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    • Systematic reporting to improve the emergency medical response to major incidents: A pilot study 

      Hardy, Sophie; Fattah, Sabina; Wisborg, Torben; Raatiniemi, Lasse; Staff, Trine; Rehn, Marius (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-24)
      <i>Background:</i> Major incidents affect us globally, and are occurring with increasing frequency. There is still no evidence-based standard regarding the best medical emergency response to major incidents. Currently, reports on major incidents are non-standardised and variable in quality. This pilot study examines the first systematic reports from a consensus-based, freely accessible database, ...

    • Systematic review and meta-analysis of Chinese herbal formula Tongxie Yaofang for diarrhea-predominant irritable bowel syndrome: Evidence for clinical practice and future trials 

      Liang, Shi-Bing; Cao, Hui-Juan; Kong, Ling-Yao; Wei, Jia-Li; Robinson, Nicola; Yang, Si-Hong; Zhu, Si-Jia; Li, Yu-Qi; Fei, Yu-Tong; Han, Mei; Liu, Jianping (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-25)
      Introduction: Diarrhea-predominant irritable bowel syndrome (IBS-D) significantly decreases the quality of life of patients and their families, and affects patients’ mental health. No specific western medications are available. Ancient classical Chinese medical texts have recognized Tongxie Yaofang (TXYF) as a therapy for diarrhea which is widely used in clinical practice. Standard TXYF prescription ...

    • A Systematic Review and Meta-Analysis of Measurement Feedback Systems in Treatment for Common Mental Health Disorders 

      Rognstad, Kristian; Wentzel-Larsen, Tore; Neumer, Simon-Peter; Kjøbli, John (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-25)
      To investigate the efects of measurement feedback systems (MFSs) in therapy on mental health outcomes through a literature review and meta-analysis. Using a three-level modeling approach, we conducted a meta-analysis of all efect sizes from randomized controlled studies of MFSs used in the treatment of common mental health disorders. Eighty-two efect sizes were extracted from the thirty-one included ...

    • A systematic review of association between organic environmental pollutants and testicular cancer 

      Vibe, Sofie Jonassen (Master thesis; Mastergradsoppgave, 2020-09-01)
      <p><i>Objective</i> There is an increasing incidence of testicular cancer in the world, which cannot be explained by factors as increasing life expectancy as this type of cancer typically affects young men. Particularly in certain countries that also score high on the Human Development Index (HDI) the incidence of testicular cancer is high, and as countries increase the HDI so does the incidence of ...

    • A systematic review of biomarkers among hospitalized patients with COVID-19 predictive of venous thromboembolism: A communication from the Predictive and Diagnostic Variables Scientific and Standardization Committee of the ISTH 

      Woller, Scott C.; de Wit, Kerstin; Robert-Ebadi, Helia; Masias, Camila; Klok, Frederikus A.; den Exter, Paul L.; Morange, Pierre-Emmanuel; Castelli, David; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-26)
      <p><b> Background</b> Thrombosis is reported to occur more often among patients with COVID-19 than otherwise expected in the setting of viral pneumonia and sepsis. Systemic inflammatory biomarkers may be associated with venous thromboembolism (VTE) risk. The ISTH subcommittee on Predictive and Diagnostic Variables in Thrombotic Disease aimed to report the evidence on prognostic biomarkers for VTE ...

    • Systematic review of clinical and patient-reported outcomes following oral rehabilitation on dental implants with a tapered compared to a non-tapered implant design 

      Jokstad, Asbjørn; Ganeles, Jeffrey (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-17)
      <p><i>Background</i>: Dental implants are available in different shapes.</p> <p><i>Aims</i>: This systematic review aims to address whether tapered compared to non‐tapered implants demonstrate similar clinical and patient‐reported outcomes. The review follows the preferred reporting items for systematic reviews and meta‐analyses (PRISMA) format.</p> <p><i>Materials & Methods</i>: We searched ...

    • A systematic review of quality of life research in medicine and health sciences 

      Haraldstad, Kristin; Wahl, Astrid Klopstad; Andenæs, Randi; Andersen, John Roger; Andersen, Marit Helen; Beisland, Elisabeth Grov; Borge, Christine Råheim; Engebretsen, Eivind; Eisemann, Martin; Halvorsrud, Liv Torill; Hanssen, Tove Aminda; Haugstvedt, Anne; Haugland, Trude; Johansen, Venke A; Larsen, Marie Hamilton; Løvereide, Lise; Løyland, Borghild; Kvarme, Lisbeth Gravdal; Moons, P; Norekvål, Tone M.; Ribu, Lis; Rohde, Gudrun E.; Urstad, Kristin Hjorthaug; Helseth, Sølvi (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-11)
      <i>Purpose</i>: Quality of life (QOL) is an important concept in the feld of health and medicine. QOL is a complex concept that is interpreted and defned diferently within and between disciplines, including the felds of health and medicine. The aims of this study were to systematically review the literature on QOL in medicine and health research and to describe the country of origin, target groups, ...

    • A systematic review of sex differences in the placebo and the nocebo effect 

      Vambheim, Sara Magelssen; Flaten, Magne (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-31)
      Objectives: The present review investigated whether there are systematic sex differences in the placebo and the nocebo effect. <br>Methods: A literature search was conducted in multiple electronic databases. Studies were included if the study compared a group or condition where a placebo was administered to a natural history group or similar cohort. <br>Results: Eighteen studies were identified ...

    • A systematic synthesis of qualitative studies on parents’ experiences of participating in early intervention programs with their infant born preterm 

      Øberg, Gunn Kristin; Sørvoll, Marit; Labori, Cathrine; Girolami, Gay L; Håkstad, Ragnhild B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-13)
      Early intervention programs involving both the parent and the infant born preterm have demonstrated positive effects on developmental outcomes for the children. However, studies have also shown that parental engagement and adherence when implementing intervention programs can be challenging. The aim of this review was to provide a comprehensive description and new insights into key messages gleaned ...

    • Systematisk oversikt over sykestueforskning med vekt på kvalitet, økonomi og pasientforløp 

      Nilsen, Karoline Damsgård (Master thesis; Mastergradsoppgave, 2017-09-17)
      Introduksjon: Samhandlingsreformen og den nye helse- og omsorgstjenesteloven påla alle kommuner å opprette øyeblikkelig hjelp døgntilbud fra 1.1.2016. Intermediærenheter som sykestuer har de siste tiårene fått økende fokus både i Norge og i utlandet. Målet med denne oppgaven er å lage en systematisk oversikt over forskningslitteratur som omhandler sykestuer med vekt på kvalitet, økonomi og ...

    • Systematiske oversikter og epidemiologisk forskning 

      Norderhaug, Inger Natvig (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      En god helsetjeneste forutsetter god kunnskap som grunnlag for de valg som gjøres. Systematiske oversikter som sammenfatter tilgjengelig forskningsbasert kunnskap er en viktig del av beslutningsgrunnlaget, enten det er snakk om effektene av tiltak, hvorfor sykdom oppstår, diagnostikk, prognose, eller hvordan sykdom oppleves for dem som rammes. Systematiske oversikter er blitt en vel anerkjent ...

    • Systemic family therapy for severe functional disorders in youths. A qualitative study in a psychiatric setting 

      Hulgaard, Ditte R; Risør, Mette Bech; Delholm, Gitte; Rask, Charlotte Ulrikke (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-15)
      This study aimed to explore participant experiences of systemic family therapy for youths with functional disorders. After completing family therapy, eight youths and thirteen parents participated in qualitative interviews. The analysis was based on interpretative phenomenological analysis and identified two main themes. The first theme was: ‘Challenges of creating meaning and understanding of child ...

    • Systemic inflammation markers and cancer incidence in the UK Biobank 

      Nøst, Therese Haugdahl; Alcala, Karine; Urbarova, Ilona; Byrne, Karl Smith; Guida, Florence; Sandanger, Torkjel M; Johansson, Mattias (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-25)
      Systemic inflammation markers have been linked to increased cancer risk and mortality in a number of studies. However, few studies have estimated pre-diagnostic associations of systemic inflammation markers and cancer risk. Such markers could serve as biomarkers of cancer risk and aid in earlier identification of the disease. This study estimated associations between pre-diagnostic systemic inflammation ...

    • Systemic lupus erythematosus: Definitions, contexts, conflicts, enigmas 

      Rekvig, Ole Petter (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-01)
      Systemic lupus erythematosus (SLE) is an inadequately defined syndrome. Etiology and pathogenesis remain largely unknown. SLE is on the other hand a seminal syndrome that has challenged immunologists, biologists, genetics, and clinicians to solve its nature. The syndrome is characterized by multiple, etiologically unlinked manifestations. Unexpectedly, they seem to occur in different stochastically ...

    • Systemisk lupus erytematosus : økte serumnivå av cytokinene APRIL, TRAIL og BAFF hos SLE-pasienter i Nord-Norge. 

      Gundersen, Ingunn Margareetta; Helland, Iren Eide (Master thesis; Mastergradsoppgave, 2012-06-01)
      Bakgrunn: Systemisk lupus erytematosus (SLE) er en autoimmun multiorgansykdom med komplisert og ikke fullstendig kartlagt patogenese. Pasientene har mange ulike symptomer, som gjør sykdommen vanskelig å diagnostisere både i primær- og spesialisthelsetjenesten. Cytokiner har en avgjørende rolle i dysregulering av celler og en viktig faktor ved lokal organskade. Tidligere studier har vist høye ...

    • Systems Epidemiology Approach in Endometrial Cancer. The NOWAC Study 

      Gavrilyuk, Oxana (Doctoral thesis; Doktorgradsavhandling, 2018-12-12)
      Endometrial cancer (EC) is one of the most common gynecologic cancers with extensively rising incidence worldwide. Norway is among the countries with the highest rates of EC. Although, most of the established risk factors for EC are well described, there are few studies from Norway investigating them in a cohort design. Moreover, modern clinical medicine, especially oncology, is moving towards ...

    • A Systems Epidemiology Approach to Breast Cancer and Parity. The Norwegian Women and Cancer (NOWAC) Study 

      Krum-Hansen, Sanda (Doctoral thesis; Doktorgradsavhandling, 2024-04-04)
      The incidence and prevalence of breast cancer (BC) are increasing worldwide. The reasons for this trend are partly unknown. BC has several well documented modifiable and non-modifiable risk factors. The only known, natural protective factors are breastfeeding and parity. The current paradigm is that the protective effect of parity is mediated by permanent genomic changes in a woman’s breast tissue ...

    • A Systems-Based Map of Human Brain Cell-Type Enriched Genes and Malignancy-Associated Endothelial Changes 

      Dusart, Philip James; Hallström, Björn M.; Renne, Thomas; Odeberg, Jacob Olof; Uhlén, Mathias; Butler, Lynn (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-05)
      Changes in the endothelium of the cerebral vasculature can contribute to inflammatory, thrombotic, and malignant disorders. The importance of defining cell-type-specific genes and their modification in disease is increasingly recognized. Here, we develop a bioinformatics-based approach to identify normal brain cell-enriched genes, using bulk RNA sequencing (RNA-seq) data from 238 normal human cortex ...

    • Særegne opplevelser forbundet med mindfulnessmeditasjon: En interpretativ fenomenologisk analyse 

      Schei, Andreas Hillestad (Master thesis; Mastergradsoppgave, 2016-07-30)
      Bakgrunnen for denne studien er fortellinger om sterke særegne opplevelser i forbindelse med meditasjon. På bakgrunn av økende utbredelse og popularitet av mindfulnesspraksiser i nyere tid syntes det viktig å undersøke erfaringer med sterke psykologiske opplevelser blant personer som praktiserer mindfulnessmeditasjon. Det ble gjennomført syv semistrukturerte intervjuer med fem kvinner og to menn ...

    • 'Søkelys på samfunnsmedisinen' : evaluering av kommunal samfunnsmedisinsk legetjeneste, offentlig legearbeid og de forebyggende oppgaver i fastlegeordningen 

      Pettersen, Betty; Johnsen, Roar (Research report; Forskningsrapport, 2005)
      Universitetet i Tromsø ved Institutt for Samfunnsmedisin har gjennom tre spørreskjemabaserte tverrsnittsundersøkelser studert kommunal samfunnsmedisinsk legetjeneste i forhold til arbeidsinnhold og arbeidsforhold før og etter Fastlegereformen, og hvilke faktorer som har påvirket utviklingen. Prosjektet inkluderer også intervjuer før og etter introduksjonen av reformen av kommunale administratorer, ...