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ATG8s in the nucleus: Beyond the autophagy paradigm
(Doctoral thesis; Doktorgradsavhandling, 2024-05-23)Selective autophagy is responsible for the lysosomal degradation of damaged or unnecessary cellular components, via a mechanism that acts in the cytoplasm. This process is crucial for cellular health and the responses to stress. In this study, we looked at a specific group of proteins, called ATG8s, which according to published literature, acts along with the selective autophagy receptors as the ... -
ATG9A protects the plasma membrane from programmed and incidental permeabilization.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-12)The integral membrane protein ATG9A plays a key role in autophagy. It displays a broad intracellular distribution and is present in numerous compartments, including the plasma membrane (PM). The reasons for the distribution of ATG9A to the PM and its role at the PM are not understood. Here, we show that ATG9A organizes, in concert with IQGAP1, components of the ESCRT system and uncover cooperation ... -
Atherosclerotic risk factors and risk of myocardial infarction and venous thromboembolism; Time-fixed versus time-varying analyses. The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-16)<i>Background:</i> Single measurements of modifiable risk factors may underestimate associations with outcomes in cohorts. We aimed to compare risk estimates of myocardial infarction (MI) and venous thromboembolism (VTE) by atherosclerotic risk factors during long follow-up using time-fixed analyses without and with correction for regression dilution and time-varying analyses.<p> <p><i>Methods:</i> ... -
The ATLET study: Can subjects with long-standing motor incomplete spinal cord injury learn to walk? A randomized clinical trial
(Doctoral thesis; Doktorgradsavhandling, 2020-05-19)Body-weight supported locomotor training (BWSLT) has been used to improve walking function in subjects with incomplete Spinal Cord Injuries (SCI), but randomized controlled trials (RCTs) among subjects with long-standing (>2 years) incomplete SCI and poor walking function are scarce. This research aims to describe the methodology and report the results from two parallel, but independent, single-blinded ... -
Atopic disease in relation to Staphylococcus aureus carriage and spa type distribution in a subarctic adult population
(Master thesis; Mastergradsoppgave, 2019-06-02)Atopic diseases are common, and the atopic epidemic has ravaged through the westernized countries and is heading for the developing countries too. Despite being a common disease, however, treatment and diagnostic options are still lacking. The immune system and development of atopic disease are interconnected with the environment through exposures or lack thereof. The microbiota of the mucosal ... -
Atopisk eksem og forverrende faktorer
(Master thesis; Mastergradsoppgave, 2013-05-24)Målet med oppgaven var å kartlegge faktorer som kan virke forverrende på et barn med atopisk eksem. Dette er viktig for å hjelpe foreldre til å se sammenhengen mellom symptomer og hva som utløser de, for å kunne lettere behandle og forebygge eksemet. Første del av oppgaven gir en innføring i atopisk eksem og forverrende faktorer. Det ble gjort en inndeling av faktorene etter virkemåte. Andre del ... -
Atopisk eksem og matvareoverfølsomhet, er det en sammenheng?
(Master thesis; Mastergradsoppgave, 2009-08-27)Atopisk eksem er en vanlig sykdom blant små barn, særlig i den vestlige delen av verden, og det ser ut til at forekomsten er økende. Atopisk eksem ser ofte ut til å ha en sammenheng med sykdommer som matvareallergi, astma og allergisk rhinitt. Mange mistenker at matvarer kan ha en betydning for eksemet. Oppgaven fokuserer på den eventuelle sammenhengen gjennom en litteraturstudie, og resultatene fra ... -
Atopisk eksem og tilfredshetsundersøkelse blant deltakerne på Eksemskolen ved Lærings- og mestringssenteret, Universitetssykehuset Nord-Norge, perioden 2003-2007.
(Master thesis; Mastergradsoppgave, 2008-09-15)Første del av oppgaven gir en generell innføring i atopisk eksem. Andre del tar for seg tilfredshetsundersøkelsen foretatt blant deltakerne ved Eksemskolen. Frem til utgangen av 2007 er det blitt avholdt 12 eksemskoler. Ved hjelp av statistikkprogrammet SPSS 15 er datamaterialet fra tilfredshetsundersøkelsen sammenfattet i denne oppgaven. På grunn av et lite tallmateriale har man, som forventet, ... -
ATPase activity of DFCP1 controls selective autophagy
(Journal article; Tidsskriftartikkel, 2023-07-08)Cellular homeostasis is governed by removal of damaged organelles and protein aggregates by selective autophagy mediated by cargo adaptors such as p62/SQSTM1. Autophagosomes can assemble in specialized cup-shaped regions of the endoplasmic reticulum (ER) known as omegasomes, which are characterized by the presence of the ER protein DFCP1/ZFYVE1. The function of DFCP1 is unknown, as are the mechanisms ... -
Atrial Fibrillation and Cause-Specific Risks of Pulmonary Embolism and Ischemic Stroke
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-29)<p><i>Background</i>: Atrial fibrillation (AF) is a well‐established risk factor for ischemic stroke (IS). Emerging evidence also indicates an association between AF and pulmonary embolism (PE). Because IS may potentially mediate the observed risk of PE in AF, we aimed to assess the impact of AF on the cause‐specific risks of PE and IS in a large cohort recruited from the general population.</p> ... -
Atrial fibrillation and future risk of venous thromboembolism:the Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Atrial fibrillation in The Tromsø Study 1994-2007. Risk factors, occurrence and gender differences.
(Doctoral thesis; Doktorgradsavhandling, 2016-01-14)Summary Atrial fibrillation (AF) is a common cardiac arrhythmia, which increases morbidity and mortality and thereby imposes high health costs on society. The prevalence of AF has increased for several decades, and is expected to increase further, with the rising numbers of elderly people and survivors of heart diseases. Several risk factors for AF related to genetics and diseases have been ... -
Atrial fibrillation is associated with cognitive decline in stroke-free subjects: the Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-28)Background and purpose:<br>Previous studies have shown associations between atrial fibrillation (AF) and cognitive decline. We investigated this association in a prospective population study, focusing on whether stroke risk factors modulated this association in stroke-free women and men.<br>Methods:<br>We included 4983 participants (57% women) from the fifth survey of the Tromsø Study (Tromsø 5, ... -
Atrial fibrillation, venous thromboembolism, ischemic stroke, and all-cause mortality: The Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-06)Background Atrial fibrillation (AF) is associated with increased risk of ischemic stroke and all‐cause mortality. Patients with AF are also at increased risk of venous thromboembolism (VTE), but information on how AF impacts VTE‐related mortality is scarce. Objectives - To investigate the impact of AF on all‐cause mortality in subjects with and without a thromboembolic event (VTE or ischemic ... -
Atrial Fibrillation: A prospective population study of risk factors and complications. The Tromsø Study
(Doctoral thesis; Doktorgradsavhandling, 2018-04-26)Background: Atrial Fibrillation (AF) is the most common arrhythmia associated with increased mortality and morbidity. It increases the lifetime risk of stroke and heart failure and affects one’s quality of life and cognition. Objective: To investigate diastolic dysfunction as risk factor for AF and AF as a risk factor for stroke and cognitive decline. Methods: Participants from the Tromsø Study ... -
Attachment problems and mental health issues among long-term unemployed youth who had dropped out of high school
(Doctoral thesis; Doktorgradsavhandling, 2018-10-01)<i>Objectives</i>: We wanted to explore how unemployed youth, between 18 and 25 years of age, who had dropped out of school and were registered at the Norwegian Labour and Welfare Administration (NLWA), would describe and explain critical aspects of their school dropout processes (Study 1). Second, we wanted to investigate critically present knowledge on the role of parent-child attachment in school ... -
Attacking styles for Tromsø IL- A study of goals and how Tromsø IL score goals. -An investigation for classifying goal scoring patterns and scoring efficiency. A case study of Tromsø Idrettslag.
(Master thesis; Mastergradsoppgave, 2021-05-14)Abstract Attacking styles within Tromsø IL- A study of scored goals and how Tromsø IL score goals. The purpose of this study is finding what attacking styles and formation were most effective regarding scoring goals for Tromsø IL (TIL) in the competitive seasons 2018, 2019 and 2020. In total TIL have scored 140 goals over the three seasons which averages 46,6 goals per season. Analyses of which ... -
Attendance to cervical cancer screening among Roma and non-Roma women living in North-Western region of Romania
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-27)<p><i>Objectives</i>: Romania has Europe’s highest incidence and mortality rates of cervical cancer. Participation in the national cervical cancer-screening programme is low, especially among minority Roma women.</p> <p><i>Methods</i>: We conducted a cross-sectional study, using a structured questionnaire aiming to quantify reasons for screening attendance among women in North-Western region of ... -
Attention-deficit/hyperactivity disorder symptoms, perceived stress, and suicidal ideation during the COVID-19 pandemic
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-09)Objective: Attention–deficit/hyperactivity disorder (ADHD) symptoms have been linked to suicidal behavior. However, little is known about the mechanisms involved in this association. This study examined ADHD symptoms and suicidal ideation during the COVID-19 pandemic and the role of self–perceived stress in this association.<p> <p>Method: Data were analyzed from an online sample of 1,452 Japanese ... -
Attenuated Notch signaling in schizophrenia and bipolar disorder
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-23)The Notch signaling pathway plays a crucial role in neurodevelopment and in adult brain homeostasis. We aimed to further investigate Notch pathway activity in bipolar disorder (BD) and schizophrenia (SCZ) by conducting a pathway analysis. We measured plasma levels of Notch ligands (DLL1 and DLK1) using enzyme immunoassays in a large sample of patients (SCZ n = 551, BD n = 246) and healthy controls ...
