Neuroblastoma is the most common diagnosed tumor in infants and the second most common extracranial tumor of childhood. The survival rate of patients with high-risk neuroblastoma is still very low despite intensive multimodal treatments. Therefore, new treatment strategies are needed. In recent years, miRNA-based anticancer therapy has received growing attention. Advances in this novel treatment ...

MicroRNAs (miRNAs) are small non-coding RNAs that function in RNA silencing and post-transcriptional regulation of gene expression in most organisms. The water flea, <i>Daphnia magna</i> is a key model to study phenotypic, physiological and genomic responses to environmental cues and miRNAs can potentially mediate these responses. By using deep sequencing, genome mapping and manual curations, we ...

Aims: The Tromsø Study 1979–1980 collected information on alcohol (beer, wine and spirits) consumption frequency and inebriation frequency, and the oldest male participants (aged 50–54 years) were followed for all-cause mortality. This study aimed to identify the impact of habitual alcohol consumption in mid-life on reaching up to 90 years of age. Results: Among the study sample of 778, a total ...

Osteoarthritis is the most common form of arthritis. For glenohumeral osteoarthritis the gold standard treatment for end stage disease is arthroplasty with stemmed prosthesis. The trend surrounding shoulder arthroplasty focuses on reducing stem-related complication, but mid- to long-term studies on stemless hemiarthroplasty are needed to evaluate durability. Our hypothesis was that stemless ...

Aim - To investigate midwives' (MWs) and public health nurses' (PHNs) clinical practice and knowledge related to nutrition, with a particular focus on iodine in northern parts of Norway. Maternal iodine status prior to and during pregnancy, and the lactating period, is crucial for brain development and growth of the foetus and infant, from conception up until the first two years of life. In Norway, ...

The museum of reconstruction for Finnmark and Northern Troms uses personal war memories from childhood and adolescence e.g. in exhibitions, articles and lectures. However, 70-year-old memories are most likely processed and changed over time, and critics often consider memories untrustworthy. Some scholars claim that positive memories stick better than negative memories, while others vice versa. ...

<i>Introduction</i>: A minimal increase in the albumin-to-creatinine ratio (ACR) predicts cardiovascular disease and mortality, but whether it predicts kidney function loss in nondiabetic persons is unclear. We investigated the association between ACR in the optimal or high-normal range and the rate of glomerular filtration rate (GFR) decline in a cohort from the general population without diabetes, ...

Nalmefene is approved for as-needed pharmacological treatment in alcohol use disorder (AUD) by the European Medicines Agency. While the cellular effects of nalmefene have been thoroughly investigated, data are very limited on how this agent influences neural signals associated with inhibitory control and the visual analysis of environmental cues. This double-blind crossover study assessed the ...