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    • Mutasjonstesting ved ikke-småcellet lungekreft 

      Brustugun, Odd Terje; Helland, Åslaug; Fjellbirkeland, Lars; Kleinberg, Lilach; Ariansen, Sarah Louise; Jebsen, Peter Wilhelm; Scott, Helge; Dønnem, Tom; Bremnes, Roy M.; Berg, Thomas; Grønberg, Bjørn Henning; Dai, Hong Yan; Wahl, Sissel Gyrid Freim; Mangseth, Kjersti; Helgeland, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-04-30)
      Bakgrunn. Epidermal vekstfaktorreseptor (EGFR) tyrosinkinasehemmere (EGFR-TKI) er en relativt ny klasse legemidler til behandling av ikke-småcellet lungekreft. Den nasjonale faggruppen for lungekreft, Norsk Lunge Cancer Gruppe, anbefaler at pasienter med ikke-småcellet lungekreft testes for mutasjoner i EGFRgenet. Vi rapporterer her erfaringene som er gjort etter at slik testing ble innført i ...

    • Mutation analysis of the FHL2 gene in human prostate and mammae cancer 

      Teigan, Are Bjarke; Molund, Marius (Master thesis; Mastergradsoppgave, 2004-05-06)

    • Mutational drivers of a dysfunctional local immune response in resected non-small cell lung cancer (NSCLC) patients 

      Holmstad, Patrick (Master thesis; Mastergradsoppgave, 2023-05-30)
      Background: Patients with KEAP1 and STK11 alterations have shown poor response to immunotherapy in non-small cell lung cancer (NSCLC) due to unknown underlying mechanisms. In a sub-study of the TNM-I trial (NCT03299478), we discovered that lung adenocarcinomas (LUAD) with concurrent KEAP1 and STK11 mutations exhibit predominantly non-inflamed immunological features, potentially contributing to ...

    • "My cancer is not my deepest concern": life course disruption influencing patient pathways  and health care needs among persons living with colorectal cancer 

      Salamonsen, Anita; Kiil, Mona Anita; Kristoffersen, Agnete Egilsdatter; Stub, Trine; Berntsen, Gro R. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-17)
      <b>BACKGROUND: </b> The concept of "patient pathways" in cancer care is most commonly understood as clinical pathways, operationalized as standardized packages of health care based on guidelines for the condition in question. In this understanding, patient pathways do not address multimorbidity or patient experiences and preferences. This study explored patient pathways understood as the individual ...

    • “My cousin said to me ...” Patients’ use of 3rd-party references to facilitate shared decision-making during naturally occurring primary care consultations. 

      Lian, Olaug S; Nettleton, Sarah Joan; Grange, Huw Robert; Dowrick, Christopher (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-30)
      In this paper, we explore the ways in which patients invoke third parties to gain decision-making influence in clinical consultations. The patients’ role in decision-making processes is often overlooked, and this interactional practice has rarely been systematically studied. Through a contextual narrative exploration of 42 naturally occurring consultations between patients (aged 22–84) and general ...

    • MYCN and microRNAs in neuroblastoma 

      Büchner, Jochen (Doctoral thesis; Doktorgradsavhandling, 2011-09-30)
      Neuroblastoma is the most common extra-cranial solid tumor in childhood. Tumors with amplification of the MYCN proto-oncogene are characterized by aggressive biology and poor survival of the patients. To improve future treatment options, it is of fundamental interest to understand MYCN’s role in tumorigenesis and determine factors regulating MYCN expression. In this thesis focuses on the interactions ...

    • MYCN-regulated miRNAs Inhibit Secretion of the Tumor Suppressor DICKKOPF-3 (DKK3) in Neuroblastoma 

      Haug, Bjørn Helge; Henriksen, Jørn Remi; Buechner, Jochen; Kogner, Per; Martinsson, Tommy; Flægstad, Trond; Sveinbjørnsson, Baldur; Einvik, Christer (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      The MYCN oncogene is frequently amplified in neuroblastoma. It is one of the most consistent markers of a bad prognosis for this disease. Dickkopf-3 (DKK3) is a secreted protein of the Dickkopf family of Wnt regulators. It functions as a tumor suppressor in a range of cancers, including neuroblastoma. MYCN was recently found to downregulate DKK3 mRNA. In this study, we show that MYCN knockdown in ...

    • Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort 

      Claeys, Liesel; De Saeger, Sarah; Scelo, Ghislaine; Biessy, Carine; Casagrande, Corinne; Nicolas, Genevieve; Korenjak, Michael; Fervers, Beatrice; Heath, Alicia K.; Krogh, Vittorio; Luján-Barroso, Leila; Castilla, Jesús; Ljungberg, Börje; Rodriguez-Barranco, Miguel; Ericson, Ulrika; Santiuste, Carmen; Catalano, Alberto; Overvad, Kim; Brustad, Magritt; Gunter, Marc J.; Zavadil, Jiri; De Boevre, Marthe; Huybrechts, Inge (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-30)
      Background: Mycotoxins have been suggested to contribute to a spectrum of adverse health effects in humans, including at low concentrations. The recognition of these food contaminants being carcinogenic, as co-occurring rather than as singularly present, has emerged from recent research. The aim of this study was to assess the potential associations of single and multiple mycotoxin exposures with ...

    • Myelinated Retinal Nerve Fibre: Prevalence and its Association with Ocular and Systemic Parameters in Tromsø. 

      Kalu, Dominic Okoro (Mastergradsoppgave; Master thesis, 2020-11-30)
      Background: Myelinated retinal nerve fibres (MRNFs) are congenital anomalies of the fundus that occur in about 1% of the population. Clinically, they appear as grey or white well-separated patches with feathery borders along the retinal nerve fibre layer. MRNF has been reported to occur in association with some ocular parameters as well as stroke. However, most cases of MRNF occur in isolation and ...

    • Myelomatose i Nord-Norge 2005-2015 

      Lauvås, Kenneth (Master thesis; Mastergradsoppgave, 2017-09-20)
      Bakgrunn: Myelomatose er den tredje vanligste hematologiske kreftsykdommen med en insidensrate på 6,5 per 100,000. Sykdommen kjennetegnes av akkumulering av plasmaceller i beinmargen, og utvikler seg alltid gjennom forstadiet MGUS. Symptomene er lite spesifikke og diagnostikken er omfattende. Myelomatose meldes til kreftregisteret, men kreftregisteret publiserer ikke overlevelsesdata for landet som ...

    • Myfood24 på norsk: et selvadministrert digitalt 24-timers kostintervju 

      Valen, Erlend Larsen; Grasaas, Erik; Engeset, Dagrun; Salvesen, Lorentz; Skeie, Guri; Øverby, Nina Cecilie; Medin, Anine Christine (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-16)
      Innen ernæringsepidemiologien er vi i stor grad avhengige av å estimere inntak av mat og næringsstoffer basert på selvrapportering, til tross for at denne tilnærmingen er beheftet med målefeil. Graden av målefeil har betydning for analyser og tolkning av resultater, så metodene vi bruker bør være så valide som mulig. Å utvikle brukervennlige kostholdsmetoder som reduserer belastning for deltaker kan ...

    • Myocardial infarction and future risk of cancer in the general population—the Tromsø Study 

      Rinde, Ludvig Balteskard; Småbrekke, Birgit; Mathisen Hald, Erin; Brodin, Ellen Elisabeth; Njølstad, Inger; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa; Wilsgaard, Tom; Brækkan, Sigrid Kufaas; Vik, Anders; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-07)
      The association between myocardial infarction (MI) and future risk of incident cancer is scarcely investigated. Therefore, we aimed to study the risk of cancer after a first time MI in a large cohort recruited from a general population. Participants in a large population-based study without a previous history of MI or cancer (n = 28,763) were included and followed from baseline to date of cancer, ...

    • Myocardial Infarction as a Risk Factor of Developing Heart Failure - The Tromsø Study 

      Dalen, Karoline (Master thesis; Mastergradsoppgave, 2018-06-04)
      Background and aim: 1-2% suffer from heart failure (HF), and the prevalence increases by age. Lifetime risk for HF is highest among men. Myocardial infarction (MI) is a recognized risk factor for HF while HF is associated with increased mortality. The aims for this thesis are to investigate how MI affects the risk of subsequent HF in both genders, in different age groups and whether education has ...

    • Myocardial infarction as a transient risk factor for incident venous thromboembolism: Results from a population-based case-crossover study 

      Sejrup, Joakim Knutsen; Børvik, Trond; Grimnes, Gro; Isaksen, Trond; Hindberg, Kristian; Hansen, John-Bjarne; Morelli, Vania Maris; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-16)
      Patients with myocardial infarction (MI) are at increased short-term risk of venous thromboembolism (VTE). The mechanisms behind this association are unclear. We aimed to investigate the impact of acute MI as a transient risk factor for incident VTE while taking other concomitant VTE risk factors into account. We conducted a case–crossover study of VTE patients (<i>n</i> = 707) recruited from the ...

    • Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: The Tromsø Study 

      Sejrup, Joakim Knutsen; Morelli, Vania Maris; Løchen, Maja-Lisa; Njølstad, Inger; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Hansen, John-Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed; Master thesis; Mastergradsoppgave, 2020-01-27)
      <p><i>Background - </i>The risk of venous thromboembolism (VTE) is increased after a myocardial infarction (MI). Some prothrombotic genotypes associated with VTE have also been associated with risk of MI. Whether prothrombotic single‐nucleotide polymorphisms (SNPs) further increase the risk of VTE in MI patients is scarcely investigated. <p><i>Aim - </i>To study the combined effect of MI and ...

    • Myocardial metabolic, structural and functional remodelling following nutritional and hormonal stress 

      Hansen, Synne Simonsen (Doctoral thesis; Doktorgradsavhandling, 2022-06-22)
      The overall aim of this thesis was to increase our knowledge related to the underlying mechanisms of diabetes-induced cardiomyopathy. The primary objective of the first two papers was to elucidate the role of the reactive oxygen species (ROS) producing enzyme, NADPH oxidase 2 (NOX2), in the development of cardiac dysfunction in obesity/diabetes. We also wanted to examine the potential link between ...

    • Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise 

      Hancock, Matthew; Hafstad, Anne Dragøy; Nabeebaccus, Adam A.; Catibog, Norman; Logan, Angela; Smyrnias, Ioannis; Hansen, Synne Simonsen; Lanner, Johanna; Schröder, Katrin; Murphy, Michael P.; Shah, Ajay M.; Zhang, Min (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-27)
      Regular exercise has widespread health benefits. Fundamental to these beneficial effects is the ability of the heart to intermittently and substantially increase its performance without incurring damage, but the underlying homeostatic mechanisms are unclear. We identify the ROSgenerating NADPH oxidase-4 (Nox4) as an essential regulator of exercise performance in mice. Myocardial Nox4 levels ...

    • Myocardial tissue Doppler velocities in fetuses with hypoplastic left heart syndrome. 

      Vyas, HV; Eidem, BW; Cetta, F; Acharya, Ganesh; Huhta, J.; Roberson, D; Cuneo, B (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Tissue Doppler Imaging (TDI) is a sensitive index of myocardial function. Its role in the fetus has not been extensively evaluated. To compare myocardial tissue Doppler velocities in fetuses with hypoplastic left heart syndrome (HLHS) to those of normal fetuses (matched for gestational age.) Cross-sectional retrospective study conducted at 2 large perinatal centers (2003-2007). Fetuses with HLHS ...

    • Møte mellom flyktninger og helsevesenet 

      Øseth, Heidi (Master thesis; Mastergradsoppgave, 2008-10-23)
      Sammendrag Bakgrunnen for denne masteroppgave er å prøve å forstå hvordan møtefeltet mellom allmennleger og flyktningpasienter oppleves for partene. Det å se på hvordan kommunikasjonen fungerer, og hvilke utfordringer de står overfor hverandre i samhandlingen. Jeg anlegger et hermeneutisk perspektiv. Som er mitt teoretiske verktøy gjennom oppgaven. Der jeg velger hermeneutiker Hans-Georg Gadamer. ...

    • Møter med kvinner som kommer i brachyterapi 

      Qaitouri, Marzieh (Master thesis; Mastergradsoppgave, 2016-05-10)
      Sammendrag: Studiens utgangspunkt er stråleterapeuters erfaringer med å behandle kvinner med livmorhalskreft i brachyterapi. Studien er forankret i stråleterapeutens perspektiv for hvordan de ivaretar disse kvinner som møter en del utfordringer i brachyterapi og i forbindelse med brachyterapibehandling.Studien har et strategisk utvalg på fire stråleterapeuter fra to forskjellige sykehus. Studien ...