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Symptomer og behandling av pasienter med akutt hjerteinfarkt innlagt ved Nordlandssykehuset i Bodø i 2017. Er det forskjeller mellom kvinner og menn?
(Master thesis; Mastergradsoppgave, 2019-05-21)<p>Innledning: Generelt har man sett en nedgang i dødelighet ved hjerte- og karsykdommer de siste tiårene, men fortsatt er sykdomsgruppen en av de hyppigste dødsårsakene her i landet. Forskning de siste årene har funnet diskrepans mellom kjønn når det gjelder symptomer, klinikk, diagnostikk og behandling, likevel er ikke retningslinjene for hjerteinfarkt endret siden 2004. Vi ønsket derfor å studere ... -
Symptomer på spiseforstyrrelser og fornøydhet med egen kropp
(Chapter; Bokkapittel, 2022-03-16)I dagens samfunn er overvekt og fedme hyppig forekommende og har derfor blitt mer akseptert i store deler av befolkningen. Samtidig fokuseres det i media på at idealet er å være slank, sunn og i god fysisk form. I to studier av deltakere i SAMINOR 2 – den kliniske undersøkelsen (2012–2014), var vi interessert i å studere symptomer på spiseforstyrrelser (Studie 1) og om underestimering av overvekt ... -
Symptomer, diagnostikk og behandling av akutt hjerteinfarkt med fokus på kjønnsforskjeller
(Master thesis; Mastergradsoppgave, 2015-05-27)Kardiovaskulære sykdommer er fortsatt den viktigste årsaken til morbiditet og mortalitet hos både menn og kvinner verden over. I Norge er iskemisk hjertesykdom en av de vanligste årsakene til død hos begge kjønn. Bare i 2013 ble det registrert 13043 hjerteinfarkt i Norge. Koronar hjertesykdom har tradisjonelt blitt sett på som en sykdom som hovedsakelig affiserer menn. Kvinner har derimot større ... -
Symptomer, diagnostisering og behandling av 184 tilfeller med medfødte isolerte, acyanotiske hjertefeil. En retrospektiv kvalitetsstudie av data for perioden 1999-2008 ved Nordlandssykehuset
(Master thesis; Mastergradsoppgave, 2020-08-31)Sammendrag Bakgrunn: Hensikten med studien er å skaffe en oversikt over symptomer, diagnostisering, behandling og prognose ved tre ulike typer acyanotiske hjertefeil ved Nordlandssykehuset. Pasientgrunnlaget er barn født med isolerte acyanotiske hjertefeil i perioden 1999-2008. Materialer og metode: Retrospektiv, deskriptiv studie basert på kvantitative data hentet ut fra pasientjournaler ved ... -
Symptoms and signs of colorectal cancer, with differences between proximal and distal colon cancer: a prospective cohort study of diagnostic accuracy in primary care
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-08)<i>Background</i> - In an abdominal symptom study in primary care in six European countries, 511 cases of cancer were recorded prospectively among 61,802 patients 16 years and older in Norway, Denmark, Sweden, Netherlands, Belgium and Scotland. Colorectal cancer is one of the main types of cancer associated with abdominal symptoms; hence, an in-depth subgroup analysis of the 94 colorectal cancers ... -
Symptoms and signs of urogenital cancer in primary care
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-26)Background - Urogenital cancers are common, accounting for approximately 20% of cancer incidence globally. Cancers belonging to the same organ system often present with similar symptoms, making initial management challenging. In this study, 511 cases of cancer were recorded after the date of consultation among 61,802 randomly selected patients presenting in primary care in six European countries: a ... -
Symptoms of Anxiety, Depression, and Post-Traumatic Stress Disorder in Health Care Personnel in Norwegian ICUs during the First Wave of the COVID-19 Pandemic, a Prospective, Observational Cross-Sectional Study.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-08)Background: The COVID-19 pandemic has induced demanding work situations in intensive care units (ICU). The objective of our study was to survey psychological reactions, the disturbance of social life, work effort, and support in ICU nurses, physicians, and leaders. Methods: From May to July 2020, this cross-sectional study included 484 ICU professionals from 27 hospitals throughout Norway. Symptoms ... -
Symptoms of Depression, Anxiety, and Posttraumatic Stress among Patients with Cardiac Pacemakers
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-15)Despite being a prerequisite for tailoring specific therapeutic interventions, knowledge of pattern and prevalence of clinically significant psychiatric symptomatology among patients with cardiac pacemakers (PMs), especially of symptoms of posttraumatic stress, is limited. We studied symptoms of depression, anxiety, and posttraumatic stress among PM patients (PM due to syncope or presyncope) ... -
Symptoms of respiratory tract infection and associated care-seeking in subjects with and without obstructive lung disease; The Tromso Study: Tromso 6.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Respiratory tract infections (RTIs) may be more severe in those with asthma or COPD and these patients are more frequently in need of health care. The aim of the study was to describe the frequency of RTI symptoms in a general adult population and how care-seeking is associated with the presence of obstructive lung disease. Cross-sectional data including spirometry and self-reported chronic diseases ... -
Symptoms Reported by Head and Neck Cancer Patients during Radiotherapy and Association with Mucosal Ulceration Site and Size: An Observational Study.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-10)<p>Background Self-reported pain and impairment of oral functions varies markedly and often in spite of extensive oral mucositis (OM). The aim of the current study was to appraise how patientreported debilitation caused by OM is influenced by the extent and possibly location of the OM lesions.<p>Methods Patients with head and neck cancer undergoing radiotherapy were examined before treatment, twice ... -
Symptoms, signs, and tests: The general practitioner's comprehensive approach towards a cancer diagnosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-09-16)Objective. To study the relative importance of different tools a GP can use during the diagnostic process towards cancer detection. <p>Design. Retrospective cohort study with prospective registration of cancer in general practice. Setting and subjects. One hundred and fi fty-seven Norwegian general practitioners (GPs) reported 261 cancer patients.<p> Method. During 10 consecutive days, GPs ... -
Synergistic effects of Radiotherapy and Immune Checkpoint Inhibitors in Cancer Treatment
(Master thesis; Mastergradsoppgave, 2016-05-31)Background: Use of immune checkpoint inhibitors have improved survival in patients suffering from cancer types such as advanced melanoma and NSCLC. Through increased understanding of immunological reactions associated with radiotherapy, a potential for synergy of radiotherapy and immune checkpoint inhibitors has emerged. Preclinical proof-of-concept studies have confirmed synergy of the treatments ... -
Synkope som utskrivelsesdiagnose - forekomst, utredning, diagnose og behandling
(Master thesis; Mastergradsoppgave, 2019-06-03)Bakgrunn: Synkope er definert som et forbigående tap av bevissthet, som følge av global cerebral hypoperfusjon, og karakterisert av rask start, kort varighet og spontan full tilfriskning. Synkope er et symptom som pasienten presenterer, men er ikke i seg selv en diagnose. Formålet med denne oppgaven er å kartlegge de vanligste årsakene til synkope som utskrivelsesdiagnose, hvilken utredning, behandling ... -
Synliggjøring av "De usynlige barna". Barn som pårørende av foreldre med psykiske lidelser og ruslidelser i behandling ved Psykisk helse- og rusklinikken, Universitetssykehuset i Nord-Norge
(Master thesis; Mastergradsoppgave, 2017-05-01)Bakgrunn: Kunnskapsstatus viser at det er en transgenerasjonell overføring av risiko og psykisk morbiditet fra foreldre til barn som pårørende (BAP), men det finnes relativt få implementerte tiltak tilpasset BAP i psykisk helsevern for voksne. Svake kartleggingsrutiner har bidratt til at vi fortsatt ikke vet hva som kjennetegner disse barna, deres livssituasjon, foreldrenes lidelser eller hvorvidt ... -
Synthesis and biological evaluation of a novel 18F-labeled radiotracer for PET imaging of the adenosine A2A receptor
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-25)The adenosine A<sub>2A</sub> receptor (A<sub>2A</sub>R) has emerged as a potential non-dopaminergic target for the treatment of Parkinson’s disease and, thus, the non-invasive imaging with positron emission tomography (PET) is of utmost importance to monitor the receptor expression and occupancy during an A<sub>2A</sub>R-tailored therapy. Aiming at the development of a PET radiotracer, we herein ... -
Synthesis and structural studies of cyclic bioactive cysteine rich peptides
(Mastergradsoppgave; Master thesis, 2009-05-20)Naturally occurring cyclic peptides have great therapeutic potential. Cyclotides are circular proteins found in the plants of the Rubiaceae, Violaceae and Cucurbitaceae families. They have an exceptional stability against chemical, enzymatic and thermal conditions due to their cyclic cystine knot (CCK) motif, which is the combination of a cyclic backbone and multiple disulfide bonds. In this thesis, ... -
Synthesis and structure-activity relationship studies of marine-derived antimicrobial peptides and small cyclic peptidomimetics
(Doctoral thesis; Doktorgradsavhandling, 2023-06-26)Effective antimicrobial drugs are the very core of modern medicine enabling successful prevention and treatment of infectious diseases. However, systemic misuse and overuse of antibiotics in human medicine, as well as in animal husbandry have led to widespread antibiotic-resistance, rendering many of these drugs ineffective. Therefore, there is an urgent need for new treatment options to conventional ... -
Synthesis of a novel tripeptidomimetic scaffold and biological evaluation for CXC chemokine receptor 4 (CXCR4) antagonism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-17)We here report the preparation of a new 2,6,8-trisubstituted bicyclic tripeptidomimetic scaffold through TFA-mediated cyclization of a linear precursor containing three side chains. The introduction of a triphenylmethyl-protected thiol into carboxylic acid containing building blocks through sulfa Michael additions onto α,β-unsaturated hexafluoroisopropyl esters is described. The stereoselectivity ... -
Synthesis of copper and silver nanoparticles with extracts of berries: A green chemistry approach
(Master thesis; Mastergradsoppgave, 2017-05-15)Nanoparticles are usually defined as particles in a size range of 1-100 nm, and these particles often have different properties than the non-nanoscale material of the same chemical composition. In recent years, as the interest and use of nanoparticles has increased and so has the interest in understanding their behaviour, impact and fate in the environment. In the last decades, there has been special ... -
Synthesis, bioactivity testing, and structure elucidation of antimicrobial peptide analogues derived from Synoicum Turgens
(Mastergradsoppgave; Master thesis, 2023-05-15)A method was developed for synthesizing and isolating two DRPs, with varying levels of success affected by difficulties in the purification process and human error. However, it has shed light on some of the difficulties that may occur and suggestions on how they could be improved. The method developed structure elucidation through sequential reduction and alkylation of the disulfide bridges proved ...
