the isolated perfused human skin flap as a close-to-in vivo skin penetration model. To validate the model's ability to evaluate skin drug penetration ...

    • Isolated perfused working hearts provide valuable additional information during phenotypic assessment of the diabetic mouse heart 

      Pedersen, Tina Myhre; Boardman, Neoma; Hafstad, Anne Dragøy; Aasum, Ellen (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-01)
      Although murine models for studying the development of cardiac dysfunction in diabetes mellitus are well established, their reported cardiac phenotypes vary. These reported divergences may, in addition to the severity of different models, also be linked to the methods used for cardiac functional assessment. In the present study, we examined the functional changes using conventional transthoracic ...