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MS og miljøfaktorer 2003
(Master thesis; Mastergradsoppgave, 2003-09-15) -
MS og oral helse, litteraturstudie. Multiple sclerosis and oral Health, a review of Norwegian and international literature.
(Master thesis; Mastergradsoppgave, 2015-05-19)Denne oppgaven er en litteraturstudie som omhandler oral helse for pasienter med Multippel sklerose der jeg har sett nærmere på hvilken literatur som finnes i Norge og internasjonalt om emnet MS og oral helse. Multippel sklerose (MS) er en kronisk neurodegenerativ sykdom som er funnet hos 203 personer pr 100´000 i Norge. Det finnes i dag lite informasjon og kunnskap i Norge om Multippel skleroses ... -
MS-registeret: tid fra første symptom til diagnose, fra diagnose til behandling og medikamentvalg i Troms og Finnmark
(Master thesis; Mastergradsoppgave, 2020-02-21)Bakgrunn: Tid fra diagnose til behandlingsstart og behandlingsfrekvens er viktige kvalitetsmål for behandlingen ved multippel sklerose. Nasjonale faglige retningslinjer og årlige LIS-anbefalinger (Legemiddelinnkjøpssamarbeid) er gjeldende for valg av medikament ved oppstart av behandling. Nevrologisk avdeling ved UNN Tromsø bruker MS-registeret for å kvalitetssikre behandlingen av personer med ... -
Mucoadhesive buccal films based on a graft co-polymer – A mucin-retentive hydrogel scaffold
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-07)From a patient-centric perspective, oromucosal drug delivery is highly attractive due to the ease of administration without the need of swallowing, and improved patient safety. The aim of the presented work was to prepare a buccal film using a self-forming micellar drug solubiliser as the film matrix, combining it with a mucoadhesive polymer for an enhanced retention on the buccal mucosa. Specifically, ... -
Mucoadhesive liposomal delivery systems : the choice of coating material
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)Development of liposomal mucoadhesive drug delivery system, which is able to improve the bioavailability of poorly absorbed oral drugs by prolonging their gastric and intestinal residence time, through facilitating the intimate contact of the delivery system with the absorption membrane. Liposomes containing model drug atenolol were prepared by the modified ethanol injection method. Liposomes ... -
Mucoadhesive liposomes as new formulation for vaginal delivery of curcumin
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Mucosal cytokine profiles as biomarkers in inflammatory bowel disease -Translating molecular biology into clinical medicine
(Doctoral thesis; Doktorgradsavhandling, 2013-01-11)Patogenesen ved inflammatorisk tarmsykdom (IBD) er fortsatt ikke fullstendig klarlagt. Mye forskning har blitt gjort de siste tjue årene for å kartlegge immunresponsen ved ulcerøs kolitt og Crohns sykdom. Man antar at et samspill mellom genetiske faktorer, miljøfaktorer og bakterier ligger bak utviklingen av sykdommen. Kartleggingen av immunresponsen i tarmen har vært grunnlaget for utviklingen av ... -
Mucosal gene transcription of ulcerative colitis in endoscopic remission
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-09)<i>Aim/Objective</i>: Ulcerative colitis (UC) is a chronic inflammatory bowel disease. In UC, a wide range of criteria are used for disease remission, with few studies investigating the differences between disease remission and normal control groups. This paper compares known inflammatory and healing mediators in the mucosa of UC in clinical remission and normal controls, in order to better describe ... -
Mucosal Metabolomic Profiling and Pathway Analysis Reveal the Metabolic Signature of Ulcerative Colitis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-27)The onset of ulcerative colitis (UC) is characterized by a dysregulated mucosal immune response triggered by several genetic and environmental factors in the context of host–microbe interaction. This complexity makes UC ideal for metabolomic studies to unravel the disease pathobiology and to improve the patient stratification strategies. This study aims to explore the mucosal metabolomic profile in ... -
Mucus-penetrating drug carriers for vaginal drug delivery
(Master thesis; Mastergradsoppgave, 2015-05-13)Vaginal drug administration is a challenging approach due to the body´s natural defense mechanisms and specificity in formulation design. However, where applicable, topical drug delivery is preferable to systemic therapy. Firstly, it allows averting hepatic first pass effect and degradation by GI enzymes. Secondly, non-invasive application provides closer and direct contact with the affected area ... -
Mucus-PVPA (mucus Phospholipid Vesicle-based Permeation Assay): An artificial permeability tool for drug screening and formulation development
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-26)The mucus layer covering all mucosal surfaces in our body is the first barrier encountered by drugs before their potential absorption through epithelial tissues, and could thus affect the drugs’ permeability and their effectiveness. Therefore, it is of key importance to have in vitro permeability models that can mimic this specific environment. For this purpose, the novel mucus phospholipid vesicle-based ... -
Muggsoppforekomst i boliger i subarktisk miljø hos barn med og uten astmasymptomer.
(Master thesis; Mastergradsoppgave, 2004) -
Mukus-penetrerende legemiddelbærere: hvordan modifisering av overflaten påvirker terapeutisk effekt
(Master thesis; Mastergradsoppgave, 2014-05-20)Seksuelt overførbare infeksjoner og andre gynekologiske sykdommer vil man helst behandle lokalt. Hos kvinner er vaginal administrasjon fordelaktig for behandling av nettopp slike sykdommer. Det er flere utfordringer som må overvinnes når farmasøytiske formuleringer til vaginal administrasjon skal utvikles; vagina har en evne til å rense seg selv, det skjer hele tiden fysiologiske forandringer i ... -
Muligheter og begrensninger ved fokusgruppemetodikk : fokusgrupper anvendt i studier av kvalitet i pleie- og omsorgsektoren i kommunehelsetjenesten
(Research report; Forskningsrapport, 2008) -
A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-02)The COVID-19 pandemic has increased negative emotions and decreased positive emotions globally. Left unchecked, these emotional changes might have a wide array of adverse impacts. To reduce negative emotions and increase positive emotions, we tested the effectiveness of reappraisal, an emotion-regulation strategy that modifies how one thinks about a situation. Participants from 87 countries and ... -
A multi-lab test of the facial feedback hypothesis by the Many Smiles Collaboration
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-20)Following theories of emotional embodiment, the facial feedback hypothesis suggests that individuals’ subjective experiences of emotion are influenced by their facial expressions. However, evidence for this hypothesis has been mixed. We thus formed a global adversarial collaboration and carried out a preregistered, multicentre study designed to specify and test the conditions that should most reliably ... -
Multi-Locus variable number of tandem repeat analysis for rapid and accurate typing of virulent multidrug resistant escherichia coli clones
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)One hundred E. coli isolates from Norway (n = 37), Sweden (n = 24), UK (n = 20) and Spain (n = 19), producing CTX-M-type - (n = 84), or SHV-12 (n = 4) extended spectrum β-lactamases, or the plasmid mediated AmpC, CMY-2 (n = 12), were typed using multi-locus sequence typing (MLST) and multi-locus variable number of tandem repeat analysis (MLVA). Isolates clustered into 33 Sequence Types (STs) and 14 ... -
Multi-scale modeling of drug binding kinetics to predict drug efficacy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-25)Optimizing drug therapies for any disease requires a solid understanding of pharmacokinetics (the drug concentration at a given time point in different body compartments) and pharmacodynamics (the effect a drug has at a given concentration). Mathematical models are frequently used to infer drug concentrations over time based on infrequent sampling and/or in inaccessible body compartments. Models are ... -
Multi-scale modeling of drug binding kinetics to predict drug efficacy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-25)Optimizing drug therapies for any disease requires a solid understanding of pharmacokinetics (the drug concentration at a given time point in different body compartments) and pharmacodynamics (the effect a drug has at a given concentration). Mathematical models are frequently used to infer drug concentrations over time based on infrequent sampling and/or in inaccessible body compartments. Models are ... -
Multi-site musculoskeletal pain in mine workers exposed to cold environment
(Master thesis; Mastergradsoppgave, 2015-05-30)Objectives: We aimed to examine the prevalence of musculoskeletal single- and multi-site pain and exposure factors from two high north mining populations. In addition, we aimed to analyze for possible associations between perceived cold and pain in single and multiple locations. Methods: This study follows a cross sectional epidemiological design. Data was collected by questionnaire among 254 ...
