Browsing Mastergradsoppgaver i marin bioteknologi by Author "Thim, Hanna Leena"
-
SAV Ag CpG/polyI:C formulated vaccination potentiate protective immune responses in Atlantic salmon - no additive or synergistic effect present when co-injecting a Rhabdovirus G-DNA vaccine
Thim, Hanna Leena (Master thesis; Mastergradsoppgave, 2013-02-11)Vaccines of today rely on adjuvant efficacy to provide a link between innate and adaptive immunity. CpG oligodeoxynucleotides (ODN) and polyinosinic:polycytidylic acid (polyI:C) are both toll-like receptor (TLR) ligands signaling through a combination of pathogen recognition receptors (PRR) and in mammals CpG/polyI:C are known to induce T-helper 1 (Th1) and cytotoxic T-lymphocyte (CTL) responses. ...